[en] Background: Abdominal aortic aneurysm (AAA) is a life-threatening condition due to the risk of aneurysm growth and rupture. Biomarkers linked to AAA pathogenesis are attractive candidates for AAA diagnosis and prognosis. The aim of this study was to assess circulating biomarkers levels relationship with PET imaging positivity and their predictive value in AAA growth rate. Methods: A total of 164 patients with AAA had whole body [18F]FDG PET/CT examination and blood drawn for biomarkers analysis at inclusion. Of these, 121 patients had at least one follow-up imaging assessment for AAA progression. Median (quartiles) imaging follow-up period was 32.8 months (15.2-69.6 months). Results: At baseline, PET was visually positive in 28 (17%) patients. Among PET+ patients, female proportion was higher compared to PET-patients (respectively, n = 6, 21.4% vs. n = 11, 8.1%, p = 0.046). Biomarkers of inflammation (CRP, CCL18), of proteolytic activity (MMP9), of extracellular matrix, and calcification regulation (OPN, OPG) were all significantly increased in PET+ patients (p < 0.05). During follow-up, rapid AAA growth (increase in size ≥ 1 cm per year) was observed in 36 (29.8%) patients and several biomarkers (CRP, MMP9, OPN, and OPG) were increased in those patients compared to patients without rapid growth (p < 0.05). Conclusions: Although PET positivity at baseline was not associated with rapid growth, CRP levels showed a significant association.
MUSUMECI, Lucia ; Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie cardio-vasculaire et thoracique
Courtois, Audrey; Surgical Research Center (GIGA-Cardiovascular Science Unit), University Hospital of Liège, 4000 Liège, Belgium
Hustinx, Roland ; Université de Liège - ULiège > Département des sciences cliniques > Médecine nucléaire
SAKALIHASAN, Sarah ; Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine - Pool assistants
Namur, Gauthier ; Université de Liège - ULiège > Département des sciences cliniques ; Department of Nuclear Medicine, CHC Mont-Légia, 4000 Liège, Belgium
Defraigne, Jean-Olivier ; Université de Liège - ULiège > Département des sciences cliniques > Chirurgie thoracique
Sakalihasan, Natzi ; Université de Liège - ULiège > Département des sciences cliniques
Language :
English
Title :
Can Biomarkers and PET Imaging Predict Abdominal Aortic Aneurysm Growth Rate?
Publication date :
22 April 2024
Journal title :
Journal of Clinical Medicine
eISSN :
2077-0383
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Switzerland
EU - European Union Fonds pour la Chirurgie Cardiaque Aneurysmal Pathology Foundation
Funding text :
This work was supported by: the European Program FP7 \u201CFighting aneurysmal diseases\u201D (no. 200647); the Belgian Fonds pour la Chirurgie Cardiaque; the Aneurysmal Pathology Foundation Liege-Belgium, which founded A. Courtois.
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