An emerging mechanism for the maturation of the Small Subunit Processome.

Ribosomal Proteins; Saccharomyces cerevisiae Proteins; Cryoelectron Microscopy; Eukaryotic Cells; Ribosomal Proteins/chemistry; Ribosome Subunits, Small/chemistry; Ribosomes

Abstract :

[en] The biogenesis of the eukaryotic ribosome is a tightly regulated and energetically demanding process involving more than 200 ribosome assembly factors. These factors work in concert to ensure accurate assembly and maturation of both ribosomal subunits. Cryo-electron microscopy (cryo-EM) structures of numerous eukaryotic ribosome assembly intermediates have provided a wealth of structural insights highlighting the molecular interplay of a cast of assembly factors. In this review, we focus on recently determined structures of maturing small subunit (SSU) processomes, giant precursors of the small ribosomal subunit. Based on these structures and complementary biochemical and genetic studies, we discuss an emerging mechanism involving exosome-mediated SSU processome maturation and disassembly.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Vanden Broeck, Arnaud ; Laboratory of Protein and Nucleic Acid Chemistry, The Rockefeller University, New York, NY 10065, USA. Electronic address: https://twitter.com/AVBroeck.

Klinge, Sebastian; Laboratory of Protein and Nucleic Acid Chemistry, The Rockefeller University, New York, NY 10065, USA. Electronic address: klinge@rockefeller.edu.

Language :

English

Title :

An emerging mechanism for the maturation of the Small Subunit Processome.

Publication date :

April 2022

Journal title :

Current Opinion in Structural Biology

ISSN :

0959-440X

Volume :

Pages :

102331

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 15 October 2024

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Bibliography

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