Article (Scientific journals)
Thermodynamics of Intragenic Nucleosome Ordering
Chevereau, Guillaume; Palmeira, Leonor; Thermes, Claude et al.
2009In Physical Review Letters, 103 (18), p. 118103
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Abstract :
[en] The nucleosome ordering observed in vivo along yeast genes is described by a thermodynamical model of nonuniform fluid of 1D hard rods confined by two excluding energy barriers at gene extremities. For interbarrier distances L≲1.5  kbp, nucleosomes equilibrate into a crystal-like configuration with a nucleosome repeat length (NRL) L/n∼165  bp, where n is the number of regularly positioned nucleosomes. We also observe “bistable” genes with a fuzzy chromatin resulting from a statistical mixing of two crystal states, one with an expanded chromatin (NRL ∼L/n) and the other with a compact one (NRL ∼L/(n+1)). By means of single nucleosome switching, bistable genes may drastically alter their expression level as suggested by their higher transcriptional plasticity. These results enlighten the role of the intragenic chromatin on gene expression regulation.
Disciplines :
Physical, chemical, mathematical & earth Sciences: Multidisciplinary, general & others
Author, co-author :
Chevereau, Guillaume
Palmeira, Leonor ;  Université de Liège - ULiège > Immunologie et vaccinologie
Thermes, Claude
Arneodo, Alain
Vaillant, Cédric
Language :
English
Title :
Thermodynamics of Intragenic Nucleosome Ordering
Publication date :
2009
Journal title :
Physical Review Letters
ISSN :
0031-9007
eISSN :
1079-7114
Publisher :
American Physical Society, Ridge, United States - New York
Volume :
103
Issue :
18
Pages :
118103
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 13 January 2010

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