Generalized sarcoidosis associated with hypertrophic osteopathy in a Standardbred racehorse.

[en] A Standardbred racehorse was presented for exercise intolerance, weight loss, pyrexia and facial deformity. Radiography and ultrasonography revealed periostitis and regional soft tissue swelling of maxillary bones. Computed tomography excluded any dental or sinus origin of these abnormalities. Further deformities on distal limbs and skin lesions appeared during hospitalization. Radiography identified bilateral periostitis and soft tissue swelling in the distal radius and metatarsal bones, as observed in the head, suggestive of hypertrophic osteopathy (HO). Skin biopsies revealed granulomatous dermatitis, indicating equine sarcoidosis (ES). The horse was euthanized due to rapid deterioration of his condition. Post-mortem examination and histopathology revealed splenomegaly, several pulmonary nodules and disseminated granulomatous lesions. These findings confirmed the diagnosis of generalized ES, or equine idiopathic systemic granulomatous disease. The concurrent with HO was probably associated with the intrathoracic pathology. Polymerase chain reaction (PCR) on pooled tissues identified equine herpesvirus 5 (EHV-5) DNA.

Research Center/Unit :

FARAH - Fundamental and Applied Research for Animals and Health - ULiège

Disciplines :

Anatomy (cytology, histology, embryology...) & physiology
Veterinary medicine & animal health

Author, co-author :

Charles, Alexandre ; Université de Liège - ULiège > Département d'Enseignement et de Clinique des Equidés (DCE) > Imagerie médicale des équidés

Kerckhove, H Vande; Department of Clinical Sciences of Equids, Equine Division, Internal Medicine Section, Faculty of Veterinary Medicine University of Liège, Liège, Belgium

De Maré, Lorie ; Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH) > FARAH: Médecine vétérinaire comparée

Cassart, Dominique ; Université de Liège - ULiège > Département de morphologie et pathologie (DMP)

Ficheroulle, Jérémie ; Université de Liège - ULiège > Département d'Enseignement et de Clinique des animaux de Compagnie (DCC) > Imagerie médicale des animaux de compagnie

de la Rebière de Pouyade, Geoffroy ; Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH) > FARAH: Médecine vétérinaire comparée

Tosi, Irène ; Université de Liège - ULiège > Département des sciences fonctionnelles (DSF)

Language :

English

Title :

Generalized sarcoidosis associated with hypertrophic osteopathy in a Standardbred racehorse.

Publication date :

28 November 2024

Journal title :

Journal of Equine Veterinary Science

ISSN :

0737-0806

eISSN :

1542-7412

Publisher :

Elsevier BV, United States

Volume :

144

Pages :

105249

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:S0737080624002557?httpAccept=text/xml

Available on ORBi :

since 09 December 2024

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