Article (Scientific journals)
Whole body barometric plethysmography: a screening method to investigate airway reactivity and acute lung injuries in freely moving pigs
Halloy, D.; Kirschvink, Nathalie; Vincke, G. et al.
2004In Veterinary Journal, 168, p. 276-284
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Keywords :
Penh; breathing mechanics; cholinergic; bronchoconstriction; endotoxins
Abstract :
[en] The aim of this work was to investigate whether the Penh index, measured using whoie body barometric piethysmography, can be used as a screening parameter to evaluate the airway reactivity and the intensity of the pulmonary response to endotoxins. Penh was firstly recorded in non-sedated freeiy moving piglets exposed (1) to a nebulized acetylchoiine (Ach) pre-treated or not with cienbuterol, or (2) to endotoxin challenge. To measure Penh simultaneously with total pulmonary resistance (RL), dynamic compliance (cd1) and intrapleural pressure changes (MaxPpl), an oesophageal balloon catheter technique was used and the piglets were anaesthetised. The recordings were performed during (1) an intravenous metacholine (Mch) challenge and (2) in endotoxin-exposed animais. In freely moving animais, Ach induced a significant dose-dependent increase in Penh, which was significantly blocked by clenbuterol. Endotoxin instillation aiso resulted in a significant rise in Penh while the corresponding response measured under anaesthesia was signiflcantly and positively correlated with RL and MaxzPpi. Similar results were obtained during Mch challenge but the Penh was negatively correlated with Cd. We conclude that Penh could be used in freely moving piglets as a screening index for airway reactivity and pulmonary functional changes in cholinergic and endotoxin challenges
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Halloy, D.;  Université de Liège - ULiège
Kirschvink, Nathalie ;  Université de Liège - ULiège
Vincke, G.;  Université de Liège - ULiège
Hamoir, J.;  Université de Liège - ULiège
Delvaux, F.;  Université de Liège - ULiège
Gustin, Pascal ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Pharmacologie, pharmacothérapie et toxicologie
Language :
English
Title :
Whole body barometric plethysmography: a screening method to investigate airway reactivity and acute lung injuries in freely moving pigs
Publication date :
2004
Journal title :
Veterinary Journal
ISSN :
1090-0233
eISSN :
1532-2971
Publisher :
Elsevier
Volume :
168
Pages :
276-284
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture [BE]
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
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