Article (Scientific journals)
Gene activation therapy: from the BLV model to HAM/TSP patients.
Lezin, Agnes; Olindo, Stephane; Belrose, Gildas et al.
2009In Frontiers in Bioscience. Scholar Edition, 1, p. 205-15
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Keywords :
Animals; Gene Expression; Genetic Therapy; Humans; Leukemia Virus, Bovine/genetics/physiology; Models, Biological; Paraparesis, Tropical Spastic/genetics/therapy; Sheep
Abstract :
[en] HTLV-1 (human T-lymphotropic virus type 1) and BLV (bovine leukemia virus) are two related retroviruses infecting CD4+ and B lymphocytes in humans and ruminants, respectively. During infection, the host-pathogen interplay is characterized by very dynamic kinetics resulting in equilibrium between the virus, which attempts to proliferate, and the immune response, which seeks to exert tight control of the virus. A major determinant of disease induction by both viruses is the accumulation of provirus in peripheral blood. In the absence of viral proteins, virus infected cells escape recognition and destruction by the host immune response. We propose a novel therapeutic strategy based on transient activation of viral expression using epigenetic modulators; this exposes infected cells to the immune response and results in significant reductions in proviral loads. In the absence of satisfactory therapies, this viral gene-activation strategy might delay progression, or even be curative, for HTLV-1 induced myelopathy / tropical spastic paraparesis (HAM/TSP).
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Author, co-author :
Lezin, Agnes
Olindo, Stephane
Belrose, Gildas
Signate, Aissatou
Cesaire, Raymond
Smadja, Didier
Macallan, Derek
Asquith, Becca
Bangham, Charles
Bouzar, Amel ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech
Gillet, Nicolas ;  Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.
Defoiche, Julien
Florins, ARNAUD-FRANCOIS ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech
Verlaeten, Olivier
Burny, Arsène ;  Université de Liège - ULiège > Agro Biotech Gembloux
Willems, Luc  ;  Université de Liège - ULiège > GIGA-Research - Gembloux Agro-Bio Tech
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Title :
Gene activation therapy: from the BLV model to HAM/TSP patients.
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Journal title :
Frontiers in Bioscience. Scholar Edition
Publisher :
Frontiers in Bioscience, United States - New York
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Peer reviewed :
Peer Reviewed verified by ORBi
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since 15 December 2009


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