Animals; Cattle/genetics; Phenotype; Mite Infestations/veterinary; Mite Infestations/genetics; Polymorphism, Single Nucleotide; Genomics/methods; Genetic Predisposition to Disease; Genome-Wide Association Study/methods; Genome-Wide Association Study/veterinary; Psoroptidae/genetics; Cattle Diseases/genetics; Cattle; Cattle Diseases; Genome-Wide Association Study; Genomics; Mite Infestations; Psoroptidae; Ecology, Evolution, Behavior and Systematics; Animal Science and Zoology; Genetics
Abstract :
[en] [en] BACKGROUND: Psoroptic mange, caused by Psoroptes ovis mites, is affecting Belgian Blue cattle's welfare and production potential. The Belgian Blue cattle-known for its high degree of muscling, low feed conversion ratio and high beef quality-is highly susceptible for this disease.
RESULTS: In this study, we phenotyped 1975 Belgian Blue cattle from more than 100 different groups on commercial beef farms for their psoroptic mange susceptibility. Substantial individual differences were observed within these management groups, with lesion extent differences up to ± 15%. Animal models showed that estimated heritabilities were low for lesion extent and severe lesion extent (0.07 and 0.09, respectively) and 0.12 for the number of mites. A genome wide association study for mange susceptibility revealed signals on BTA6, BTA11, BTA15 and BTA24. In these regions, candidate genes GBA3, RAG2, and TRAF6 were identified.
CONCLUSIONS: Despite the challenges in phenotyping for psoroptic mange due to the timing of screening, the continuous evolution of lesions and different management conditions, we successfully conducted a study on the genetic susceptibility to psoroptic mange in Belgian Blue cattle. Our results clearly indicate that psoroptic mange is under polygenic control and the underlying candidate genes should be studied more thoroughly. This is the first study providing candidate genes for this complex disease. These results are already valuable for Belgian Blue breeding, however, further research is needed to unravel the architecture of this disease and to identify causal mutations.
Disciplines :
Veterinary medicine & animal health Genetics & genetic processes Agriculture & agronomy
Author, co-author :
Meyermans, Roel ; Center for Animal Breeding and Genetics, Department of Biosystems, KU Leuven, 3001, Leuven, Belgium. roel.meyermans@kuleuven.be
Janssens, Steven; Center for Animal Breeding and Genetics, Department of Biosystems, KU Leuven, 3001, Leuven, Belgium
Coussé, Annelies; Center for Animal Breeding and Genetics, Department of Biosystems, KU Leuven, 3001, Leuven, Belgium
Tinel, Susanne; Center for Animal Breeding and Genetics, Department of Biosystems, KU Leuven, 3001, Leuven, Belgium
Gorssen, Wim; Center for Animal Breeding and Genetics, Department of Biosystems, KU Leuven, 3001, Leuven, Belgium
FOD Volksgezondheid - Federale Overheidsdienst Volksgezondheid - Veiligheid van de Voetselketen en Leefmilieu [BE] FWO - Fonds Wetenschappelijk Onderzoek Vlaanderen [BE] F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE] KU Leuven - Catholic University of Leuven [BE]
Funding text :
The research that yielded these results was partly funded by the Belgian Federal Public Service of Health, Food Chain Safety and Environment through contracts RT 11/5 PSOROVIS and RT 17/1 BOMANGE. This research is also funded by a SB PhD fellowship (1S37119N) [RM], a FR PhD fellowship (1104320N) [WG] of the Research Foundation Flanders (FWO) and an Internal Funds grant of KU Leuven (PDMT2/23/035) [RM]. [TD] and [CC] are senior research associate and research director from the Fonds de la Recherche Scientifique\u2014FNRS (F.R.S.-FNRS).
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