High precision blood lead radiogenic isotope signatures in a community exposed to Pb contaminated soils and implications for the current Pb exposure of the European population.
Petit, Jérôme C J; Mattielli, Nadine; De Jong, Jeroenet al.
2024 • In Science of the Total Environment, p. 174763
[en] Our study provides the most comprehensive dataset for high-precision radiogenic isotopes of lead (Pb) in blood for the western European population. It investigates their potential for elucidating the contribution of soil Pb to blood Pb using a human biomonitoring survey involving 81 adults and 4 children living in the urban area of Liège (Belgium). Soils in the area show moderate (median of 360 mg/kg) to high (95th percentile of 1000 mg/kg) Pb concentrations, due to former metal processing activities. Blood lead levels (BLL) measured in the study population are, on average, quantitatively consistent with a ~ 20 % increase due to the exposure to Pb from soils, as estimated by a single-compartment biokinetic model. Consistently, its isotopic composition does not represent an endmember that fully accounts for the variability of Blood lead isotope (BLI) compositions measured in the study population. While some individuals show more thorogenic BLI ratios (relatively more enriched in 208Pb), which could be consistent with a greater exposure to local soils and/or by their country of birth, the BLI data mostly follow a trend roughly parallel to the European Standard Lead Pollution (ESLP) line, within the European leaded gasoline field, even two decades after the withdrawal of this source. Differences in BLI are probably associated with factors related to the presence of Pb in dwellings (pipes, paint) and drinking water distribution system, suggesting that the anthropogenic Pb in use, relevant to human exposure, may contain ore components of different origins, including the Australian Pb ore signature.
Disciplines :
Earth sciences & physical geography
Author, co-author :
Petit, Jérôme C J; Institut Scientifique de Service Public, Rue du Chéra 200, 4000 Liège, Belgium. Electronic address: j.petit@issep.be
Mattielli, Nadine; Laboratoire G-TIME, Faculté des Sciences, Université Libre de Bruxelles, Av. F.D. Roosevelt 50 CP106/02 1050, Bruxelles, Belgium. Electronic address: nadine.mattielli@ulb.be
De Jong, Jeroen; Laboratoire G-TIME, Faculté des Sciences, Université Libre de Bruxelles, Av. F.D. Roosevelt 50 CP106/02 1050, Bruxelles, Belgium. Electronic address: johannes.jeroen.de.jong@ulb.be
Bouhoulle, Elodie; Institut Scientifique de Service Public, Rue du Chéra 200, 4000 Liège, Belgium. Electronic address: e.bouhoulle@issep.be
Debouge, Wendy; Laboratoire G-TIME, Faculté des Sciences, Université Libre de Bruxelles, Av. F.D. Roosevelt 50 CP106/02 1050, Bruxelles, Belgium. Electronic address: wendy.debouge@ulb.be
Maggi, Patrick ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique : aspects généraux ; FPS Health, Food Chain Safety and Environment, Ecotoxicology Unit from Service Plant protection and Fertilising products, 5/2 Avenue Galilée, B-1210 Brussels, Belgium. Electronic address: patrick.maggi@health.fgov.be
Hublet, Geneviève; Laboratoire G-TIME, Faculté des Sciences, Université Libre de Bruxelles, Av. F.D. Roosevelt 50 CP106/02 1050, Bruxelles, Belgium. Electronic address: genevieve.hublet@ulb.be
Fagel, Nathalie ; Université de Liège - ULiège > Département de géologie > Argiles, géochimie et environnements sédimentaires
Pirard, Catherine ; Université de Liège - ULiège > Département des sciences de la santé publique
Charlier, Corinne ; Université de Liège - ULiège > Département de pharmacie > Chimie toxicologique
Suzanne, Remy; Institut Scientifique de Service Public, Rue du Chéra, 200, 4000 Liège, Belgium. Electronic address: s.remy@issep.be
Language :
English
Title :
High precision blood lead radiogenic isotope signatures in a community exposed to Pb contaminated soils and implications for the current Pb exposure of the European population.
ANSES, Etude de l'alimentation totale française 2 (EAT 2) Tome 1 : Contaminants inorganiques, minéraux, polluants organiques persistants, mycotoxines, phyto-estrogènes. Available online at https://www.anses.fr/fr/system/files/PASER2006sa0361Ra1.pdf, 2011.
Becker, K., Schulz, C., Kaus, S., Seiwert, M., Seifert, B., German environmental survey 1998 (GerES III): environmental pollutants in the urine of the German population. Int. J. Hyg. Environ. Health 206:1 (2003), 15–24, 10.1078/1438-4639-00188.
Becker, F., Marcantonio, F., Datta, S., Wichterich, C., Cizmas, L., Surber, J., Kennedy, K., Bowles, E., Tracking the source of contaminant lead in children's blood. Environ. Res., 212, 2022, 113307, 10.1016/j.envres.2022.113307.
Bierkens, J., Smolders, R., Van Holderbeke, M., Cornelis, C., Predicting blood Lead levels from current and past environmental data in Europe. Sci. Total Environ. 409:23 (2011), 5101–5110, 10.1016/j.scitotenv.2011.08.034.
Buatier, M.D., Sobanska, S., Elsass, F., TEM-EDX investigation on Zn- and Pb-contaminated soils. Appl. Geochem. 16:9 (2001), 1165–1177, 10.1016/S0883-2927(01)00015-4.
Cao, S., Duan, X., Zhao, X., Wang, B., Ma, J., Fan, D., Sun, C., He, B., Wei, F., Jiang, G., Isotopic ratio based source apportionment of children's blood Lead around coking plant area. Environ. Int. 73 (2014), 158–166, 10.1016/j.envint.2014.07.015.
Doe, B.R., Rohrbough, R., Lead Isotope Data Bank: 3,458 Samples and Analyses Cited. 79–66. 1977, United States Department of the Interior– Geological Survey, 10.3133/ofr79661.
Ellam, R.M., The graphical presentation of lead isotope data for environmental source apportionment. Sci. Total Environ. 408:16 (2010), 3490–3492, 10.1016/j.scitotenv.2010.03.037.
Etchevers, A., Glorennec, P., Lucas, J.-P., Le Bot, B., Lecoffre, C., Le Tertre, A., Exposition au plomb des enfants en France : niveaux d'imprégnation et déterminants. Toxicol. Anal. Clin. 29:4 (2017), 483–495, 10.1016/j.toxac.2017.07.001.
European Food Safety Authority, Scientific opinion on lead in food. EFSA J., 8(4), 2010, 1570, 10.2903/j.efsa.2010.1570.
Falq, G., Zeghnoun, A., Pascal, M., Vernay, M., Le Strat, Y., Garnier, R., Olichon, D., Bretin, P., Castetbon, K., Fréry, N., Blood lead levels in the adult population living in France the French Nutrition and Health Survey (ENNS 2006–2007). Environ. Int. 37:3 (2011), 565–571, 10.1016/j.envint.2010.11.012.
Galer, S.J.G., Practical application of lead triple spiking for correction of instrumental mass discrimination. Mineral. Mag. 62A:1 (1998), 491–492, 10.1180/minmag.1998.62A.1.260.
Gulson, B., Mizon, K., Korsch, M., Taylor, A., Changes in the lead isotopic composition of blood, diet and air in Australia over a decade: globalization and implications for future isotopic studies. Environ. Res. 100:1 (2006), 130–138, 10.1016/j.envres.2005.03.006.
Gulson, B., Kamenov, G., Manton, W., Rabinowitz, M., Concerns about quadrupole ICP-MS lead isotopic data and interpretations in the environment and health fields. IJERPH, 15(4), 2018, 723, 10.3390/ijerph15040723.
Gwiazda, R.H., Smith, D.R., Lead isotopes as a supplementary tool in the routine evaluation of household lead hazards. Environ. Health Perspect., 108(11), 2000.
Haack, U.K., Heinrichs, H., Gutsche, F.H., Plessow, K., The isotopic composition of anthropogenic Pb in soil profiles of northern Germany: evidence for pollutant Pb from a continent-wide mixing system. Water Air Soil Pollut. 150 (2003), 113–134.
Hutse, V., Claeys, F., Mertens, K., Surveillance Épidémiologique de La Population Belge - Métaux Lourds et Oligo-Éléments Dans Le Sang. Bruxelles https://www.wiv-isp.be/Epidemio/epifr/envifr/D_2006_2505_37.pdf, 2005.
Kamenov, G.D., Gulson, B., The Pb isotopic record of historical to modern human lead exposure. Sci. Total Environ. 490 (2014), 861–870, 10.1016/j.scitotenv.2014.05.085.
Kamenov, G.D., Swaringen, B.F., Cornwell, D.A., McTigue, N.E., Roberts, S.M., Bonzongo, J.-C.J., High-precision Pb isotopes of drinking water lead pipes: implications for human exposure to industrial Pb in the United States. Sci. Total Environ., 871, 2023, 162067, 10.1016/j.scitotenv.2023.162067.
Komárek, M., Ettler, V., Chrastný, V., Mihaljevič, M., Lead isotopes in environmental sciences: a review. Environ. Int. 34:4 (2008), 562–577, 10.1016/j.envint.2007.10.005.
Laycock, A., Chenery, S., Marchant, E., Crabbe, H., Saei, A., Ruadze, E., Watts, M., Leonardi, G.S., Marczylo, T., The use of Pb isotope ratios to determine environmental sources of high blood Pb concentrations in children: a feasibility study in Georgia. IJERPH, 19(22), 2022, 15007, 10.3390/ijerph192215007.
Li, H.-B., Chen, K., Juhasz, A.L., Huang, L., Ma, L.Q., Childhood Lead exposure in an industrial town in China: coupling stable isotope ratios with bioaccessible lead. Environ. Sci. Technol. 49:8 (2015), 5080–5087, 10.1021/es5060622.
Maddaloni, M., Ballew, M., VanLeeuwen, P., Koporec, K., Khoury, G., Johnson, M., Zaragoza, L., Review of Adult Lead Models. Evaluation of Models for Assessing Human Health Risks Associated with lead Exposures at Non-Residential Areas of Superfund and Other Hazardous Waste Sites. OSWER #9285.7-46, 2001, US-EPA 85 pp.
Manton, W.I., Angle, C.R., Stanek Krogstrand, K.L., Origin of Lead in the United States diet. Environ. Sci. Technol. 39:22 (2005), 8995–9000, 10.1021/es051145e.
Mielke, H.W., Gonzales, C.R., Powell, E.T., Egendorf, S.P., Lead in air, soil, and blood: Pb poisoning in a changing world. IJERPH, 19(15), 2022, 9500, 10.3390/ijerph19159500.
Nisse, C., Tagne-Fotso, R., Howsam, M., Richeval, C., Labat, L., Leroyer, A., Blood and urinary levels of metals and metalloids in the general adult population of northern France: the IMEPOGE study, 2008–2010. Int. J. Hyg. Environ. Health 220:2 (2017), 341–363, 10.1016/j.ijheh.2016.09.020.
Oleko, A., Fillol, C., Balicco, A., Gane, J., Saoudi, A., Zeghnoun, A., Imprégnation de la population française par le plomb. Programme national de biosurveillance, Esteban 2014-2016. 2609-2174, 2020, Santé publique France 979-10-289-0615-3, 53.
Oulhote, Y., Le Bot, B., Poupon, J., Lucas, J.-P., Mandin, C., Etchevers, A., Zmirou-Navier, D., Glorennec, P., Identification of sources of Lead exposure in French children by lead isotope analysis: a cross-sectional study. Environ. Health, 10(1), 2011, 75, 10.1186/1476-069X-10-75.
Patel, M.M., Adrianne, H., Jones, R., Jarrett, J., Berner, J., Rubin, C.S., Use of lead isotope ratios to identify sources of Lead exposure in Alaska natives. Int. J. Circumpolar Health 67:2–3 (2008), 261–268, 10.3402/ijch.v67i2-3.18283.
Petit, D., Véron, A., Flament, P., Deboudt, K., Poirier, A., Review of pollutant lead decline in urban air and human blood: a case study from northwestern Europe. Comptes Rendus. Géoscience 347:5–6 (2015), 247–256, 10.1016/j.crte.2015.02.004.
Petit, J.C.J., Peeters, M., Remy, S., Sustainable health-based soil standards for arsenic using epidemiological data and toxicokinetic/probabilistic modelling. Environ. Geochem. Health 44:11 (2022), 3853–3861, 10.1007/s10653-021-01143-2.
Petit, J.C.J., Maggi, P., Pirard, C., Charlier, C., Ruttens, A., Liénard, A., Colinet, G., Remy, S., Human biomonitoring survey (Pb, Cd, As, Cu, Zn, Mo) for urban gardeners exposed to metal contaminated soils. Environ. Pollut., 312, 2022, 120028, 10.1016/j.envpol.2022.120028.
Resongles, E., Dietze, V., Green, D.C., Harrison, R.M., Ochoa-Gonzalez, R., Tremper, A.H., Weiss, D.J., Strong evidence for the continued contribution of Lead deposited during the 20th century to the atmospheric environment in London of today. Proc. Natl. Acad. Sci. USA, 118(26), 2021, e2102791118, 10.1073/pnas.2102791118.
Retzmann, A., Zimmermann, T., Pröfrock, D., Prohaska, T., Irrgeher, J., A fully automated simultaneous single-stage separation of Sr, Pb, and Nd using DGA resin for the isotopic analysis of marine sediments. Anal. Bioanal. Chem. 409:23 (2017), 5463–5480, 10.1007/s00216-017-0468-6.
Sangster, D.F., Outridge, P.M., Davis, W.J., Stable Lead Isotope Characteristics of Lead Ore Deposits of Environmental Significance. 8, 2000.
Schulz, C., Conrad, A., Becker, K., Kolossa-Gehring, M., Seiwert, M., Seifert, B., Twenty years of the German Environmental Survey (GerES): human biomonitoring – temporal and spatial (West Germany/East Germany) differences in population exposure. Int. J. Hyg. Environ. Health 210:3–4 (2007), 271–297, 10.1016/j.ijheh.2007.01.034.
Shotyk, W., Weiss, D., Appleby, P.G., Cheburkin, A.K., Gloor, R.F.M., Kramers, J.D., Reese, S., Van Der Knaap, W.O., null., History of atmospheric lead deposition since 12,370 (14)C Yr BP from a Peat Bog, Jura Mountains, Switzerland. Science 281:5383 (1998), 1635–1640, 10.1126/science.281.5383.1635.
Smolders, R., Alimonti, A., Cerna, M., Den Hond, E., Kristiansen, J., Palkovicova, L., Ranft, U., Seldén, A.I., Telišman, S., Schoeters, G., Availability and comparability of human biomonitoring data across Europe: a case-study on blood-lead levels. Sci. Total Environ. 408:6 (2010), 1437–1445, 10.1016/j.scitotenv.2009.11.025.
Sonke, J.E., Hoogewerff, J.A., Van Der Laan, S.R., Vangronsveld, J., A chemical and mineralogical reconstruction of Zn-smelter emissions in the Kempen region (Belgium), based on organic pool sediment cores. Sci. Total Environ. 292:1–2 (2002), 101–119, 10.1016/S0048-9697(02)00033-5.
Sonke, J., Sivry, Y., Viers, J., Freydier, R., Dejonghe, L., Andre, L., Aggarwal, J., Fontan, F., Dupre, B., Historical variations in the isotopic composition of atmospheric zinc deposition from a zinc smelter. Chem. Geol. 252:3–4 (2008), 145–157, 10.1016/j.chemgeo.2008.02.006.
Sy, M., Eleftheriadou, D., Jung, C., Lindtner, O., Karakitsios, S., Sarigiannis, D., Weber, T., Kolossa-Gehring, M., Greiner, M., Assessment of the long-term exposure to lead in four European countries using PBPK modeling. Expo. Health 16:1 (2024), 21–39, 10.1007/s12403-023-00535-2.
U.S. Environmental Protection Agency, Update for Chapter 5 of the Exposure Factors Handbook - Soil and Dust Ingestion. EPA/600/R-17/384F https://www.epa.gov/sites/default/files/2018-01/documents/efh-chapter05_2017.pdf, 2017.
Vanderstraeten, A., Bonneville, S., Gili, S., De Jong, J., Debouge, W., Claeys, P., Mattielli, N., First multi-isotopic (Pb-Nd-Sr-Zn-Cu-Fe) characterisation of dust reference materials (ATD and BCR-723): a multi-column chromatographic method optimised to trace mineral and anthropogenic dust sources. Geostand. Geoanal. Res. 44:2 (2020), 307–329, 10.1111/ggr.12320.
Véron, A., Flament, P., Bertho, M.L., Alleman, L., Flegal, R., Hamelin, B., Isotopic evidence of pollutant Lead sources in northwestern France. Atmos. Environ. 33:20 (1999), 3377–3388, 10.1016/S1352-2310(98)00376-8.
Vodyanitskii, Yu.N., Arsenic, lead, and zinc compounds in contaminated soils according to EXAFS spectroscopic data: a review. Eurasian Soil Sc. 39:6 (2006), 611–621, 10.1134/S1064229306060056.
Weis, D., Kieffer, B., Maerschalk, C., Barling, J., de Jong, J., Williams, G.A., Hanano, D., Pretorius, W., Mattielli, N., Scoates, J.S., Goolaerts, A., Friedman, R.M., Mahoney, J.B., High-precision isotopic characterization of USGS reference materials by TIMS and MC-ICP-MS. Geochem. Geophys. Geosyst., 7(8), 2006, 10.1029/2006GC001283.
Weiss, D., Shotyk, W., Kempf, O., Archives of atmospheric lead pollution. Naturwissenschaften 86:6 (1999), 262–275, 10.1007/s001140050612.