Capparis spinosa: A rich source of phenolic compounds - A comprehensive review of its phytochemistry, health benefits, and biotechnological applications
capparis spinosa; secondary metabolites; in vitro culture
Abstract :
[en] Caper (Capparis spinosa) is a plant of significant socio-economic importance in the Mediterranean
region which is traditionally used to fight various metabolic diseases. It has indeed long been
recognized for its medicinal properties, notably attributed to its rich nutritional content and
potent antioxidant activity due to phenolic compounds and other secondary metabolites. However, the commercial production of relevant secondary metabolites requires innovative approaches improving the biosynthesis of these metabolites to fulfill the industrial demand and
mitigate the overexploitation of natural resources. For this end, different techniques such as cell
suspension culture, hairy roots culture, biotic and abiotic elicitors supply as well as genetic engineering could be used to enhance the production of caper-derived secondary metabolites. In
addition, omics tools including genomics, transcriptomics, metabolomics and proteomics can help
to elucidate the biosynthetic pathway and altering the production of targeted metabolites. While
this review first highlights the phytochemistry, ethno-pharmacological uses, and biological activities of caper, it also discusses the significance of in vitro culture systems, omics tools and
metabolic engineering approaches to improve the production of caper-derived bioactive
compounds.
Genva, Manon ; Université de Liège - ULiège > Département GxABT > Chemistry for Sustainable Food and Environmental Systems (CSFES)
Fakiri, Malika
El-Goumi, Younes
Zeroual, Abdelmonim
Fauconnier, Marie-Laure ; Université de Liège - ULiège > TERRA Research Centre > Chemistry for Sustainable Food and Environmental Systems (CSFES)
Language :
English
Title :
Capparis spinosa: A rich source of phenolic compounds - A comprehensive review of its phytochemistry, health benefits, and biotechnological applications
Abdelkawy, A.M., Alshammari, S.O., Hussein, H.-A.A., Abou El-Enain, I.M., Abdelkhalek, E.S., Radwan, A.M., Kenawy, S.K., Maaty, D.A., Abed, N.N., Sabry, S., Effect of silver nanoparticles on tropane alkaloid production of transgenic hairy root cultures of hyoscyamus muticus l. And their antimicrobial activity. Sci. Rep., 13, 2023, 10397.
Abdulhafiz, F., Mohammed, A., Reduan, M.F.H., Kari, Z.A., Wei, L.S., Goh, K.W., Plant cell culture technologies: a promising alternatives to produce high-value secondary metabolites. Arab. J. Chem., 15, 2022, 104161.
Aburjai, T., Hudaib, M., Tayyem, R., Yousef, M., Qishawi, M., Ethnopharmacological survey of medicinal herbs in Jordan, the Ajloun Heights region. J. Ethnopharmacol. 110 (2007), 294–304.
Abu-Shama, H.S., Effect of caper (Capparis spinosa) extracts as a natural antimicrobial agent. J. Food dairy. sci. 10 (2019), 209–216.
Acharjee, S., Kumar, R., Kumar, N., Role of plant biotechnology in enhancement of alkaloid production from cell culture system of Catharanthus roseus: a medicinal plant with potent anti-tumor properties. Ind. Crops Prod., 176, 2022, 114298.
Afzal, S., Afzal, N., Awan, M.R., Khan, T.S., Gilani, A., Khanum, R., Tariq, S., Ethno-botanical studies from Northern Pakistan. J. Ayub Med. Coll. Abbottabad 21 (2009), 52–57.
Ahmadi, M., Saeidi, H., Genetic diversity and structure of Capparis spinosa L. In Iran as revealed by ISSR markers. Physiol. Mol. Biol. Plants 24 (2018), 483–491.
Aichi-Yousfi, H., Meddeb, E., Rouissi, W., Hamrouni, L., Rouz, S., Rejeb, M.N., Ghrabi-Gammar, Z., Phenolic composition and antioxidant activity of aqueous and ethanolic leaf extracts of six Tunisian species of genus Capparis–Capparaceae. Ind. Crops Prod. 92 (2016), 218–226.
Akgül, A., Özcan, M., Some compositional characteristics of capers (Capparis spp,) seed and oil. Grasas Aceites 50 (1999), 49–52.
Aksay, O., Selli, S., Kelebek, H., LC-DAD-ESI-MS/MS-based assessment of the bioactive compounds in fresh and fermented caper (Capparis spinosa) buds and berries. Food Chem., 337, 2021, 127959.
Alamholo, M., Soltani, J., Agrobacterium rhizogenes-mediated transformation as a means for induction of hairy roots and secondary metabolites in thymus daenensis. Biol. Bull., 1–7, 2023.
Alcalde, M.A., Perez-Matas, E., Escrich, A., Cusido, R.M., Palazon, J., Bonfill, M., Biotic elicitors in adventitious and hairy root cultures: a review from 2010 to 2022. Molecules, 27, 2022, 5253.
Alipour, F., Nabigol, A., Nabizadeh, E., Variation in volatile organic compounds in fruits of Iranian Capparis spinosa L. Accessions. Saudi J. Biol. Sci. 28 (2021), 4664–4667.
Aliyazicioglu, R., Eyupoglu, O.E., Sahin, H., Yildiz, O., Baltas, N., Phenolic components, antioxidant activity, and mineral analysis of capparis spinosa L. Afr. J. Biotechnol. 12 (2013), 6643–6649.
Alkhaibari, A.M., Alanazi, A.D., Chemical composition and insecticidal, antiplasmodial, and anti-leishmanial activity of Capparis spinosa essential oil and its main constituents. Evid. Based Comple. Alternat. Med., 2022, 2022.
Allaith, A.A.A., Assessment of the antioxidant properties of the caper fruit (Capparis spinosa L.) from Bahrain. J. Assoc. Arab Univ. Basic Appl. Sci. 19 (2016), 1–7.
Al-Tamimi, A., Khatib, M., Pieraccini, G., Mulinacci, N., Quaternary ammonium compounds in roots and leaves of Capparis spinosa L. From Saudi Arabia and Italy: investigation by HPLC-MS and 1H NMR. Nat. Prod. Res. 33 (2019), 1322–1328.
Altundag, E., Ozturk, M., Ethnomedicinal studies on the plant resources of east Anatolia, Turkey. Procedia-Soc. Behav. Sci. 19 (2011), 756–777.
Alzahrani, D., Albokhari, E., Yaradua, S., Abba, A., The complete plastome sequence for the medicinal species Capparis spinosa L.(Capparaceae). Gene. Rep., 23, 2021, 101059.
Al-Zubaidy, A.A., Khalil, A.M., Gastroprotective effect of Capparis spinosa on indomethacin-induced gastric ulcer in rats. Arch. Razi. Inst. 77 (2022), 1437–1445.
Andrade, M., Ribeiro-Santos, R., Sanches, S.A., Exploring plant cells for the production of compounds of interest. Explor. Plant Cells Prod. Compd. Interest, 2021, 145–170.
Ara, K.M., Karami, M., Raofie, F., Application of response surface methodology for the optimization of supercritical carbon dioxide extraction and ultrasound-assisted extraction of Capparis spinosa seed oil. J. Supercrit. Fluids 85 (2014), 173–182.
Ascrizzi, R., Cioni, P.L., Giusti, G., Pistelli, L., Flamini, G., Patterns in volatile emission of different aerial parts of caper (Capparis spinosa L.). Chem. Biodivers. 13 (2016), 904–912.
Ashraf, U., Chaudhry, M.N., Ahmad, S.R., Ashraf, I., Arslan, M., Noor, H., Jabbar, M., Impacts of climate change on Capparis spinosa L. Based on ecological niche modeling. PeerJ, 6, 2018, e5792.
Assadi, S., Shafiee, S.M., Erfani, M., Akmali, M., Antioxidative and antidiabetic effects of Capparis spinosa fruit extract on high-fat diet and low-dose streptozotocin-induced type 2 diabetic rats. Biomed. Pharmacother., 138, 2021, 111391.
Bacchetti, T., Campagna, R., Sartini, D., Cecati, M., Morresi, C., Bellachioma, L., Martinelli, E., Rocchetti, G., Lucini, L., Ferretti, G., C. Spinosa l. Subsp. Rupestris phytochemical profile and effect on oxidative stress in normal and cancer cells. Molecules, 27, 2022, 6488.
Bagal, D., Chowdhary, A.A., Mehrotra, S., Mishra, S., Rathore, S., Srivastava, V., Metabolic engineering in hairy roots: an outlook on production of plant secondary metabolites. Plant Physiol. Biochem., 107847, 2023.
Banerjee, P., Maity, S., Das, T., Mazumder, S., A double-blind randomized placebo-controlled clinical study to evaluate the efficacy and safety of a polyherbal formulation in geriatric age group: a phase IV clinical report. J. Ethnopharmacol. 134 (2011), 429–433.
Bodaghzadeh, A., Alirezalu, K., Amini, S., Alirezalu, A., Domínguez, R., Lorenzo, J.M., Fatty acid composition, phytochemicals and antioxidant potential of Capparis spinosa sedes. Grasas Aceites, 72, 2021, e430 e430.
Bourhim, T., Chakhchar, A., Lamaoui, M., El Kharrassi, Y., Alaoui, A., El Modafar, C., Ibnou Ali El Alaoui, M., Hsissou, D., Morphological characterization and assessment of genetic diversity of natural Moroccan populations of Capparis spinosa. Acta Physiol. Plant. 43 (2021), 1–10.
Bousta, D., Boukhira, S., Aafi, A., Ghanmi, M., el Mansouri, L., Ethnopharmacological Study of anti-diabetic medicinal plants used in the Middle-Atlas region of Morocco (Sefrou region). Int. J. Pharma Res. Health Sci. 2 (2014), 75–79.
Bouzroud, S., El Maaiden, E., Sobeh, M., Merghoub, N., Boukcim, H., Kouisni, L., El Kharrassi, Y., Biotechnological approaches to producing natural antioxidants: anti-Ageing and skin longevity prospects. Int. J. Mol. Sci., 24, 2023, 1397.
Chandran, S., Raghu, A.V., Mohanan, K.V., In vitro conservation of rare, endangered, and threatened plants. Conservation and Sustainable Utilization of Bioresources, 2023, Springer, 391–408.
Changxing, L., Galani, S., Hassan, F., Rashid, Z., Naveed, M., Fang, D., Ashraf, A., Qi, W., Arif, A., Saeed, M., Biotechnological approaches to the production of plant-derived promising anticancer agents: an update and overview. Biomed. Pharmacother., 132, 2020, 110918.
Chedraoui, S., Abi-Rizk, A., El-Beyrouthy, M., Chalak, L., Ouaini, N., Rajjou, L., Capparis spinosa L. In a systematic review: a xerophilous species of multi values and promising potentialities for agrosystems under the threat of global warming. Front. Plant Sci., 8, 2017, 1845.
Chibani, F., Skouri-Gargouri, H., Salem, A.B., Ghorbel, A., Zoghlami, N., Using genetic structure data and phylogenetic criteria in attributing prioritization scores for conservation of spontaneous Capparis spinosa L. Populations from Tunisia. J. Nat. Conserv. 37 (2017), 96–105.
Cornara, L., La Rocca, A., Marsili, S., Mariotti, M.G., Traditional uses of plants in the Eastern Riviera (Liguria, Italy). J. Ethnopharmacol. 125 (2009), 16–30.
Darwish, R.M., Aburjai, T.A., Effect of ethnomedicinal plants used in folklore medicine in Jordan as antibiotic resistant inhibitors on Escherichia coli. BMC Compl. Alternative Med. 10 (2010), 1–8.
Decraene, L.R., Smets, E.F., Evidence for carpel multiplications in the Capparaceae. Belg. J. Bot., 1997, 59–67.
Di Lodovico, S., Bacchetti, T., D'Ercole, S., Covone, S., Petrini, M., Di Giulio, M., Di Fermo, P., Diban, F., Ferretti, G., Cellini, L., Complex chronic wound biofilms are inhibited in vitro by the natural extract of Capparis spinose. Front. Microbiol., 13, 2022, 832919.
Dias, M.I., Sousa, M.J., Alves, R.C., Ferreira, I.C., Exploring plant tissue culture to improve the production of phenolic compounds: a review. Ind. Crops Prod. 82 (2016), 9–22.
Duman, E., Özcan, M.M., Mineral contents of seed and seed oils of Capparis species growing wild in Turkey. Environ. Monit. Assess. 186 (2014), 239–245.
Duran, R.E., Issah, H., The impact of strigolactone GR24 on Capparis spinosa L. Callus production and phenolic compound content. Plant Cell Tissue Organ Cult. PCTOC 149 (2022), 197–204.
Eddouks, M., Hebi, M., Ajebli, M., Medicinal Plants and gyneco-obstetric disorders among women in the South East of Morocco. Curr. Womens Health Rev. 16 (2020), 2–17.
Eddouks, M., Maghrani, M., Lemhadri, A., Ouahidi, M.-L., Jouad, H., Ethnopharmacological survey of medicinal plants used for the treatment of diabetes mellitus, hypertension and cardiac diseases in the south-east region of Morocco (Tafilalet). J. Ethnopharmacol. 82 (2002), 97–103.
El Amri, N., Errachidi, F., Bour, A., Bouhaddaoui, S., Chabir, R., Morphological and nutritional properties of Moroccan Capparis spinosa seeds. Sci. World J., 8594820, 2019, 8, 10.1155/2019/8594820.
El Azhary, K., Tahiri Jouti, N., El Khachibi, M., Moutia, M., Tabyaoui, I., El Hou, A., Achtak, H., Nadifi, S., Habti, N., Badou, A., Anti-inflammatory potential of Capparis spinosa L. In vivo in mice through inhibition of cell infiltration and cytokine gene expression. BMC Compl. Alternative Med. 17 (2017), 1–12.
El-Guendouz, S., Al-Waili, N., Aazza, S., Elamine, Y., Zizi, S., Al-Waili, T., Al-Waili, A., Lyoussi, B., Antioxidant and diuretic activity of co-administration of Capparis spinosa honey and propolis in comparison to furosemide. Asian Pac. J. Tropical Med. 10 (2017), 974–980.
El-Hilaly, J., Hmammouchi, M., Lyoussi, B., Ethnobotanical studies and economic evaluation of medicinal plants in Taounate province (Northern Morocco). J. Ethnopharmacol. 86 (2003), 149–158.
Fan, X., Lin, X., Ruan, Q., Wang, J., Yang, Y., Sheng, M., Zhou, W., Kai, G., Hao, X., Research progress on the biosynthesis and metabolic engineering of the anti-cancer drug camptothecin in Camptotheca acuminate. Ind. Crops Prod., 186, 2022, 115270.
Fattahi, M., Rahimi, R., Optimization of extraction parameters of phenolic antioxidants from leaves of Capparis spinosa using response surface methodology. Food Anal. Methods 9 (2016), 2321–2334.
Fazili, M.A., Bashir, I., Ahmad, M., Yaqoob, U., Geelani, S.N., In vitro strategies for the enhancement of secondary metabolite production in plants: a review. Bull. Natl. Res. Cent. 46 (2022), 1–12.
Fici, S., A taxonomic revision of the genus Capparis (Capparaceae) in New Caledonia. N. Z. J. Bot. 55 (2017), 407–423.
Fici, S., A taxonomic revision of the Capparis spinosa group (Capparaceae) from Eastern Africa to Oceania. Phytotaxa 203 (2015), 24–36.
Fici, S., A taxonomic revision of the Capparis spinosa group (Capparaceae) from the Mediterranean to central Asia. Phytotaxa 174 (2014), 1–24.
Fici, S., Intraspecific variation and evolutionary trends in Capparis spinosa L.(Capparaceae). Plant Systemat. Evol. 228 (2001), 123–141.
Fici, S., Averyanov, L.V., Sy, D.T., An updated checklist of the genus Capparis L. (Capparaceae) in Vietnam, including a new species from Hon Tre Island. Plants, 11(23), 2022, 3402, 10.3390/plants11233402.
Fu, X.P., Wu, T., Abdurahim, M., Su, Z., Hou, X.L., Aisa, H.A., Wu, H., New spermidine alkaloids from Capparis spinosa roots. Phytochem. Lett. 1 (2008), 59–62.
Gabr, A.M., Mabrok, H.B., Sytar, O., Smetanska, I., Recent advances toward development of plant cell culture process for sustainable production of lignans and their health benefits. Explor. Plant Cells Prod. Compd. Interest, 2021, 249–289.
Gantait, S., Mukherjee, E., Hairy root culture technology: applications, constraints and prospect. Appl. Microbiol. Biotechnol. 105 (2021), 35–53.
Giuffrida, D., Salvo, F., Ziino, M., Toscano, G., Dugo, G., Initial investigation on some chemical constituents of capers (Capparis spinosa L.) from the island of Salina. Ital. J. Food Sci., 14, 2002.
Graikou, K., Damianakos, H., Ganos, C., Syklowska-Baranek, K., Jeziorek, M., Pietrosiuk, A., Roussakis, C., Chinou, I., Chemical profile and screening of bioactive metabolites of Rindera graeca (A. Dc.) Bois. & Heldr.(Boraginaceae) in vitro cultures. Plants, 10, 2021, 834.
Grimalt, M., Hernández, F., Legua, P., Almansa, M.S., Amorós, A., Physicochemical composition and antioxidant activity of three Spanish caper (Capparis spinosa L.) Fruit cultivars in three stages of development. Sci. Hortic. 240 (2018), 509–515.
Grimalt, M., Hernández, F., Legua, P., Amorós, A., Almansa, M.S., Antioxidant activity and the physicochemical composition of young caper shoots (Capparis spinosa L.) of different Spanish cultivars. Sci. Hortic., 293, 2022, 110646.
Grimalt, M., Sánchez-Rodríguez, L., Hernández, F., Legua, P., Carbonell-Barrachina, Á.A., Almansa, M.S., Amorós, A., Volatile profile in different aerial parts of two caper cultivars (Capparis spinosa L.). J. Food Qual. 2021 (2021), 1–9.
Gristina, A.S., Fici, S., Siragusa, M., Fontana, I., Garfì, G., Carimi, F., Hybridization in Capparis spinosa L.: molecular and morphological evidence from a Mediterranean island complex. Flora-Morphol. Distrib. Funct. Ecol. Plants 209 (2014), 733–741.
Gull, T., Sultana, B., Anwar, F., Nouman, W., Mehmood, T., Sher, M., Characterization of phenolics in different parts of selected Capparis species harvested in low and high rainfall season. J. Food Meas. Char. 12 (2018), 1539–1547.
Güzel, Y., Güzelşemme, M., Miski, M., Ethnobotany of medicinal plants used in Antakya: a multicultural district in Hatay Province of Turkey. J. Ethnopharmacol. 174 (2015), 118–152.
Hachi, M., Ouafae, B., Hachi, T., Mohamed, E.B., Imane, B., Atmane, R., Zidane, L., Contribution to the ethnobotanical study of antidiabetic medicinal plants of the Central Middle Atlas region (Morocco). Lazaroa 37 (2016), 1–11.
Haciseferoğullari, H., Özcan, M.M., Duman, E., Biochemical and technological properties of seeds and oils of Capparis spinosa and Capparis ovata plants growing wild in Turkey. J. Food Process. Technol., 2, 2011.
Halder, M., Roy, S., Current status of metabolic engineering of medicinal plants for production of plant-derived secondary metabolites. Medicinal Plants: Biodiversity, Biotechnology and Conservation, 2023, Springer, 819–869.
Hammiche, V., Maiza, K., Traditional medicine in Central Sahara: pharmacopoeia of Tassili n'ajjer. J. Ethnopharmacol. 105 (2006), 358–367.
Hamuti, A., Li, Jinyu, Zhou, F., Aipire, A., Ma, J., Yang, J., Li, Jinyao, Capparis spinosa fruit ethanol extracts exert different effects on the maturation of dendritic cells. Molecules, 22, 2017, 97.
Hesami, M., Pepe, M., Baiton, A., Jones, A.M.P., Current status and future prospects in cannabinoid production through in vitro culture and synthetic biology. Biotechnol. Adv., 108074, 2022.
Hosseini, S.H., Sadeghi, Z., Hosseini, S.V., Bussmann, R.W., Ethnopharmacological study of medicinal plants in Sarvabad, Kurdistan province, Iran. J. Ethnopharmacol., 288, 2022, 114985.
Huseini, H.F., Hasani-Rnjbar, S., Nayebi, N., Heshmat, R., Sigaroodi, F.K., Ahvazi, M., Alaei, B.A., Kianbakht, S., Capparis spinosa L.(Caper) fruit extract in treatment of type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Compl. Ther. Med. 21 (2013), 447–452.
Idm'hand, E., Msanda, F., Cherifi, K., Ethnobotanical study and biodiversity of medicinal plants used in the Tarfaya Province, Morocco. Acta Ecol. Sin. 40 (2020), 134–144.
Ikeuchi, M., Sugimoto, K., Iwase, A., Plant Callus: Mechanisms of Induction and Repressionopen. 2013.
Infantino, A., Tomassoli, L., Peri, E., Colazza, S., Viruses, fungi and insect pests affecting caper. Eur. J. Plant Sci. Biotechnol. 1 (2007), 170–179.
Inocencio, C., Rivera, D., Obón, M.C., Alcaraz, F., Barreña, J.-A., A systematic revision of capparis section Capparis (Capparaceae) 1, 2. Ann. Mo. Bot. Gard. 93 (2006), 122–149.
Jamila, F., Mostafa, E., Ethnobotanical survey of medicinal plants used by people in Oriental Morocco to manage various ailments. J. Ethnopharmacol. 154 (2014), 76–87.
Jaradat, N.A., Shawahna, R., Eid, A.M., Al-Ramahi, R., Asma, M.K., Zaid, A.N., Herbal remedies use by breast cancer patients in the West Bank of Palestine. J. Ethnopharmacol. 178 (2016), 1–8.
Jiménez-López, J., Ruiz-Medina, A., Ortega-Barrales, P., Llorent-Martínez, E.J., Phytochemical profile and antioxidant activity of caper berries (Capparis spinosa L.): evaluation of the influence of the fermentation process. Food Chem. 250 (2018), 54–59.
Jouad, H., Haloui, M., Rhiouani, H., El Hilaly, J., Eddouks, M., Ethnobotanical survey of medicinal plants used for the treatment of diabetes, cardiac and renal diseases in the North centre region of Morocco (Fez–Boulemane). J. Ethnopharmacol. 77 (2001), 175–182.
Kabbaj, F., Meddah, B., Cherrah, Y., Faouzi, E., Ethnopharmacological profile of traditional plants used in Morocco by cancer patients as herbal therapeutics. Phytopharmacology 2 (2012), 243–256.
Kachmar, M.R., Naceiri Mrabti, H., Bellahmar, M., Ouahbi, A., Haloui, Z., El Badaoui, K., Bouyahya, A., Chakir, S., Traditional knowledge of medicinal plants used in the Northeastern part of Morocco. Evid. Based Comple. Alternat. Med., 2021, 2021.
Kahouadji, M.S., 1995. Contribution à une étude ethnobotanique des plantes médicinales dans le Maroc oriental. Diplôme d’études Supér. 3ème Cycle Univ. Mohamed Ier, Fac. Sci. Oujda, 220 pp.
Kalantari, H., Foruozandeh, H., Khodayar, M.J., Siahpoosh, A., Saki, N., Kheradmand, P., Antioxidant and hepatoprotective effects of Capparis spinosa L. Fractions and Quercetin on tert-butyl hydroperoxide-induced acute liver damage in mice. J. Tradit. Complement. Med. 8 (2018), 120–127.
Kantsa, A., Garcia, J.E., Raguso, R.A., Dyer, A.G., Steen, R., Tscheulin, T., Petanidou, T., Intrafloral patterns of color and scent in Capparis spinosa L. And the ghosts of its selection past. Am. J. Bot., 110, 2023, e16098.
Karami, M., Naghavi, M.R., Nasiri, J., Farzin, N., Methyl Jasmonate and β-cyclodextrin Shake Hands to Boost Withaferin A Production from the Hairy Root Culture of Withania Somnifera. 2023.
Karous, O., Ben Haj Jilani, I., Ghrabi-Gammar, Z., Ethnobotanical study on plant used by semi-nomad descendants' community in Ouled Dabbeb—Southern Tunisia. Plants, 10, 2021, 642.
Katiri, A., Barkaoui, M., Msanda, F., Boubaker, H., Ethnobotanical survey of medicinal plants used for the treatment of diabetes in the Tizi n'Test region (Taroudant Province, Morocco). J Pharmacogn Nat Prod, 3, 2017, 2472 0992.
Kdimy, A., El Yadini, M., Guaadaoui, A., Bourais, I., El Hajjaji, S., Le, H.V., Phytochemistry, biological activities, therapeutic potential, and socio-economic value of the caper bush (Capparis spinosa l.). Chem. Biodivers., 19, 2022, e202200300.
Kernouf, N., Bouriche, H., Kada, S., Messaoudi, D., Assaf, A.M., Senator, A., Anti-inflammatory and immuno-modulatory effects of Cpparis spinosa flower bud extract. Annu. Res. Rev. Biol., 1–11, 2018.
Khatib, M., Pieraccini, G., Innocenti, M., Melani, F., Mulinacci, N., An insight on the alkaloid content of Capparis spinosa L. Root by HPLC-DAD-MS, MS/MS and 1H qnmr. J. Pharm. Biomed. Anal. 123 (2016), 53–62.
Khavasi, N., hosein Somi, M., Khadem, E., Faramarzi, E., Ayati, M.H., Fazljou, S.M.B., Torbati, M., Effect of daily caper fruit pickle consumption on disease regression in patients with non-alcoholic fatty liver disease: a double-blinded randomized clinical trial. Adv. Pharmaceut. Bull., 7, 2017, 645.
Khavasi, N., Somi, M., Khadem, E., Ayati, M.H., Torbati, M., Fazljou, S.M.B., Daily consumption of the Capparis spinosa reduces some atherogenic indices in patients with non-alcoholic fatty liver disease: a randomized, double-blind, clinical trial. Iran. Red Crescent Med. J., 20, 2018.
Kianersi, F., Abdollahi, M.R., Mirzaie-asl, A., Dastan, D., Rasheed, F., Biosynthesis of rutin changes in Capparis spinosa due to altered expression of its pathway genes under elicitors' supplementation. Plant Cell Tissue Organ Cult. PCTOC 141 (2020), 619–631.
Kianersi, F., Abdollahi, M.R., Mirzaie-Asl, A., Dastan, D., Rasheed, F., Identification and tissue-specific expression of rutin biosynthetic pathway genes in Capparis spinosa elicited with salicylic acid and methyl jasmonate. Sci. Rep., 10, 2020, 8884.
Kirkan, B., Ceylan, O., Sarikürkcü, C., Bektas, T., Phenolic profile, antioxidant and enzyme inhibitory activity of the ethyl acetate, methanol and water extracts of Capparis spinosa L. Int. J. Second. Metab. 8 (2021), 337–351.
Kumari, K., Kumar, S., Jha, A.K., Kumar, N., Biotechnological intervention in genetic improvement and regulation of secondary metabolites production in Ocimum sanctum L. Ind. Crops Prod., 187, 2022, 115329.
Legua, P., Martínez, J.J., Melgarejo, P., Martínez, R., Hernández, F., Phenological growth stages of caper plant (Capparis spinosa L.) according to the Biologische Bundesanstalt, Bundessortenamt and Chemical scale. Ann. Appl. Biol. 163 (2013), 135–141 https://doi.org/10.1111/aab.12041.
Lev, E., Amar, Z., Ethnopharmacological survey of traditional drugs sold in the Kingdom of Jordan. J. Ethnopharmacol. 82 (2002), 131–145.
Liu, W., He, Y., Xiang, J., Fu, C., Yu, L., Zhang, J., Li, M., The physiological response of suspension cell of Capparis spinosa L. To drought stress. J. Med. Plants Res. 5 (2011), 5899–5906.
Lo Bosco, F., Guarrasi, V., Moschetti, M., Germanà, M.A., Butera, D., Corana, F., Papetti, A., Nutraceutical value of Pantelleria capers (Capparis spinosa L.). J. Food Sci. 84 (2019), 2337–2346.
Mahboubi, M., Mahboubi, A., Antimicrobial activity of Capparis spinosa as its usages in traditional medicine. Herba Pol., 60, 2014.
Mahmodi, N., Sharifi-Sirchi, G.-R., Cheghamirza, K., Evaluation of molecular and morphological diversity of caper (Capparis spinosa L.). Genet. Resour. Crop Evol. 69 (2022), 1509–1534.
Malarz, J., Yudina, Y.V., Stojakowska, A., Hairy root cultures as a source of phenolic antioxidants: simple phenolics, phenolic acids, Phenylethanoids, and Hydroxycinnamates. Int. J. Mol. Sci., 24, 2023, 6920.
Maresca, M., Micheli, L., Mannelli, L.D.C., Tenci, B., Innocenti, M., Khatib, M., Mulinacci, N., Ghelardini, C., Acute effect of Capparis spinosa root extracts on rat articular pain. J. Ethnopharmacol. 193 (2016), 456–465.
Mattalia, G., Paolo, C., Pieroni, A., The virtues of being peripheral, recreational, and transnational: local wild food and medicinal plant knowledge in selected remote municipalities of Calabria, Southern Italy. Ethnobot. Res. Appl., 19, 2020.
Matthäus, B., Özcan, M., Glucosinolates and fatty acid, sterol, and tocopherol composition of seed oils from Capparis spinosa Var. Spinosa and Capparis ovata Desf. Var. Canescens (Coss.) Heywood. J. Agric. Food Chem. 53 (2005), 7136–7141.
Mautone, M., De Martino, L., De Feo, V., Ethnobotanical research in Cava de'tirreni area, Southern Italy. J. Ethnobiol. Ethnomed. 15 (2019), 1–21.
Mazarei, F., Jooyandeh, H., Noshad, M., Hojjati, M., Polysaccharide of caper (Capparis spinosa L.) Leaf: extraction optimization, antioxidant potential and antimicrobial activity. Int. J. Biol. Macromol. 95 (2017), 224–231.
Mechaala, S., Bouatrous, Y., Adouane, S., Traditional knowledge and diversity of wild medicinal plants in El Kantara's area (Algerian Sahara gate): an ethnobotany survey. Acta Ecol. Sin. 42 (2022), 33–45.
Mehrnia, M., Akaberi, M., Amiri, M.S., Nadaf, M., Emami, S.A., Ethnopharmacological studies of medicinal plants in central Zagros, Lorestan Province, Iran. J. Ethnopharmacol., 280, 2021, 114080.
Melgarejo, P., Legua, P., Martinez, J.J., Martinez-Font, R., Hernandez, F., Preliminary characterization of sixty one caper clones (Capparis spinosa L.). Acta Hortic., 2009.
Mipeshwaree Devi, A., Khedashwori Devi, K., Premi Devi, P., Lakshmipriyari Devi, M., Das, S., Metabolic engineering of plant secondary metabolites: prospects and its technological challenges. Front. Plant Sci., 14, 2023, 1171154.
Moghadamnia, Y., Kani, S.N.M., Ghasemi-Kasman, M., Kani, M.T.K., Kazemi, S., The anti-cancer effects of Capparis spinosa hydroalcoholic extract. Avicenna J. Med. Biotechnol. (AJMB), 11, 2019, 43.
Mohaddab, M., El Goumi, Y., Gallo, M., Montesano, D., Zengin, G., Bouyahya, A., Fakiri, M., Biotechnology and in vitro culture as an alternative system for secondary metabolite production. Molecules, 27(22), 2022, 8093.
Mohebali, N., Shahzadeh Fazeli, S.A., Ghafoori, H., Farahmand, Z., mohammadkhani, E., Vakhshiteh, F., Ghamarian, A., Farhangniya, M., Sanati, M.H., Effect of flavonoids rich extract of Capparis spinosa on inflammatory involved genes in amyloid-beta peptide injected rat model of Alzheimer's disease. Nutr. Neurosci. 21 (2018), 143–150.
Mollica, A., Stefanucci, A., Macedonio, G., Locatelli, M., Luisi, G., Novellino, E., Zengin, G., Chemical composition and biological activity of Capparis spinosa L. From Lipari island. South Afr. J. Bot. 120 (2019), 135–140.
Mollica, A., Zengin, G., Locatelli, M., Stefanucci, A., Mocan, A., Macedonio, G., Carradori, S., Onaolapo, O., Onaolapo, A., Adegoke, J., Anti-diabetic and anti-hyperlipidemic properties of Capparis spinosa L.: in vivo and in vitro evaluation of its nutraceutical potential. J. Funct.Foods 35 (2017), 32–42.
Motolinía-Alcántara, E.A., Castillo-Araiza, C.O., Rodríguez-Monroy, M., Román-Guerrero, A., Cruz-Sosa, F., Engineering considerations to produce bioactive compounds from plant cell suspension culture in bioreactors. Plants, 10, 2021, 2762.
Motti, R., Wild plants used as herbs and spices in Italy: an ethnobotanical review. Plants, 10, 2021, 563.
Mughal, T.A., Ethnomedicinal Studies of Flora of Southern Punjab and Isolation of Biologically Active Principles (phd Thesis)., 2008, Lahore College For Women University, Lahore, Pakistan.
Mukhopadhyay, R., Micropropagation for the improved production of secondary metabolites. Plants Bioreact. Ind. Mol., 2023, 161–184.
Najafian, S., Mehregan, I., Iranbakhsh, A., Assadi, M., Fici, S., Species delimitation in Capparis (Capparaceae): morphological and molecular. Genetika 53 (2021), 609–627.
Nazer, M.R., Jahanbakhsh, S., Ebrahimi, K., Niazi, M., Sepahvand, M., Khatami, M., Kharazi, S., Cytotoxic and antileishmanial effects of various extracts of Capparis spinosa L. Turk. J. Pharm. Sci., 18, 2021, 146.
Oudah, S.K., Al-Salih, R.M., Gusar, S.H., Roomi, A.B., Study of the role of polyphenolic extract of Capparis spinosa L. Leaves as acute toxicity and antibacterial agent. Plant arch, 19, 2019 09725210.
Ouelbani, R., Bensari, S., Mouas, T.N., Khelifi, D., Ethnobotanical investigations on plants used in folk medicine in the regions of Constantine and Mila (North-East of Algeria). J. Ethnopharmacol. 194 (2016), 196–218.
Ouhammou, M., Adnany, E.M.E., Mourjane, A., Hammou, H.A., Bouchdoug, M., Jaouad, A., Mahrouz, M., Physico-chemical analysis and antioxidant activity of Moroccan caper leaves (Capparis spinosa L.). Euro-Mediterr. J. Environ. Integr. 7 (2022), 407–414.
Özcan, M., Pickling and storage of caperberries (Capparis spp.). Z. Für Leb. -Forsch. A 208 (1999), 379–382.
Özcan, M.M., Kanbur, G., Endes, Z. Leyha, Er, F., Fatty acid compositions of some oil-bearing plant seeds. Anal. Chem. Lett. 2 (2012), 235–239.
Pegiou, S., Raptis, P., Zafeiriou, I., Polidoros, A.N., Mylona, P.V., Genetic diversity and structure of Capparis spinosa L. Natural populations using morphological and molecular markers. J. Appl. Res. Med. Aromat. Plants, 34, 2023, 100487.
Peter, K.V., Handbook of Herbs and Spices, vol. 3, 2006, Abingt. Hall Abingt. Cambridgecb16ah Wood Head Publ. Ltd.
Pietrosiuk, A., Budzianowska, A., Budzianowski, J., Ekiert, H., Jeziorek, M., Kawiak, A., Kikowska, M., Krauze-Baranowska, M., Królicka, A., Kuźma, Lukasz, Polish achievements in bioactive compound production from in vitro plant cultures. Acta Soc. Bot. Pol., 91, 2022.
POWO. Plants of the World Online. 2021, Facilitated by the Royal Botanic Gardens, Kew Published on the Internet.
Rad, M.K., Ghani, A., Ghani, E., In vitro effects of Capparis spinosa L. Extract on human sperm function, DNA fragmentation, and oxidative stress. J. Ethnopharmacol., 269, 2021, 113702.
Rahimi, V.B., Rajabian, A., Rajabi, H., Vosough, E.M., Mirkarimi, H.R., Hasanpour, M., Iranshahi, M., Rakhshandeh, H., Askari, V.R., The effects of hydro-ethanolic extract of Capparis spinosa (C. Spinosa) on lipopolysaccharide (LPS)-induced inflammation and cognitive impairment: evidence from in vivo and in vitro studies. J. Ethnopharmacol., 256, 2020, 112706.
Rajhi, I., Ben Dhia, M.T., Abderrabba, M., Ouzari-Hadda, I., Ayadi, S., Phytochemical screening, in vitro antioxidant and antibacterial activities of methanolic extracts of Capparis Spionsa L. Different parts from Tunisia. J. Mater. Environ. Sci. 10 (2019), 234–243.
Rajhi, I., Hernandez-Ramos, F., Abderrabba, M., Ben Dhia, M.T., Ayadi, S., Labidi, J., Antioxidant, antifungal and phytochemical investigations of Capparis spinosa L. Agriculture, 11, 2021, 1025.
Rakhshandeh, H., Rashidi, R., Vahedi, M.M., Khorrami, M.B., Abbassian, H., Forouzanfar, F., Hypnotic activity of Capparis spinosa hydro-alcoholic extract in mice. Recent Pat. Food Nutr. Agric. 12 (2021), 58–62.
Ramdane, F., Mahammed, M.H., Hadj, M.D.O., Chanai, A., Hammoudi, R., Hillali, N., Mesrouk, H., Bouafia, I., Bahaz, C., Ethnobotanical study of some medicinal plants from Hoggar. Algeria. J. Med. Plants Res. 9 (2015), 820–827.
Ramdani, M., Lograda, T., Chalard, P., Chemical composition and antibacterial activities of Capparis spinosa essential oils from Algeria. Biodiversitas J. Biol. Divers., 21, 2020.
Rhimi, A., Mnasri, S., Ben Ayed, R., Bel Hajj Ali, I., Hjaoujia, S., Boussaid, M., Genetic relationships among subspecies of Capparis spinosa L. From Tunisia by using ISSR markers. Mol. Biol. Rep. 46 (2019), 2209–2219.
Rizza, L., D'Agostino, A., Girlando, A., Puglia, C., Evaluation of the effect of topical agents on radiation-induced skin disease by reflectance spectrophotometry. J. Pharm. Pharmacol. 62 (2010), 779–785.
Rogowska, A., Pączkowski, C., Szakiel, A., Modifications in steroid and triterpenoid metabolism in Calendula officinalis plants and hairy root culture in response to chitosan treatment. BMC Plant Biol. 23 (2023), 1–18.
Rohini, M.R., Rajasekharan, P.E., Scale-up production of bioactive compounds using bioreactors. Nutraceuticals Production from Plant Cell Factory, 2022, Springer, 69–81.
Saberi, M., Kamali, N., Tarnian, F., Sadeghipour, A., Investigation phenol, flavonoids and antioxidant activity content of Capparis spinosa in three natural habitats of sistan and baluchestan province, Iran. J. Rangeland Sci. 12:2 (2022), 191–204, 10.30495/rs.2022.682941.
Safarzaei, A., Sarhadi, H., Khodaparast, M.H.H., Shahdadi, F., Dashipour, A.R., Optimization of aqueous and alcoholic extraction of phenolic and antioxidant compounds from Caper (Capparis spinosa L.) Roots assisted by ultrasound waves. Zahedan J. Res. Med. Sci., 22, 2020.
Said, O., Khalil, K., Fulder, S., Azaizeh, H., Ethnopharmacological survey of medicinal herbs in Israel, the golan heights and the west bank region. J. Ethnopharmacol. 83 (2002), 251–265.
Saifi, N., Ibijbijen, J., Echchgadda, D., Genetic diversity of caper plant (Capparis ssp.) from North Morocco. J. Food Agric. Environ. 9 (2011), 299–304.
Saleem, H., Khurshid, U., Sarfraz, M., Ahmad, I., Alamri, A., Anwar, S., Alamri, A.S., Locatelli, M., Tartaglia, A., Mahomoodally, M.F., Investigation into the biological properties, secondary metabolites composition, and toxicity of aerial and root parts of Capparis spinosa L.: an important medicinal food plant. Food Chem. Toxicol., 155, 2021, 112404.
Sardari, S., Fallahi, F., Emadi, F., Davati, A., Khavasi, N., Gholamifesharaki, M., Esmaeili, S.S., Daily consumption of caper fruit along with atorvastatin has synergistic effects in hyperlipidemic patients: randomized Clinical trial. Galen Med. J., 8, 2019, e1345.
Sargin, S.A., Selvi, S., Lopez, V., Ethnomedicinal plants of sarigöl district (manisa), Turkey. J. Ethnopharmacol. 171 (2015), 64–84.
Sathish, S., Vasudevan, V., Karthik, S., Pavan, G., Siva, R., Manickavasagam, M., Precursor feeding enhances L-Dopa production in hairy root culture of Hybanthus enneaspermus (L.) F. Muell. Biologia (Bratisl.) 78 (2023), 913–923.
Shahrajabian, M.H., Sun, W., Cheng, Q., Plant of the Millennium, Caper (Capparis spinosa L.), chemical composition and medicinal uses. Bull. Natl. Res. Cent. 45 (2021), 1–9.
Sher, H., Alyemeni, M.N., Ethnobotanical and pharmaceutical evaluation of Capparis spinosa L, validity of local folk and Unani system of medicine. J. Med. Plants Res. 4 (2010), 1751–1756.
Singh, K.N., Lal, B., Ethnomedicines used against four common ailments by the tribal communities of Lahaul-Spiti in western Himalaya. J. Ethnopharmacol. 115 (2008), 147–159.
Singh, S., Pandey, P., Akhtar, M.Q., Negi, A.S., Banerjee, S., A new synthetic biology approach for the production of curcumin and its glucoside in Atropa belladonna hairy roots. J. Biotechnol. 328 (2021), 23–33.
Sonkar, N., Shukla, P.K., Misra, P., Plant hairy roots as biofactory for the production of industrial metabolites. Plants Bioreact. Ind. Mol., 2023, 273–297.
Sonmezdag, A.S., Kelebek, H., Selli, S., Characterization of aroma-active compounds, phenolics, and antioxidant properties in fresh and fermented capers (Capparis spinosa) by GC-MS-olfactometry and LC-DAD-ESI-MS/MS. J. Food Sci. 84 (2019), 2449–2457.
Sottile, F., Caltagirone, C., Peano, C., Del Signore, M.B., Barone, E., Can the caper (Capparis spinosa L.) Still be considered a difficult-to-propagate crop?. Horticulturae, 7, 2021, 316.
Sozzi, G.O., Caper bush: botany and horticulture. Hortic. Rev.-Westport Then N. Y.- 27 (2001), 125–188.
Sozzi, G.O., Peter, K.V., Babu, K.N., Divakaran, M., Capers and caperberries. Handbook of Herbs and Spices, 2012, Elsevier, 193–224.
Sreelekshmi, R., Swapna, T.S., Siril, E.A., In vitro secondary metabolite production for sustainable utilization of endangered medicinal plants. Conservation and Sustainable Utilization of Bioresources, 2023, Springer, 451–471.
Stefanucci, A., Zengin, G., Locatelli, M., Macedonio, G., Wang, C.-K., Novellino, E., Mahomoodally, M.F., Mollica, A., Impact of different geographical locations on varying profile of bioactives and associated functionalities of caper (Capparis spinosa L.). Food Chem. Toxicol. 118 (2018), 181–189.
Syklowska-Baranek, K., Gawel, M., Kuźma, Lukasz, Wileńska, B., Kawka, M., Jeziorek, M., Graikou, K., Chinou, I., Szyszko, E., Stępień, P., Rindera graeca (A. DC.) boiss. & heldr.(boraginaceae) in vitro cultures targeting lithospermic acid B and rosmarinic acid production. Molecules, 28, 2023, 4880.
Tahraoui, A., El-Hilaly, J., Israili, Z.H., Lyoussi, B., Ethnopharmacological survey of plants used in the traditional treatment of hypertension and diabetes in south-eastern Morocco (Errachidia province). J. Ethnopharmacol. 110 (2007), 105–117.
Taibi, K., Abderrahim, L.A., Boussaid, M., Taibi, F., Achir, M., Souana, K., Benaissa, T., Farhi, K.H., Naamani, F.Z., Said, K.N., Unraveling the ethnopharmacological potential of medicinal plants used in Algerian traditional medicine for urinary diseases. Eur. J. Integr. Med., 44, 2021, 101339.
Taibi, K., Abderrahim, L.A., Ferhat, K., Betta, S., Taïbi, F., Bouraada, F., Boussaid, M., Ethnopharmacological study of natural products used for traditional cancer therapy in Algeria. Saudi Pharmaceut. J. 28 (2020), 1451–1465, 10.1016/j.jsps.2020.09.011.
Tir, M., Feriani, A., Labidi, A., Mufti, A., Saadaoui, E., Nasri, N., Khaldi, A., El Cafsi, M., Tlili, N., Protective effects of phytochemicals of Capparis spinosa seeds with cisplatin and ccl4 toxicity in mice. Food Biosci. 28 (2019), 42–48.
Tlili, N., Elfalleh, W., Saadaoui, E., Khaldi, A., Triki, S., Nasri, N., The caper (Capparis L.): ethnopharmacology, phytochemical and pharmacological properties. Fitoterapia 82 (2011), 93–101.
Tlili, N., Feriani, A., Saadoui, E., Nasri, N., Khaldi, A., Capparis spinosa leaves extract: source of bioantioxidants with nephroprotective and hepatoprotective effects. Biomed. Pharmacother. 87 (2017), 171–179.
Tlili, N., Khaldi, A., Triki, S., Munné-Bosch, S., Phenolic compounds and vitamin antioxidants of caper (Capparis spinosa). Plant Foods Hum. Nutr. 65 (2010), 260–265.
Tlili, N., Nasri, N., Khaldi, A., Triki, S., Munné-bosch, S., Phenolic compounds, tocopherols, carotenoids and vitamin C of commercial caper. J. Food Biochem. 35 (2011), 472–483.
Ugulu, I., Baslar, S., Yorek, N., Dogan, Y., The investigation and quantitative ethnobotanical evaluation of medicinal plants used around Izmir province, Turkey. J. Med. Plants Res. 3 (2009), 345–367.
Vahid, H., Rakhshandeh, H., Ghorbani, A., Antidiabetic properties of Capparis spinosa L. And its components. Biomed. Pharmacother. 92 (2017), 293–302.
Verpoorte, R., Contin, A., Memelink, J., Biotechnology for the production of plant secondary metabolites. Phytochemistry Rev. 1 (2002), 13–25.
Vivek, A.S., Riyas, C.T., Swapna, T.S., Enhanced secondary metabolite production for drug leads. Conservation and Sustainable Utilization of Bioresources, 2023, Springer, 473–504.
Wang, L., Fan, L., Zhao, Z., Zhang, Z., Jiang, L., Chai, M., Tian, C., The Capparis spinosa var. Herbacea genome provides the first genomic instrument for a diversity and evolution study of the Capparaceae family. GigaScience, 11, 2022, giac106.
Wang, Q., Zhang, M.-L., Yin, L.-K., Genetic diversity and population differentiation of Capparis spinosa (Capparaceae) in Northwestern China. Biochem. Systemat. Ecol. 66 (2016), 1–7.
Wang, Y.T., Gan, L., Liu, W., Yu, L.J., Li, M.T., Research on the callus inducing and the cell growth and metabolism characteristics of Capparis spinosa L. Coll. Life Sci Technolo Huazhong Univ Sci Technolo Wuhan China 7 (2007), 1779–1783.
Wojdyło, A., Nowicka, P., Grimalt, M., Legua, P., Almansa, M.S., Amorós, A., Carbonell-Barrachina, Á.A., Hernández, F., Polyphenol compounds and biological activity of caper (Capparis spinosa L.) Flowers buds. Plants, 8, 2019, 539.
Yahia, Y., Benabderrahim, M.A., Tlili, N., Hannachi, H., Ayadi, L., Elfalleh, W., Comparison of three extraction protocols for the characterization of caper (Capparis spinosa L.) Leaf extracts: evaluation of phenolic acids and flavonoids by liquid chromatography–electrospray ionization–tandem mass spectrometry (LC–ESI–MS) and the antioxidant activity. Anal. Lett. 53 (2020), 1366–1377.
Yan, M., Li, J., Liu, H., Yang, N., Chu, J., Sun, L., Bi, X., Lin, R., Lv, G., In vitro efficacy of Capparis spinosa extraction against larvae viability of Echinococcus granulosus sensu stricto. J. Vet. Med. Sci. 84 (2022), 465–472.
Yan, Y., Huang, X., Shen, Q., Hu, R., Wang, P., Yan, M., Di, P., Wang, Y., Establishment of Hairy Roots Culture of Perilla Frutescens L. And Production of Phenolic Acids. 2023.
Yang, T., Wang, C., Chou, G., Wu, T., Cheng, X., Wang, Z., New alkaloids from Capparis spinosa: structure and X-ray crystallographic analysis. Food Chem. 123 (2010), 705–710.
Yang, T., Wang, Y.-L., Zhang, Y.-L., Liu, Y.-T., Tao, Y.-Y., Zhou, H., Liu, C.-H., The protective effect of Capparis spinosa fruit on triptolide-induced acute liver injury: a metabolomics-based systematic study. J. Funct.Foods, 90, 2022, 104989.
Yin, Y., He, Y., Liu, W., Gan, L., Fu, C., Jia, H., Li, M., The durative use of suspension cells and callus for volatile oil by comparative with seeds and fruits in Capparis spinosa L. PLoS One, 9, 2014, e113668.
Yue, W., Ming, Q., Lin, B., Rahman, K., Zheng, C.-J., Han, T., Qin, L., Medicinal plant cell suspension cultures: pharmaceutical applications and high-yielding strategies for the desired secondary metabolites. Crit. Rev. Biotechnol. 36 (2016), 215–232.
Zarei, M., Seyedi, N., Maghsoudi, S., Nejad, M.S., Sheibani, H., Green synthesis of Ag nanoparticles on the modified graphene oxide using Capparis spinosa fruit extract for catalytic reduction of organic dyes. Inorg. Chem. Commun., 123, 2021, 108327.
Zhou, H., Jian, R., Kang, J., Huang, X., Li, Y., Zhuang, C., Yang, F., Zhang, L., Fan, X., Wu, T., Anti-inflammatory effects of caper (Capparis spinosa L.) Fruit aqueous extract and the isolation of main phytochemicals. J. Agric. Food Chem. 58 (2010), 12717–12721.
Zhu, P., Wang, Y., Zhang, X., Preparation and characterization of electrospun nanofibre membranes incorporated with an ethanol extract of Capparis spinosa L. As a potential packaging material. Food Packag. Shelf Life, 32, 2022, 100851.
Zhu, X., Yang, Y., Gao, W., Jiang, B., Shi, L., Capparis spinosa alleviates DSS-induced ulcerative colitis via regulation of the gut microbiota and oxidative stress. Evid. Based Comple. Alternat. Med., 2021, 2021.
Ziyyat, A., Legssyer, A., Mekhfi, H., Dassouli, A., Serhrouchni, M., Benjelloun, W., Phytotherapy of hypertension and diabetes in oriental Morocco. J. Ethnopharmacol. 58 (1997), 45–54.
Zohary, M., The species of Capparis in the mediterranean and the near eastern countries. Bull. Res. Counc. Isr, 1960, 49–64.