[en] OBJECTIVES: This study aimed to evaluate the potential clinical value of a new brain age prediction model as a single interpretable variable representing the condition of our brain. Among many clinical use cases, brain age could be a novel outcome measure to assess the preventive effect of life-style interventions.
METHODS: The REMEMBER study population (N = 742) consisted of cognitively healthy (HC,N = 91), subjective cognitive decline (SCD,N = 65), mild cognitive impairment (MCI,N = 319) and AD dementia (ADD,N = 267) subjects. Automated brain volumetry of global, cortical, and subcortical brain structures computed by the CE-labeled and FDA-cleared software icobrain dm (dementia) was retrospectively extracted from T1-weighted MRI sequences that were acquired during clinical routine at participating memory clinics from the Belgian Dementia Council. The volumetric features, along with sex, were combined into a weighted sum using a linear model, and were used to predict 'brain age' and 'brain predicted age difference' (BPAD = brain age-chronological age) for every subject.
RESULTS: MCI and ADD patients showed an increased brain age compared to their chronological age. Overall, brain age outperformed BPAD and chronological age in terms of classification accuracy across the AD spectrum. There was a weak-to-moderate correlation between total MMSE score and both brain age (r = -0.38,p < .001) and BPAD (r = -0.26,p < .001). Noticeable trends, but no significant correlations, were found between BPAD and incidence of conversion from MCI to ADD, nor between BPAD and conversion time from MCI to ADD. BPAD was increased in heavy alcohol drinkers compared to non-/sporadic (p = .014) and moderate (p = .040) drinkers.
CONCLUSIONS: Brain age and associated BPAD have the potential to serve as indicators for, and to evaluate the impact of lifestyle modifications or interventions on, brain health.
Disciplines :
Neurosciences & behavior
Author, co-author :
Wittens, Mandy M J; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium ; Department of Neurology, Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium ; Neuroprotection and Neuromodulation (NEUR) Research Group, Center for Neurosciences (C4N), Vrije, Universiteit Brussel (VUB), Brussels, Belgium
Denissen, Stijn; icometrix, Leuven, Belgium ; AIMS lab, Center for Neurosciences (C4N), Vrije Universiteit Brussel, UZ Brussel, Brussels, Belgium
Sima, Diana M; Neuroprotection and Neuromodulation (NEUR) Research Group, Center for Neurosciences (C4N), Vrije, Universiteit Brussel (VUB), Brussels, Belgium ; icometrix, Leuven, Belgium
Fransen, Erik; Centre of Medical Genetics, University of Antwerp, and Antwerp University Hospital - UZA, Edegem, Belgium
Niemantsverdriet, Ellis; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium
Benoit, Florence; Geriatrics Department, Brugmann University Hospital, Universite Libre de Bruxelles, Brussels, Belgium
Bergmans, Bruno; Neurology Department, AZ St-Jan Brugge, Brugge, Belgium ; Ghent University Hospital, Ghent, Belgium
Bier, Jean-Christophe; Neurological department H. U. B. - Erasme Hospital - Vrije Universiteit Brussel (VUB), Brussels, Belgium
de Deyn, Peter Paul; Laboratory of Neurochemistry and Behavior, Experimental Neurobiology Unit, University of Antwerp, Antwerp, 2610, Belgium ; Memory Clinic, Ziekenhuisnetwerk, Antwerp, Belgium
Deryck, Olivier; Neurology Department, AZ St-Jan Brugge, Brugge, Belgium ; Ghent University Hospital, Ghent, Belgium
Hanseeuw, Bernard; Institute of Neuroscience, Université Catholique de Louvain, Brussels, 1200, Belgium ; Department of Neurology, Clinique Universitaires Saint-Luc, Brussels, 1200, Belgium ; WELBIO Department, WEL Research Institute, Wavre, 1300, Belgium
Ivanoiu, Adrian; Department of Neurology, Cliniques Universitaires St Luc, and Institute of Neuroscience, Université Catholique de Louvain, Woluwe-Saint-Lambert (Brussels), Belgium
Picard, Gaëtane; Department of Neurology, Clinique Saint-Pierre, Ottignies, Belgium
Ribbens, Annemie; icometrix, Leuven, Belgium
Salmon, Eric ; Université de Liège - ULiège > Département des sciences cliniques
Segers, Kurt; Memory Clinic - Neurology and Geriatrics Department, CHU Brugmann, Van Gehuchtenplein 4, Brussels, 1020, Belgium
Sieben, Anne; Neuropathology Lab, IBB-NeuroBiobank BB190113, Born Bunge Institute, Antwerp, Belgium ; Department of Pathology, Antwerp University Hospital - UZA, Antwerp, Belgium ; Laboratory of Neurology, Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium
Struyfs, Hanne; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium ; Department of Neurology, Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium ; Johnson and Johnson Innovative Medicine, Beerse, Belgium
Thiery, Evert; Department of Neurology, University Hospital Ghent, Ghent University, Ghent, Belgium
Tournoy, Jos; Department of Chronic Diseases, Metabolism and Ageing, Geriatric Medicine and Memory Clinic, University Hospitals Leuven and KU Leuven, Louvain, Belgium
Versijpt, Jan; Department of Neurology, Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium ; Neuroprotection and Neuromodulation (NEUR) Research Group, Center for Neurosciences (C4N), Vrije, Universiteit Brussel (VUB), Brussels, Belgium
Smeets, Dirk; Neuroprotection and Neuromodulation (NEUR) Research Group, Center for Neurosciences (C4N), Vrije, Universiteit Brussel (VUB), Brussels, Belgium ; icometrix, Leuven, Belgium
Bjerke, Maria; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium ; Neuroprotection and Neuromodulation (NEUR) Research Group, Center for Neurosciences (C4N), Vrije, Universiteit Brussel (VUB), Brussels, Belgium ; Department of Clinical Chemistry, Laboratory of Neurochemistry, Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium
Nagels, Guy; Department of Neurology, Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium ; St. Edmund Hall, University of Oxford, Oxford, UK ; AIMS lab, Center for Neurosciences (C4N), Vrije Universiteit Brussel, UZ Brussel, Brussels, Belgium
Engelborghs, Sebastiaan; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium. sebastiaan.engelborghs@uzbrussel.be ; Department of Neurology, Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium. sebastiaan.engelborghs@uzbrussel.be ; Neuroprotection and Neuromodulation (NEUR) Research Group, Center for Neurosciences (C4N), Vrije, Universiteit Brussel (VUB), Brussels, Belgium. sebastiaan.engelborghs@uzbrussel.be
ERDF - European Regional Development Fund VLAIO - Flanders Innovation and Entrepreneurship FWO - Fonds Wetenschappelijk Onderzoek Vlaanderen
Funding text :
This research was in part supported by the agency of Flanders Innovation & Intrepreneurship (VLAIO), the Flemish Agency for Innovation by Science and Technology (IWT 140262), the Interreg V programme Flanders-The Netherlands of the European Regional Development Fund (ERDF) (Herinneringen/Memories project), the European Union\u2019s Horizon 2020 research and innovation programme under grant agreement numbers 666992 (EUROPOND) and 765148 (TRABIT). For the University of Li\u00E8ge center, this work was supported by a French Speaking Community Concerted Research Action (ARC-06/11\u2013340) and a Belgian InterUniversity Attraction Pole (P6/29). SD is funded by an industrial grant (Baekeland, HBC.2019.2579) from VLAIO. GN is a senior clinical research fellow of the Fonds Wetenschappelijk Onderzoek (FWO) Flanders (1805620N).
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