Humans; Aged; Male; Female; Middle Aged; Aging; Aged, 80 and over; Sleep, REM/physiology; Circadian Rhythm; Brain/diagnostic imaging; Brain/metabolism; Magnetic Resonance Imaging; Brain; Sleep, REM; Medicine (miscellaneous); Biochemistry, Genetics and Molecular Biology (all)
Abstract :
[en] Rapid eye movement sleep (REMS) is increasingly suggested as a discriminant sleep state for subtle signs of age-related neurodegeneration. While REMS expression is under strong circadian control and circadian dysregulation increases with age, the association between brain aging and circadian REMS regulation has not yet been assessed. Here, we measure the circadian amplitude of REMS through a 40-h in-lab multiple nap protocol in controlled laboratory conditions, and brain microstructural integrity with quantitative multi-parameter mapping (MPM) imaging in 86 older individuals. We show that reduced circadian REMS amplitude is related to lower magnetization transfer saturation (MTsat), longitudinal relaxation rate (R1) and effective transverse relaxation rate (R2*) values in several white matter regions mostly located around the lateral ventricles, and with lower R1 values in grey matter clusters encompassing the hippocampus, parahippocampus, thalamus and hypothalamus. Our results further highlight the importance of considering circadian regulation for understanding the association between sleep and brain structure in older individuals.
Disciplines :
Neurology
Author, co-author :
Deantoni, Michele ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Reyt, Mathilde; GIGA-CRC Human Imaging, University of Liège, Liège, Belgium ; Psychology and Neuroscience of Cognition Research Unit (PsyNCog), Faculty of Psychology and Educational Sciences, University of Liège, Liège, Belgium
Dourte, Marine ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
de Haan, Stella ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Lesoinne, Alexia ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Vandewalle, Gilles ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques
Phillips, Christophe ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Neuroimaging, data acquisition and processing
Berthomier, Christian; Physip, Paris, France
Maquet, Pierre ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Muto, Vincenzo ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging
Hammad, Grégory ; Université de Liège - ULiège > Département de Psychologie > Neuropsychologie de l'adulte ; Human Chronobiology and Sleep, University of Surrey, Guildford, England
Schmidt, Christina ; Université de Liège - ULiège > Département de Psychologie > Neuropsychologie de l'adulte
Baillet, Marion ; GIGA-CRC Human Imaging, University of Liège, Liège, Belgium. marion.baillet@uliege.be
We thank S. Laloux and E. Lambot, for their help in data acquisition and/or technical assistance, and Dr. E. Balteau for her help in MRI data processing. This study was supported by the Belgian Fund for Scientific Research (FNRS-PDR BIGSLEEP #35294033) and the European Research Council (ERC-Starting Grant COGNAP #GA757763). M.De., M.Do. S.dH., G.V., C.P., C.S. are supported by the FNRS-Belgium.
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