Track Sealing in CT-Guided Lung Biopsy Using Gelatin Sponge Slurry versus Saline in Reducing Postbiopsy Pneumothorax: A Prospective Randomized Study.

[en] [en] PURPOSE: To compare the effectiveness of 2 track sealing techniques following computed tomography (CT)-guided lung biopsy using either gelatin sponge slurry (GSS) or saline to reduce the rate of postbiopsy pneumothorax. MATERIALS AND METHODS: In this prospective study, a total of 266 patients (median age, 66.2 years; range, 25.5-89.2 years; 150 men) were included between July 2019 and January 2023. The patients referred for a CT-guided lung biopsy, in whom the needle would pass through aerated lung, were randomly assigned to either the GSS sealing technique group (n = 132) or the saline track sealing technique (n = 134) in a 1:1 ratio. All biopsies were performed using a 19-gauge coaxial needle in a tertiary hospital by 1 of 4 interventional radiologists with varying levels of experience (F.C., L.G., P.L., C.V.). The outcomes were pneumothorax occurrence, pneumothorax-related intervention (simple aspiration and/or drainage), and biopsy-related hospital stay length. RESULTS: Pneumothorax rates were 12.1% in the GSS group and 24.6% in the saline group (P = .008). Hospital length of stay was significantly shorter in the GSS group (P = .003). The need for pneumothorax-related intervention did not reach statistical significance between the groups (6.8% vs 12.7%; P = .107). In the multiple logistic regression analysis, track sealing with GSS was a protective factor for pneumothorax (odds ratio [OR], 0.44; 95% CI, 0.22-0.87; P = .019), and emphysema was associated with higher risk of pneumothorax (OR, 2.67; 95% CI, 1.31-5.44; P = .007). CONCLUSIONS: Track sealing with GSS following a CT-guided lung biopsy is significantly more effective than saline in reducing postbiopsy pneumothorax and results in shorter hospital stay.

Disciplines :

Radiology, nuclear medicine & imaging

Author, co-author :

Dheur, Sophie ; Centre Hospitalier Universitaire de Liège - CHU > > Service médical de radiodiagnostic

GERARD, Laurent ; Centre Hospitalier Universitaire de Liège - CHU > > Service médical de radiodiagnostic

Lamborelle, Pierre; Department of Imaging, University Hospital of Liège, Liège, Belgium

VALKENBORGH, Christophe ; Centre Hospitalier Universitaire de Liège - CHU > > Service médical de radiodiagnostic

Grandjean, Flavien ; Centre Hospitalier Universitaire de Liège - CHU > > Service médical de radiodiagnostic

GILLARD, Romain ; Centre Hospitalier Universitaire de Liège - CHU > > Service médical de radiodiagnostic

Dardenne, Nadia ; Université de Liège - ULiège > Département des sciences de la santé publique

Hustinx, Roland ; Université de Liège - ULiège > Département des sciences cliniques > Médecine nucléaire

Cousin, François ; Université de Liège - ULiège > Département des sciences cliniques

Language :

English

Title :

Track Sealing in CT-Guided Lung Biopsy Using Gelatin Sponge Slurry versus Saline in Reducing Postbiopsy Pneumothorax: A Prospective Randomized Study.

Publication date :

27 July 2024

Journal title :

Journal of Vascular and Interventional Radiology

ISSN :

1051-0443

eISSN :

1535-7732

Publisher :

Elsevier BV, United States

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:S1051044324004949?httpAccept=text/xml

Available on ORBi :

since 25 October 2024

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