[en] Objectives: To evaluate some confounding factors that influence the concentrations of S100 calcium binding protein B (S100B), glial fibrillary acidic protein (GFAP), and ubiquitin carboxyl-terminal hydrolase L-1 (UCH-L1) in older individuals. Indeed, recent guidelines have proposed the combined use of S100B and the “GFAP-UCH-L1” mTBI test to rule out mild traumatic brain injuries (mTBI). As older adults are the most at risk of mTBI, it is particularly important to understand the confounding factors of those mTBI rule-out biomarkers in aging population. Methods: The protein S100B and the “GFAP and UCH-L1” mTBI test were measured using Liaison XL (Diasorin) and Alinity I (Abbott), respectively, in 330 and 341 individuals with non-suspected mTBI from the SarcoPhAge cohort. Results: S100B, GFAP and UCH-L1 were all significantly correlated with renal function whereas alcohol consumption, Geriatric Depression Score (GDS), smoking habits and anticoagulant intake were not associated with any of these three biomarkers. Body mass index (BMI) and age were associated with GFAP and UCH-L1 expression while sex and mini-mental state examination (MMSE) were only associated with GFAP. According to the manufacturer’s cut-offs for mTBI rule-out, only 5.5 % of participants were positive for S100B whereas 66.9 % were positive for the “GFAP-UCH-L1” mTBI test. All positive “GFAP-UCH-L1” mTBI tests were GFAP+/UCH-L1-. Among individuals with cystatin C>1.55 mg/L, 25 % were positive for S100B while 90 % were positive for the mTBI test. Conclusions: Our data show that confounding factors have different impacts on the positivity rate of the “GFAP-UCH-L1” mTBI test compared to S100B.
Disciplines :
Public health, health care sciences & services
Author, co-author :
Calluy, Emma; Clinical Chemistry Department, CHU de Liège, University of Liège, Liège, Belgium
Beaudart, Charlotte ; Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie générale
Alokail, Majed S.; Protein Research Chair, Biochemistry Department, College of Science, KSU, Riyadh, Saudi Arabia
Al-Daghri, Nasser ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé ; Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, KSU, Riyadh, Saudi Arabia
Bruyère, Olivier ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Reginster, Jean-Yves ; Université de Liège - ULiège > Département des sciences de la santé publique
Cavalier, Etienne ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Ladang, Aurélie ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Language :
English
Title :
Confounding factors of the expression of mTBI biomarkers, S100B, GFAP and UCH-L1 in an aging population
This work was supported by the Distinguished Scientist Fellowship Program (DSFP) of the King Saud University, Riyadh, Kingdom of Saudi Arabia.Research funding: This study was supported by clinical chemistry department and University of Li\u00E8ge as well as by the Distinguished Scientist Fellowship Program from the King Saud University.
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