Waked, Anthony ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine
Crabbé, Mélissa; SCK CEN - Belgian Nuclear Research Centre [BE]
Neirinckx, Virginie ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques ; Université de Liège - ULiège > GIGA > GIGA Neurosciences
Rodriguez Pérez, Sunay; SCK CEN - Belgian Nuclear Research Centre [BE]
Wellens, Jasmien; SCK CEN - Belgian Nuclear Research Centre [BE]
Rogister, Bernard ; Université de Liège - ULiège > GIGA > GIGA Neurosciences - Nervous system disorders and therapy
Benotmane, Abderrafi; SCK CEN - Belgian Nuclear Research Centre [BE]
Vermeulen, Koen; SCK CEN - Belgian Nuclear Research Centre [BE]
Language :
English
Title :
Preclinical evaluation of CXCR4 peptides for targeted radionuclide therapy in glioblastoma
A. Aerts U. Eberlein S. Holm R. Hustinx M. Konijnenberg L. Strigari et al. EANM position paper on the role of radiobiology in nuclear medicine Eur J Nucl Med Mol Imaging 2021 48 11 3365 77 33912987 8440244
L. Alhaddad R. Chuprov-Netochin M. Pustovalova A.N. Osipov S. Leonov Polyploid/Multinucleated giant and slow-Cycling Cancer Cell Enrichment in response to X-ray irradiation of human Glioblastoma Multiforme Cells Differing in Radioresistance and TP53/PTEN status Int J Mol Sci 2023 24 2 1228 1:CAS:528:DC%2BB3sXitFaltrs%3D 36674747 9865596
Birzu C, French P, Caccese M, Cerretti G, Idbaih A, Zagonel V, Lombardi G. Recurrent glioblastoma: from Molecular Landscape to New Treatment perspectives. Cancers (Basel). 2020;13(1).
J. Bolcaen J. Kleynhans S. Nair J. Verhoeven I. Goethals M. Sathekge et al. A perspective on the radiopharmaceutical requirements for imaging and therapy of glioblastoma Theranostics 2021 11 16 7911 47 1:CAS:528:DC%2BB3MXitFGnu7rM 34335972 8315062
W.E. Bolch K.F. Eckerman G. Sgouros S.R. Thomas MIRD pamphlet 21: a generalized schema for radiopharmaceutical dosimetry–standardization of nomenclature J Nucl Med 2009 50 3 477 84 1:CAS:528:DC%2BD1MXktVyns7k%3D 19258258
B.P. Burke C.S. Miranda R.E. Lee I. Renard S. Nigam G.S. Clemente et al. Cu-64 PET imaging of the CXCR4 chemokine receptor using a cross-bridged cyclam bis-tetraazamacrocyclic antagonist J Nucl Med 2020 61 1 123 8 1:CAS:528:DC%2BB3cXhslSku77E 31201250 9374041
S.U. Dalm J. Nonnekens G.N. Doeswijk G. Blois Ed M.W. DCv, Konijnenberg M. Jong Comparison of the therapeutic response to treatment with a 177 Lu-Labeled somatostatin receptor agonist and antagonist in preclinical models J Nucl Med 2016 57 2 260 5 1:CAS:528:DC%2BC28XitFSktr%2FN 26514177
S.J. DeMarco H. Henze A. Lederer K. Moehle R. Mukherjee B. Romagnoli et al. Discovery of novel, highly potent and selective β-hairpin mimetic CXCR4 inhibitors with excellent anti-HIV activity and pharmacokinetic profiles Bioorg Med Chem 2006 14 24 8396 404 1:CAS:528:DC%2BD28XhtFOjt7rM 17010618
A. Drenckhan N. Kurschat T. Dohrmann N. Raabe A.M. Koenig U. Reichelt et al. Effective inhibition of metastases and primary tumor growth with CTCE-9908 in esophageal cancer J Surg Res 2013 182 2 250 6 1:CAS:528:DC%2BC38XhsF2hsLvN 23117118
I. Dupin P. Henrot E. Maurat R. Abohalaka S. Chaigne D.E. Hamrani et al. Blocking CXCR4 improves pulmonary and cardiac outcomes in a mouse model of early COPD Eur Respir J 2023 62 suppl 67 OA4243
A. Faber C. Roderburg F. Wein R. Saffrich A. Seckinger K. Horsch et al. The many facets of SDF-1alpha, CXCR4 agonists and antagonists on hematopoietic progenitor cells J Biomed Biotechnol 2007 2007 3 26065 17541466 1874670
N. Goffart J. Kroonen E. Di Valentin M. Dedobbeleer A. Denne P. Martinive B. Rogister Adult mouse subventricular zones stimulate glioblastoma stem cells specific invasion through CXCL12/CXCR4 signaling Neuro Oncol 2015 17 1 81 94 1:CAS:528:DC%2BC28XitFSisrzE 25085362
N. Goffart A. Lombard F. Lallemand J. Kroonen J. Nassen E. Di Valentin et al. CXCL12 mediates glioblastoma resistance to radiotherapy in the subventricular zone Neuro Oncol 2017 19 1 66 77 1:CAS:528:DC%2BC1cXitFSntr7L 27370398
G.L. Gravina A. Mancini P. Muzi L. Ventura L. Biordi E. Ricevuto et al. CXCR4 pharmacogical inhibition reduces bone and soft tissue metastatic burden by affecting tumor growth and tumorigenic potential in prostate cancer preclinical models Prostate 2015 75 12 1227 46 1:CAS:528:DC%2BC2MXht1GkurrE 26073897
H. Hänscheid A. Schirbel P. Hartrampf S. Kraus R.A. Werner H. Einsele et al. Biokinetics and dosimetry of 177Lu-Pentixather J Nucl Med 2022 63 5 754 60 34413147
U. Hennrich M. Eder [177Lu]Lu-PSMA-617 (PluvictoTM): the first FDA-Approved Radiotherapeutical for treatment of prostate Cancer Pharmaceuticals 2022 15 10 1292 1:CAS:528:DC%2BB38Xisl2msLrL 36297404 9608311
U. Hennrich K. Kopka Lutathera® The first FDA- and EMA-Approved Radiopharmaceutical for peptide receptor Radionuclide Therapy Pharmaceuticals 2019 12 3 114 1:CAS:528:DC%2BB3cXot1Ojt7w%3D 31362406 6789871
E.H. Huang B. Singh M. Cristofanilli J. Gelovani C. Wei L. Vincent et al. A CXCR4 antagonist CTCE-9908 inhibits primary tumor growth and metastasis of breast cancer J Surg Res 2009 155 2 231 6 1:CAS:528:DC%2BD1MXovF2ru7c%3D 19482312
Jacobson O, Weiss ID, Kiesewetter DO, Farber JM, Chen X. PET of Tumor CXCR4 Expression with 4-18F-T140. J Clin Med. 2010;51(11):1796–1804.
S.M. Jacobs P. Wesseling B. de Keizer N. Tolboom F.F.T. Ververs G.C. Krijger et al. CXCR4 expression in glioblastoma tissue and the potential for PET imaging and treatment with [(68)Ga]Ga-Pentixafor /[(177)Lu]Lu-Pentixather Eur J Nucl Med Mol Imaging 2022 49 2 481 91 1:CAS:528:DC%2BB3MXmsVChurw%3D 33550492
D.R. Johnson B.P. O’Neill Glioblastoma survival in the United States before and during the temozolomide era J Neurooncol 2012 107 2 359 64 1:CAS:528:DC%2BC38Xjs1Shtrk%3D 22045118
T. Kazda A. Dziacky P. Burkon P. Pospisil M. Slavik Z. Rehak et al. Radiotherapy of Glioblastoma 15 years after the Landmark Stupp’s trial: more controversies than standards? Radiol Oncol 2018 52 2 121 8 30018514 6043880
A.B. Khan S. Lee A.S. Harmanci R. Patel K. Latha Y. Yang et al. CXCR4 expression is associated with proneural-to-mesenchymal transition in glioblastoma Int J Cancer 2023 152 4 713 24 1:CAS:528:DC%2BB38XislKqu73I 36250346
Khazaei Monfared Y, Heidari P, Klempner SJ, Mahmood U, Parikh AR, Hong TS et al. DNA damage by Radiopharmaceuticals and mechanisms of Cellular Repair. Pharmaceutics. 2023;15(12).
W.G. Lesniak E. Sikorska H. Shallal B. Behnam Azad A. Lisok M. Pullambhatla et al. Structural characterization and in vivo evaluation of β-Hairpin peptidomimetics as specific CXCR4 imaging agents Mol Pharm 2015 12 3 941 53 1:CAS:528:DC%2BC2MXovFGgsg%3D%3D 25590535 4612581
W.G. Lesniak E. Sikorska H. Shallal B. Behnam Azad A. Lisok M. Pullambhatla et al. Structural characterization and in vivo evaluation of beta-hairpin peptidomimetics as specific CXCR4 imaging agents Mol Pharm 2015 12 3 941 53 1:CAS:528:DC%2BC2MXovFGgsg%3D%3D 25590535 4612581
F. Li X. Xu J. Geng X. Wan H. Dai The autocrine CXCR4/CXCL12 axis contributes to lung fibrosis through modulation of lung fibroblast activity Exp Ther Med 2020 19 3 1844 54 1:CAS:528:DC%2BB3cXhslCiu7vF 32104240 7027131
G. Liu X. Yuan Z. Zeng P. Tunici H. Ng I.R. Abdulkadir et al. Analysis of gene expression and chemoresistance of CD133 + cancer stem cells in glioblastoma Mol Cancer 2006 5 1 67 17140455 1697823
A. Lombard M. Digregorio C. Delcamp B. Rogister C. Piette N. Coppieters The Subventricular Zone, a Hideout for Adult and Pediatric High-Grade Glioma Stem cells Front Oncol 2020 10 614930 33575218
K. Luyten T. Van Loy C. Cawthorne C.M. Deroose D. Schols G. Bormans F. Cleeren D-Peptide-based probe for CXCR4-Targeted Molecular Imaging and Radionuclide Therapy Pharmaceutics 2021 13 10 1619 1:CAS:528:DC%2BB3MXivVart7zE 34683912 8537445
X. Ma F. Shang W. Zhu Q. Lin CXCR4 expression varies significantly among different subtypes of glioblastoma multiforme (GBM) and its low expression or hypermethylation might predict favorable overall survival Expert Rev Neurother 2017 17 9 941 6 1:CAS:528:DC%2BC2sXhtFKhsLvP 28685624
Z.S. Morris A.Z. Wang S.J. Knox The Radiobiology of Radiopharmaceuticals Semin Radiat Oncol 2021 31 1 20 7 33246632 7990047
Y. Nie J. Waite F. Brewer M.J. Sunshine D.R. Littman Y.R. Zou The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity J Exp Med 2004 200 9 1145 56 1:CAS:528:DC%2BD2cXpsFCgs7k%3D 15520246 2211858
E.A.M. Ruigrok N. van Vliet S.U. Dalm E. de Blois D.C. van Gent J. Haeck et al. Extensive preclinical evaluation of lutetium-177-labeled PSMA-specific tracers for prostate cancer radionuclide therapy Eur J Nucl Med Mol Imaging 2021 48 5 1339 50 1:CAS:528:DC%2BB3cXit1WmsbzJ 33094433
J. Sanchez Gil M. Dubois V. Neirinckx A. Lombard N. Coppieters P. D’Arrigo et al. Nanobody-based retargeting of an oncolytic herpesvirus for eliminating CXCR4 + GBM cells: a proof of principle Mol Therapy - Oncolytics 2022 26 35 48 1:CAS:528:DC%2BB38XitFSls7bJ
Sarkaria JN, Hu LS, Parney IF, Pafundi DH, Brinkmann DH, Laack NN, et al. Is the blood-brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data. Neuro Oncol. 2018;20(2):184–191.
M.G. Stabin J.A. Siegel RADAR dose Estimate Report: a compendium of Radiopharmaceutical Dose estimates based on OLINDA/EXM Version 2.0 J Nucl Med 2018 59 1 154 60 28887400
A. Taghian H. Suit F. Pardo D. Gioioso K. Tomkinson W. DuBois L. Gerweck In vitro intrinsic radiation sensitivity of glioblastoma multiforme Int J Radiation Oncology*Biology*Physics 1992 23 1 55 62 1:STN:280:DyaK383kt1Wktw%3D%3D
Tolboom N, Verger A, Albert NL, Fraioli F, Guedj E, Traub-Weidinger T et al. Theranostics in Neurooncology: Heading Toward New Horizons. Journal of Nuclear Medicine. 2023:jnumed.123.266205.
T. Vag C. Gerngross P. Herhaus M. Eiber K. Philipp-Abbrederis F.P. Graner et al. First experience with chemokine receptor CXCR4-Targeted PET imaging of patients with solid cancers J Nucl Med 2016 57 5 741 6 1:CAS:528:DC%2BC2sXhslaktLjO 26769866
A. Waheed B. Singh A. Watts H. Kaur H. Singh K. Dhingra et al. 68 Ga-Pentixafor PET/CT for in vivo imaging of CXCR4 receptors in Glioma demonstrating a potential for Response Assessment to Radiochemotherapy: preliminary results Clin Nucl Med 2024 49 4 e141 8 38350065
S. Witthayanuwat M. Pesee C. Supaadirek N. Supakalin K. Thamronganantasakul S. Krusun Survival analysis of Glioblastoma Multiforme Asian Pac J Cancer Prev 2018 19 9 2613 7 1:CAS:528:DC%2BC1MXntVOqtr8%3D 30256068 6249474
Y. Xie T. Bergström Y. Jiang P. Johansson V.D. Marinescu N. Lindberg et al. The Human Glioblastoma Cell Culture Resource: validated cell models representing all Molecular subtypes EBioMedicine 2015 2 10 1351 63 26629530 4634360
Y. Xu S. Duggineni S. Espitia D.D. Richman J. An Z. Huang A synthetic bivalent ligand of CXCR4 inhibits HIV infection Biochem Biophys Res Commun 2013 435 4 646 50 1:CAS:528:DC%2BC3sXos12lsbg%3D 23688427 3752463
Z. Zhang X. Feng Z. Deng J. Cheng Y. Wang M. Zhao et al. Irradiation-induced polyploid giant cancer cells are involved in tumor cell repopulation via neosis Mol Oncol 2021 15 8 2219 34 1:CAS:528:DC%2BB38XislagurfF 33523579 8334289
Y. Zhao T. Lu Y. Song Y. Wen Z. Deng J. Fan et al. Cancer cells enter an adaptive persistence to survive Radiotherapy and Repopulate Tumor Adv Sci 2023 10 8 2204177 1:CAS:528:DC%2BB3sXhs1ahu7Y%3D
