[en] Equine atypical myopathy (AM) is a severe rhabdomyolysis syndrome primarily caused by hypoglycin A (HGA) and methylenecyclopropylglycine protoxins. This study aimed to refine diagnostic and prognostic criteria for AM while exploring apparently healthy cograzers. Blood samples from 263 horses, including AM cases (n= 95), cograzers (n= 73), colic horses (n= 19), and controls (n= 76), were analyzed for HGA, its toxic metabolite, and acylcarnitines profile. Diseased horses exhibited alterations in acylcarnitines that strongly distinguished them from controls and colic horses. Regression analyses identified distinct acylcarnitines profiles among groups, with cograzers showing intermediate alterations. Age and gelding status emerged as protective factors against AM. Furthermore, serum acylcarnitines profiling was valuable in predicting AM survival, with isovaleryl-/2-methylbutyrylcarnitine (i.e., C5 acylcarnitine) showing promise as both a diagnostic and prognostic marker. Subclinical alterations in cograzers underscore a novel aspect: the presence of subclinical cases of AM.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Renaud, Benoît ; Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH)
Kruse, Caroline-J; Department of Functional Sciences, Faculty of Veterinary Medicine, Physiology and Sport Medicine, Fundamental and Applied Research for Animals & Health (FARAH), University of Liège, 4000 Liège 1 (Sart Tilman), Belgium. Electronic address: caroline.kruse@uliege.be
François, Anne-Christine ; Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH)
Cesarini, Carla; Equine Clinical Department, Faculty of Veterinary Medicine, Bât. B41, Sart Tilman, University of Liège, 4000 Liège, Belgium. Electronic address: ccesarini@uliege.be
van Loon, Gunther; Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, 9820 Ghent, Belgium. Electronic address: gunther.vanloon@ugent.be
Boemer, François ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale
LUIS, Géraldine ; Centre Hospitalier Universitaire de Liège - CHU > > Service de génétique
Gustin, Pascal ; Université de Liège - ULiège > Département des sciences fonctionnelles (DSF) > Pharmacologie, pharmacothérapie et toxicologie
Votion, Dominique ; Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH) > FARAH: Médecine vétérinaire comparée
Language :
English
Title :
Large-Scale Study of Blood Markers in Equine Atypical Myopathy Reveals Subclinical Poisoning and Advances in Diagnostic and Prognostic Criteria.
SPW Agriculture, Ressources naturelles et Environnement - Service Public de Wallonie. Agriculture, Ressources naturelles et Environnement ULiège FSR - Université de Liège. Fonds spécial pour la recherche
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