[en] The increasing challenge of antimicrobial resistance and the persistent threat of infectious diseases are strong incentives for development of novel materials that effectively and sustainably combat bacterial proliferation. Macroporous materials contribute to this endeavor, but the reported antibacterial porous polymers rely on the release of antibacterial agents, which carries the risk that their efficacy will diminish over time. This work reports a facile synthesis by emulsion templating polymerization of innovative photo-bactericidal macroporous polymers functionalized by a quinizarin photosensitizer that generates antibacterial reactive oxygen species under visible light. In brief, a monomethacrylated quinizarin (QMA) derivative, known for its ability to generate bactericidal singlet oxygen upon visible light irradiation, is copolymerized with a bio-based acrylated epoxidized soybean oil (AESO) under high internal phase emulsion (HIPE) conditions, resulting in 3D-interconnected quinizarin-functionalized macroporous monoliths. The QMA-functionalized polyHIPEs are also structured into membranes by photocuring thin layers of HIPEs to increase their external surface and promote interaction with light. Photobleaching tests show the ability of these materials to generate bactericidal singlet oxygen. Antibacterial tests also demonstrate the sustained antibacterial efficacy of the QMA-based porous membranes, providing a promising avenue for the development of next-generation antibacterial materials.
Research Center/Unit :
CESAM - Complex and Entangled Systems from Atoms to Materials - ULiège CERM - Center for Education and Research on Macromolecules - ULiège
Disciplines :
Materials science & engineering Chemistry
Author, co-author :
Hayek, Hassan ✱; University Paris-Est Créteil [UPEC] - CNRS - ICMPE - Thais - France
Rouxhet, Alison ✱; University of Liège [ULiège] - Complex and Entangled Systems from Atoms to Materials [CESAM] Research Unit - Center for Education and Research on Macromolecules [CERM] - Belgium
Abbad Andaloussi, Samir; University Paris-Est Créteil [UPEC] - Laboratoire Eau, Environnement, Systèmes Urbains [LEESU] - Créteil - France
Kovačič, Sebastijan ; University of Maribor - Faculty of Chemistry and Chemical Engineering - Slovenia ; National Institute of Chemistry - Ljubljana -Slovenia
Versace, Davy-Louis ; University Paris-Est Créteil [UPEC] - CNRS - ICMPE - Thais - France
Debuigne, Antoine ; University of Liège [ULiège] - Complex and Entangled Systems from Atoms to Materials [CESAM] Research Unit - Center for Education and Research on Macromolecules [CERM] - Belgium
✱ These authors have contributed equally to this work.
Language :
English
Title :
Quinizarin-based photoactive porous polymers from emulsion templates: Monoliths versus membranes in photobactericidal applications
Publication date :
19 August 2024
Journal title :
European Polymer Journal
ISSN :
0014-3057
eISSN :
1873-1945
Publisher :
Elsevier Ltd
Volume :
217
Pages :
113291
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique
Funding text :
A.D. is FNRS Senior Research Associate and thanks the F.R.S.-FNRS for financial support. S.K. acknowledges the financial support of the Ministry of Higher Education, Science and Innovation of the Republic of Slovenia and the Slovenian Research and Innovation Agency (grant P2-0150 ) and the financial support of the Horizon Europe project UPSTREAM ( GA 10112877 ). A.D. is grateful to P. Boucq and M. Ducrocq for skillful assistance.
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