[en] Disentangling how cognitive functions emerge from the interplay of brain dynamics and network architecture is among the major challenges that neuroscientists face. Pharmacological and pathological perturbations of consciousness provide a lens to investigate these complex challenges. Here, we review how recent advances about consciousness and the brain's functional organisation have been driven by a common denominator: decomposing brain function into fundamental constituents of time, space, and information. Whereas unconsciousness increases structure-function coupling across scales, psychedelics may decouple brain function from structure. Convergent effects also emerge: anaesthetics, psychedelics, and disorders of consciousness can exhibit similar reconfigurations of the brain's unimodal-transmodal functional axis. Decomposition approaches reveal the potential to translate discoveries across species, with computational modelling providing a path towards mechanistic integration.
Disciplines :
Neurosciences & behavior
Author, co-author :
Luppi, Andrea I ; Division of Anaesthesia, University of Cambridge, Cambridge, UK, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK, Montreal Neurological Institute, McGill University, Montreal, QC, Canada, St John's College, University of Cambridge, Cambridge, UK, Center for Eudaimonia and Human Flourishing, Linacre College, University of Oxford, Oxford, UK. Electronic address: al857@cam.ac.uk
Rosas, Fernando E; Center for Eudaimonia and Human Flourishing, Linacre College, University of Oxford, Oxford, UK, Department of Informatics, University of Sussex, Brighton, UK, Center for Psychedelic Research, Imperial College London, London, UK
Mediano, Pedro A M; Department of Computing, Imperial College London, London, UK
Demertzi, Athina ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Physiology of Cognition
Menon, David K; Division of Anaesthesia, University of Cambridge, Cambridge, UK
Stamatakis, Emmanuel A; Division of Anaesthesia, University of Cambridge, Cambridge, UK, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
Language :
English
Title :
Unravelling consciousness and brain function through the lens of time, space, and information.
The authors gratefully acknowledge the support of the Gates Cambridge Scholarship (OPP 1144, to A.I.L.); Stephen Erskine Fellowship of Queens\u2019 College, Cambridge (to E.A.S.); Canadian Institute for Advanced Research (CIFAR; grant RCZB/072 RG93193) (to D.K.M. and E.A.S.); Cambridge Biomedical Research Centre and NIHR Senior Investigator Awards and the British Oxygen Professorship of the Royal College of Anaesthetists (to D.K.M.). A.D. is supported by the Belgian Fund for Scientific Research (FRS-FNRS), the EU's Horizon 2020 Research and Innovation Marie Sk\u0142odowska-Curie RISE programme NeuronsXnets (grant agreement 101007926), the European Cooperation in Science and Technology COST Action (CA18106), the L\u00E9on Fredericq Foundation, and the University of Li\u00E8ge and University Hospital of Li\u00E8ge. A.I.L. is grateful for the mentorship of Bratislav Misic and Morten Kringelbach and the support of Robert Tasker. The authors are also grateful to Jakub Vohryzek, Selen Atasoy, Petra Vertes, Rodrigo Cofre, and Daniel Bor for many helpful discussions. The authors have no competing interests to declare.The authors gratefully acknowledge the support of the Gates Cambridge Scholarship ( OPP 1144 , to A.I.L.); Stephen Erskine Fellowship of Queens\u2019 College, Cambridge (to E.A.S.); Canadian Institute for Advanced Research (CIFAR; grant RCZB/072 RG93193 ) (to D.K.M. and E.A.S.); Cambridge Biomedical Research Centre and NIHR Senior Investigator Awards and the British Oxygen Professorship of the Royal College of Anaesthetists (to D.K.M.). A.D. is supported by the Belgian Fund for Scientific Research (FRS-FNRS), the EU\u2019s Horizon 2020 Research and Innovation Marie Sk\u0142odowska-Curie RISE programme NeuronsXnets (grant agreement 101007926 ), the European Cooperation in Science and Technology COST Action ( CA18106 ), the L\u00E9on Fredericq Foundation , and the University of Li\u00E8ge and University Hospital of Li\u00E8ge . A.I.L. is grateful for the mentorship of Bratislav Misic and Morten Kringelbach. The authors are also grateful to Jakub Vohryzek, Selen Atasoy, and Daniel Bor for many helpful discussions.
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