Enhanced identification of endocrine disruptors through integration of science-based regulatory practices and innovative methodologies: The MERLON Project.
adverse outcome pathways; endocrine disruption; gender; new approach methodologies; regulatory toxicology; reproduction; sexual development; systems biology
Abstract :
[en] The prevalence of hormone-related health issues caused by exposure to endocrine disrupting chemicals (EDCs) is a significant, and increasing, societal challenge. Declining fertility rates together with rising incidence rates of reproductive disorders and other endocrine-related diseases underscores the urgency in taking more action. Addressing the growing threat of EDCs in our environment demands robust and reliable test methods to assess a broad variety of endpoints relevant for endocrine disruption. EDCs also require effective regulatory frameworks, especially as the current move towards greater reliance on non-animal methods in chemical testing puts to test the current paradigm for EDC identification, which requires that an adverse effect is observed in an intact organism. Although great advances have been made in the field of predictive toxicology, disruption to the endocrine system and subsequent adverse health effects may prove particularly difficult to predict without traditional animal models. The MERLON project seeks to expedite progress by integrating multispecies molecular research, new approach methodologies (NAMs), human clinical epidemiology, and systems biology to furnish mechanistic insights and explore ways forward for NAM-based identification of EDCs. The focus is on sexual development and function, from foetal sex differentiation of the reproductive system through mini-puberty and puberty to sexual maturity. The project aims are geared towards closing existing knowledge gaps in understanding the effects of EDCs on human health to ultimately support effective regulation of EDCs in the European Union and beyond.
Disciplines :
Pediatrics
Author, co-author :
Svingen, Terje ; National Food Institute, Technical University of Denmark, Kgs. Lyngby, Region Hovedstaden, 2800, Denmark
Andersson, Anna-Maria; Department of Growth and Reproduction, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark ; International Center for Research and Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark
Angelova, Julianna; Health and Environment Alliance (HEAL), Brussels, Belgium
Axelstad, Marta; National Food Institute, Technical University of Denmark, Kgs. Lyngby, Region Hovedstaden, 2800, Denmark
Bakker, Julie ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau
Baumann, Lisa; Environmental Health and Toxicology, Amsterdam Institute for Life and Environment, Vrije Universiteit Amsterdam, Amsterdam, North Holland, 2800, The Netherlands
Beronius, Anna; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 17177, Sweden
Bouftas, Nora ; Environmental Health and Toxicology, Amsterdam Institute for Life and Environment, Vrije Universiteit Amsterdam, Amsterdam, North Holland, 2800, The Netherlands
Chalmel, Frederic; Univ Rennes, Inserm, Irset (Institut de recherche en santé, environnement et travail), Rennes, F-25000, France
Christiansen, Sofie ; National Food Institute, Technical University of Denmark, Kgs. Lyngby, Region Hovedstaden, 2800, Denmark
Cornil, Charlotte ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques
Damdimopoulou, Pauliina; Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Huddinge, 14186, Sweden ; Department of Gynecology and Reproductive Medicine, Karolinska Institutet, Huddinge, 14186, Sweden
Deepika, Deepika ; IISPV, Departament d' Enginyeria Quimica, Universitat Rovira i Virgili, Tarragona, Catalonia, 43007, Spain
Dollé, Martijn E T; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
Draskau, Monica Kam ; National Food Institute, Technical University of Denmark, Kgs. Lyngby, Region Hovedstaden, 2800, Denmark
Fischer, Margit Bistrup; Department of Growth and Reproduction, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark ; International Center for Research and Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark
Hagen, Casper P; Department of Growth and Reproduction, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark ; International Center for Research and Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark
Hessel, Ellen; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
Holmer, Marie Louise; National Food Institute, Technical University of Denmark, Kgs. Lyngby, Region Hovedstaden, 2800, Denmark
Hughes, Samantha ; Environmental Health and Toxicology, Amsterdam Institute for Life and Environment, Vrije Universiteit Amsterdam, Amsterdam, North Holland, 2800, The Netherlands
Jensen, Genon; Health and Environment Alliance (HEAL), Brussels, Belgium
Johansson, Hanna Katarina Lilith; National Food Institute, Technical University of Denmark, Kgs. Lyngby, Region Hovedstaden, 2800, Denmark
Juul, Anders ; Department of Growth and Reproduction, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark ; International Center for Research and Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark ; Department of Clinical Medicine, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark
Kumar, Vikas; IISPV, Departament d' Enginyeria Quimica, Universitat Rovira i Virgili, Tarragona, Catalonia, 43007, Spain
Kumar, Saurav ; IISPV, Departament d' Enginyeria Quimica, Universitat Rovira i Virgili, Tarragona, Catalonia, 43007, Spain
Lardenois, Aurélie; Univ Rennes, Inserm, Irset (Institut de recherche en santé, environnement et travail), Rennes, F-25000, France
Main, Katharina M; Department of Growth and Reproduction, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark ; International Center for Research and Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark ; Department of Clinical Medicine, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark
Mazaud-Guittot, Severine; Univ Rennes, Inserm, Irset (Institut de recherche en santé, environnement et travail), Rennes, F-25000, France
Moe, S Jannicke ; Norwegian Institute for Water Research (NIVA), Oslo, 0579, Norway
Mola, Gylli; Department of Growth and Reproduction, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark ; International Center for Research and Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark
Parent, Anne-Simone ; Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie
Pineda, Rafael; Department of Cell Biology, Physiology and Immunology / IMIBIC., University of Cordoba, Cordoba, 14012, Spain
Rolland, Antoine; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 17177, Sweden
Rosenmai, Anna Kjerstine; National Food Institute, Technical University of Denmark, Kgs. Lyngby, Region Hovedstaden, 2800, Denmark
Song, You ; Norwegian Institute for Water Research (NIVA), Oslo, 0579, Norway
Suglia, Antonio; Univ Rennes, Inserm, Irset (Institut de recherche en santé, environnement et travail), Rennes, F-25000, France
Tena-Sempere, Manuel; Department of Cell Biology, Physiology and Immunology / IMIBIC., University of Cordoba, Cordoba, 14012, Spain
Wehrli, Lydia ; Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Huddinge, 14186, Sweden ; Department of Gynecology and Reproductive Medicine, Karolinska Institutet, Huddinge, 14186, Sweden
Zilliacus, Johanna; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 17177, Sweden
van Duursen, Majorie; Environmental Health and Toxicology, Amsterdam Institute for Life and Environment, Vrije Universiteit Amsterdam, Amsterdam, North Holland, 2800, The Netherlands
Enhanced identification of endocrine disruptors through integration of science-based regulatory practices and innovative methodologies: The MERLON Project.
HE - 101137411 - MERLON - Merging scientific Evidence with Regulatory practices and Leveraging identification Of endocrine disruptors using New approach methodologies
Funders :
EU - European Union
Funding text :
HORIZON EUROPE Global Challenges and European Industrial Competitiveness
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