Sulfamides et granulations de Heinz

In vitro, experiments on sulfonamides show that these substances are without action on the red cells, in respect to the formation of Heinz's corpuscles, at the blood concentration generally obtained in therapeutic practice. In vivo, the presence of Heinz's granules was noted after the injection of large sulfanilamide doses in the white mouse, but not after the administration of sulfopyridine and sulfathiazole. Therapeutical doses of all these drugs did not give rise to Heinz's corpuscles in several patients. © 1947 Birkhäuser Verlag.