Comparison of the properties of turmeric starch-dioscin-curcumin nanocarriers prepared by antisolvent co-precipitation and antisolvent precipitation

Zhu, Wenqing; Bai, Xinyan; Du, Wenbo; Li, Lingyu; Fauconnier, Marie-Laure; Richel, Aurore; Dong, Hongjing; Zheng, Zhenjia

doi:10.1016/j.carbpol.2025.123263

Article (Scientific journals)

Comparison of the properties of turmeric starch-dioscin-curcumin nanocarriers prepared by antisolvent co-precipitation and antisolvent precipitation

Zhu, Wenqing; Bai, Xinyan; Du, Wenbo et al.

2025 • In Carbohydrate Polymers, p. 123263

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/328340

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10.1016/j.carbpol.2025.123263

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Keywords :

Curcumin; Antisolvent; co-precipitation; in vitro relase

Abstract :

[en] In this study, two modified turmeric starch-dioscin-curcumin nanocarriers were synthesized by antisolvent co-precipitation (ASCP) and antisolvent precipitation (ASP) methods, with dioscin serving as a natural surfactant. Subsequently, the structural characteristics, physical stability, and curcumin sustained release properties of nanocarriers were comprehensively characterized. The results indicated that both modified nanocarriers exhibited similar morphology and functional groups, along with enhanced physical stability and storage stability. Both ASCP and ASP methods reduced the particle size of nanocarriers while enhancing encapsulation efficiency and loading capacity. Notably, the nanocarrier prepared using the ASCP method exhibited the smallest particle size (260.50 ± 9.01 nm), the highest encapsulation efficiency (59.06 ± 1.73 %), and the greatest loading capacity (7.18 ± 0.21 μg/mg). Additionally, the release rate and bioavailability of ASCP-TS-CUR were approximately 23 and 20 times higher than free curcumin, respectively. These findings support the potential of dioscin-modified starch nanocarriers for the effective delivery of hydrophobic compounds, and the ASCP method was proved to have better modification effects, providing a novel green strategy for the construction of delivery systems.

Disciplines :

Chemistry
Food science

Author, co-author :

Zhu, Wenqing ; Université de Liège - ULiège > TERRA Research Centre

Bai, Xinyan ; Université de Liège - ULiège > TERRA Research Centre

Du, Wenbo

Li, Lingyu

Fauconnier, Marie-Laure ; Université de Liège - ULiège > TERRA Research Centre > Chemistry for Sustainable Food and Environmental Systems (CSFES)

Richel, Aurore ; Université de Liège - ULiège > Département GxABT > Chemistry for Sustainable Food and Environmental Systems (CSFES)

Dong, Hongjing

Zheng, Zhenjia

Language :

English

Title :

Comparison of the properties of turmeric starch-dioscin-curcumin nanocarriers prepared by antisolvent co-precipitation and antisolvent precipitation

Publication date :

January 2025

Journal title :

Carbohydrate Polymers

ISSN :

0144-8617

eISSN :

1879-1344

Publisher :

Elsevier

Pages :

123263

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:S014486172500044X?httpAccept=text/xml

Available on ORBi :

since 14 February 2025

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