Influence of physicochemical characteristics of calcium phosphate-based biomaterials in cranio-maxillofacial bone regeneration. A systematic literature review and meta-analysis of preclinical models.

Sadeghian Dehkord, Ehsan; DE CARVALHO, Bruno; Ernst, Marie; Albert, Adelin; Lambert, France; Geris, Liesbet

doi:10.1016/j.mtbio.2024.101100

Article (Scientific journals)

Influence of physicochemical characteristics of calcium phosphate-based biomaterials in cranio-maxillofacial bone regeneration. A systematic literature review and meta-analysis of preclinical models.

Sadeghian Dehkord, Ehsan; DE CARVALHO, Bruno; Ernst, Marie et al.

2024 • In Materials Today Bio, 26, p. 101100

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/323819

DOI
10.1016/j.mtbio.2024.101100

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38854953

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Keywords :

Animal study; Biomaterials; Bone defect; Bone regeneration; Bone scaffold; Calcium phosphate; Cranio-maxillofacial; Intra-oral bone formation; Physicochemical; Preclinical; Animal studies; Bone formation; Bone scaffolds; Physico-chemicals; Physicochemical characteristics; Biotechnology; Bioengineering; Biomedical Engineering; Molecular Biology; Cell Biology

Abstract :

[en] [en] OBJECTIVES: Calcium phosphate-based biomaterials (CaP) are the most widely used biomaterials to enhance bone regeneration in the treatment of alveolar bone deficiencies, cranio-maxillofacial and periodontal infrabony defects, with positive preclinical and clinical results reported. This systematic review aimed to assess the influence of the physicochemical properties of CaP biomaterials on the performance of bone regeneration in preclinical animal models. METHODS: The PubMed, EMBASE and Web of Science databases were searched to retrieve the preclinical studies investigating physicochemical characteristics of CaP biomaterials. The studies were screened for inclusion based on intervention (physicochemical characterization and in vivo evaluation) and reported measurable outcomes. RESULTS: A total of 1532 articles were retrieved and 58 studies were ultimately included in the systematic review. A wide range of physicochemical characteristics of CaP biomaterials was found to be assessed in the included studies. Despite a high degree of heterogeneity, the meta-analysis was performed on 39 studies and evidenced significant effects of biomaterial characteristics on their bone regeneration outcomes. The study specifically showed that macropore size, Ca/P ratio, and compressive strength exerted significant influence on the formation of newly regenerated bone. Moreover, factors such as particle size, Ca/P ratio, and surface area were found to impact bone-to-material contact during the regeneration process. In terms of biodegradability, the amount of residual graft was determined by macropore size, particle size, and compressive strength. CONCLUSION: The systematic review showed that the physicochemical characteristics of CaP biomaterials are highly determining for scaffold's performance, emphasizing its usefulness in designing the next generation of bone scaffolds to target higher rates of regeneration.

Research Center/Unit :

d‐BRU - Dental Biomaterials Research Unit - ULiège

Disciplines :

Dentistry & oral medicine

Author, co-author :

Sadeghian Dehkord, Ehsan ; Université de Liège - ULiège > GIGA ; Prometheus, The R&D Division for Skeletal Tissue Engineering, KU Leuven, Belgium

DE CARVALHO, Bruno ; Centre Hospitalier Universitaire de Liège - CHU > > Service de parodontologie, chirurgie bucco-dentaire et chirurgie implantaire

Ernst, Marie ; Centre Hospitalier Universitaire de Liège - CHU > > Service des informations médico économiques (SIME)

Albert, Adelin ; Université de Liège - ULiège > Département des sciences de la santé publique

Lambert, France ; Université de Liège - ULiège > Département des sciences dentaires > Chirurgie bucco-dentaire et parodontologie

Geris, Liesbet ; Université de Liège - ULiège > Département d'aérospatiale et mécanique > Génie biomécanique ; Prometheus, The R&D Division for Skeletal Tissue Engineering, KU Leuven, Belgium ; Department of Mechanical Engineering, Biomechanics Section (BMe), KU Leuven, Belgium

Language :

English

Title :

Influence of physicochemical characteristics of calcium phosphate-based biomaterials in cranio-maxillofacial bone regeneration. A systematic literature review and meta-analysis of preclinical models.

Publication date :

June 2024

Journal title :

Materials Today Bio

eISSN :

2590-0064

Publisher :

Elsevier B.V., England

Volume :

Pages :

101100

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:S2590006424001595?httpAccept=text/xml

Funding text :

This project received funding from the European Research Council under the European Union\u2019s Horizon Europe programme / ERC Consolidator Grant No. 101088919, and from the Walloon Region via the BIOWIN-BIOPTOS and Win2Wal-B2Bone project. We are grateful to Dr. Bert Avau (Centre for Evidence-Based Practice (CEBaP)) for his skillful support and assistance. We also acknowledge the kind support from Dr. Krizia Tuand and Dr. Kristel Paque (KU Leuven Bibliotheken).The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Liesbet Geris reports financial support was provided by European Research Council under the European Union's Horizon Europe programme/ERC Consolidator Grant No. 101088919. Liesbet Geris and France Lambert report financial support was provided by Walloon Region via the BIOWIN-BIOPTOS and Win2Wal-B2Bone projects. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.This project received funding from the European Research Council under the European Union's Horizon Europe programme/ERC Consolidator Grant No. 101088919, and from the Walloon Region via the BIOWIN-BIOPTOS and Win2Wal-B2Bone project. We are grateful to Dr. Bert Avau (Centre for Evidence-Based Practice (CEBaP)) for his skillful support and assistance. We also acknowledge the kind support from Dr. Krizia Tuand and Dr. Kristel Paque (KU Leuven Bibliotheken).

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