The effect of vincamine on the regional cerebral blood flow in man

The cerebral hemodynamic action of vincamine is measured in 17 patients with primary or secondary cerebral circulation disorders, by use of the multigregional 153 Xe clearance technique. The statistical analysis of the result justifies the grouping of all the cases and the distinction between reference, ischemic and hyperemic zones by determinating for each subject a range of + or - 15% of his own mean regional cerebral flow, the drug, in a single injection in the internal carotid artery, shows a significant beneficial hemodynamic effect on the ischemic region of the brain. No steal phenomenon is recorded in the middle cerebral artery territory. The action of the drug leads to a decrease to an equalization of the hemodynamic resistances of the cerebral vascular bed