Contamination levels and distribution of persistent and non-persistent pollutants in paired hair, urine and serum samples from a Belgian non-occupationally exposed population.

Claessens, Julien; Dufour, Patrice; Dardenne, Nadia; Charlier, Corinne; Pirard, Catherine

doi:10.1080/15287394.2025.2451676

Article (Scientific journals)

Contamination levels and distribution of persistent and non-persistent pollutants in paired hair, urine and serum samples from a Belgian non-occupationally exposed population.

Claessens, Julien; Dufour, Patrice; Dardenne, Nadia et al.

2025 • In Journal of Toxicology and Environmental Health. Part A, p. 1 - 16

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/326950

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10.1080/15287394.2025.2451676

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39815779

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Keywords :

Biomonitoring; contamination levels; hair; serum; urine; paired samples

Abstract :

[en] Designing ideal human biomonitoring studies involves the selection of reliable markers of exposure in adequate biological matrix. Besides conventional matrices such as blood or urine, hair has been increasingly investigated as a promising noninvasive alternative. However, understanding the pollutant distribution between differing biological compartments is essential for reliable interpretation of data collected. Therefore, the contamination levels and the distribution of some persistent (8 perfluoroalkyl substances - PFAS - and 6 polychlorobiphenyls - PCBs) and non-persistent pollutants (2 bisphenols and 3 parabens) were investigated in paired serum and hair samples, or paired spot urine and hair samples obtained from 30 Belgian non-occupationally exposed individuals. The levels measured were close to those reported in recent larger-scale studies. PFAS, PCB and bisphenol distributions largely differed depending upon the matrix and within the same chemical family depending upon the congener. The correlation and agreement between pollutant levels in differing matrices demonstrated that the information provided is comparable only for highly chlorinated PCBs and parabens, while the classification of exposure for bisphenols was substantially different according to the matrix. The selection of the human matrix thus remains complex and might markedly bias the results obtained, especially when assessing the health risk related to chemical exposure.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Claessens, Julien ; Université de Liège - ULiège > Unités de recherche interfacultaires > Centre Interdisciplinaire de Recherche sur le Médicament (CIRM)

Dufour, Patrice ; Centre Hospitalier Universitaire de Liège - CHU > > Service de toxicologie clinique, médicolégale, environnementale et en entreprise

Dardenne, Nadia ; Université de Liège - ULiège > Département des sciences de la santé publique

Charlier, Corinne ; Université de Liège - ULiège > Département de pharmacie > Chimie toxicologique

Pirard, Catherine ; Centre Hospitalier Universitaire de Liège - CHU > > Service de toxicologie clinique, médicolégale, environnementale et en entreprise

Language :

English

Title :

Contamination levels and distribution of persistent and non-persistent pollutants in paired hair, urine and serum samples from a Belgian non-occupationally exposed population.

Publication date :

16 January 2025

Journal title :

Journal of Toxicology and Environmental Health. Part A

ISSN :

1528-7394

eISSN :

1087-2620

Publisher :

Informa UK Limited, England

Pages :

1 - 16

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://www.tandfonline.com/doi/pdf/10.1080/15287394.2025.2451676

Available on ORBi :

since 17 January 2025

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