[en] The mammalian genome contains hundreds if not thousands of zinc finger protein (Zfp) genes. While the function of most of these genes remains to be determined, it is clear that a few of them play important roles in gene regulation and development. In studies described here, we have used an interspecific mouse backcross mapping panel to determine the chromosomal location of 15 KRAB-containing zinc finger loci. These loci map to nine different mouse autosomes and the X Chromosome (Chr). Two Chrs, 7 and 9, contain cosegregating pairs of KRAB-containing Zfp genes, indicating that the KRAB-containing Zfp genes have evolved through processes involving regional as well as genome-wide duplication events.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Marine, J. C.; Université de Liège - ULiège
Gilbert, D. J.; NCI-Frederick Cancer Research and Development Center
Bellefroid, Eric J.; Georg-August Universität Göttingen
Martial, Joseph ; Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Ihle, J. N.; St. Jude Children’s Research Hospital
Copeland, N. G.; NCI-Frederick Cancer Research and Development Center
Jenkins, N. A.; NCI-Frederick Cancer Research and Development Center
Language :
English
Title :
Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci
Publication date :
1996
Journal title :
Mammalian Genome
ISSN :
0938-8990
eISSN :
1432-1777
Publisher :
Springer Verlag, New York, United States - New York
Ashworth, A., Denny, P. (1991). Zinc finger protein genes in the mouse genome. Mamm. Genome 1, 196-200.
Bellefroid, E.J., Poncelet, D.A., Lecocq, P.J., Revelant, O., Martial, J.A. (1991). The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. Proc. Natl. Acad. Sci. USA 88, 3608-3616.
Bellefroid, E.J., Marine, J.-C., Ried, T., Lecocq, P.J., Riviere, M., Amemiya, C., Poncelet, D.A., Coulie, P.G., de Jong, P., Szpirer, C., Ward, D.C., Martial J.A. (1993). Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. EMBO J. 12, 1363-1374.
Bellefroid, E.J., Marine, J.-C., Matera, G.A., Bourguignon, C., Desai, T., Healey, K.C., Bray-Ward, P., Martial, J.A., Ihle, J.N., Ward, D.C. (1995). Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of Anthropoidea. Proc. Natl. Acad. Sci. USA 92, 10757-10761.
Brannan, C.I., Gilbert, D.J., Ceci, J.D., Matsuda, Y., Chapman, V.M., Mercer, J.A., Eisen, H., Johnston, L.A., Copeland, N.G., Jenkins, N.A. (1992). An interspecific linkage map of mouse chromosome 15 positioned with respect to the centromere. Genomics 13, 1075-1081.
Budarf, M., Huebner, K., Emanuel, B., Croce, C.M., Copeland, N.G., Jenkins N.A., D'Andrea, A.D. (1990). Assignment of the erythropoietin receptor (EPOR) gene to mouse chromosome 9 and human chromosome 19. Genomics 8, 575-578.
Chowdhury, K., Dietrich, S., Balling, R., Guénet, J.-L., Gruss, P. (1989). Structure, expression and chromosomal localization of Zfp-1, a murine zinc finger protein gene. Nucleic Acids Res. 17, 10427-10438.
Copeland, N.G., Jenkins, N.A. (1991). Development and applications of a molecular genetic linkage map of the mouse genome. Trends Genet. 7, 113-118.
Copeland, N.G., Gilbert, D.J., Chrétien, M., Seidah, N.G., Jenkins, N.A. (1992). Regional localization of three convertases, PCI (Nec-1), PC2 (Nec-2), and furin (Fur), on mouse chromosomes. Genomics 13, 1356-1358.
Cross, J.C., Flannery, M.L., Blanar, M.A., Steingrimsson, E., Jenkins, N.A., Copeland, N.G., Rutter, W.J., Werb, Z. (1995). Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development. Development 121, 2513-2523.
Crossley, P.H., Little, P.F.R. (1991). A cluster of related zinc finger protein genes is deleted in the mouse embryonic lethal mutation tw18. Proc. Natl. Acad. Sci. USA 88, 7923-7927.
Dickinson, M.E., Kobrin, M.S., Silan, C.M., Kingsley, D.M., Justice, M.J., Miller, D.A., Ceci, J.D., Lock, L.F., Lee, A., Buchberg, A.M., Siracusa, L.D., Lyons, K.M., Derynck, R., Hogan, B.L.M., Copeland, N.G., Jenkins, N.A. (1990). Chromosomal localization of seven members of the murine TGF-β superfamily suggests close linkage to several morphogenetic mutant loci. Genomics 6, 505-520.
Foroni, L., Boehm, T., White, L., Forster, A., Sherrington, P., Liao, X.B., Brannan, C.I., Jenkins, N.A., Copeland, N.G., Rabbitts, T.H. (1992). The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development. J. Mol. Biol. 226, 747-761.
Green, E.L. (1981) Linkage, recombination and mapping. In Genetics and Probability in Animal Breeding Experiments, (New York: Oxford University Press), pp. 77-113.
Hatta, M., Miyatani, S., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Takeichi, M. (1991). Genomic organization and chromosomal mapping of the mouse P-cadherin gene. Nucleic Acids Res. 19, 4437-4441.
Himmelbauer, H., Harvey, R.P., Copeland, N.G., Jenkins, N.A., Silver, L.M. (1994). High-resolution genetic analysis of a deletion on mouse Chromosome 17 extending over the fused, tufted, and homeobox Nkx2-5 loci. Mamm. Genome 5, 814-816.
Hosler, B.A., Rogers, M.B., Kozak, C.A., Gudas, L.J. (1993). An octamer motif contributes to the expression of the retinoic acid-regulated zinc finger gene Rex-1 (Zfp-42) in F9 teratocarcinoma cells. Mol. Cell. Biol. 13, 2919-2928.
Huebner, K., Druck, T., Croce, C.M., Thiesen, H.-J. (1991). Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. Am. J. Hum. Genet. 48, 726-740.
Jenkins, N.A., Copeland, N.G., Taylor, B.A., Lee, B.K. (1982). Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus. J. Virol. 43, 26-36.
Kirschner, M.A., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Amara, S.G. (1994). Mouse excitatory amino acid transporter EAAT2: Isolation, characterization, and proximity to neuroexcitability loci on mouse chromosome 2. Genomics 24, 218-224.
Lichter, P., Bray, P., Ried, T., Dawid, I.B., Ward, D.C. (1992). Clustering of C2H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. Genomics 13, 999-1007.
Margolin, J.F., Friedman, J.R., Meyer, W.K.-H., Vissing, H., Thiesen, H.-J., Rausher, F.J. (1994). Kruppel-associated boxes are potent transcriptional repression domains. Proc. Natl. Acad. Sci. USA 91, 4509-4513.
Marine, J.-C., Bellefroid, E.J., Bourguignon, C., Rivière, M., Lecoq, P.J., Poncelet, D.A., Szpirer, J., Martial, J.A., Szpirer, C. (1994). Assignment of human ZNF83 (HPF1) zinc finger gene to chromosome 19q13.3-q13.4. Genomics 21, 285-286.
Nadeau, J.H., Birkenmeier, C.S., Chowdhury, K., Crosby, J.L., Lalley, P.A. (1990). Zinc finger protein gene complexes on mouse chromosomes 8 and 11. Genomics 8, 468-476.
Noce, T., Fujiwara, Y., Ito, M., Takeuchi, T., Hashimoto, N., Yamanouchi, M., Higashinakagawa, T., Fujimoto, H. (1992). A novel murine zinc finger gene mapped within the tw18 deletion region expresses in germ cells and embryonic nervous system. Dev. Biol. 155, 409-422.
O'Hara, B., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Shows, T.B., Eddy, R.L., Bohlen, P., Kovesdi, I. (1995). Chromosomal assignment of the heparin-binding cytokine genes MDK and PTN in mouse and man. Cytogenet. Cell Genet. 69, 40-43.
Pengue, G., Calabro, V., Bartoli, P.C., Pagluica, A., Lania L. (1994). Repression of transcriptional activity at a distance by the evolutionarily conserved KRAB domain present in a subfamily of zinc finger proteins. Nucleic Acids Res. 22, 2908-2914.
Pieler, T., Bellefroid, E.J. (1994). Perspectives on zinc finger protein function and evolution - an update. Mol. Biol. Rep. 20, 1-8.
Sciaky, D., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Sonoda, G., Testa, J.R., Cohen, M.B. (1995). Mapping of guanylin to murine chromosome 4 and human chromosome 1p34-p35. Genomics 26, 427-429.
Singh, G., Kaur, S., Stock, J.L., Jenkins, N.A., Gilbert, D.j., Copeland, N.G., Potter, S.S. (1991). Identification of 10 murine homeobox genes. Proc. Natl. Acad. Sci. USA 88, 10706-10710.
Taylor, G.A., Lai, W.S., Oakey, R.J., Seldin, M.F., Shows, T.B., Eddy, Jr. R.L., Blackshear, P.J. (1991). The human TTP protein: sequence, alignment with related proteins, and chromosomal localization of the mouse and human genes. Nucleic Acids Res. 19, 3454.
Terajima, M., Matsui, Y., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Obinata, M. (1994). Structural organization of the mouse glycophorin A gene. J. Biochem. 116, 1105-1110.
Tessarollo, L., Tsoulfas, P., Martin-Zanca, D., Gilbert, D.J., Jenkins, N.A., Copeland, N.G., Parada, L.F. (1993). TrkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues. Development 118, 463-475.
Varnum, B.C., Ma, Q.F., Chi, T.H., Fletcher, B., Herschman, H.R. (1991). The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat. Mol. Cell. Biol. 11, 1754-1758.
Witzgall, R., O'Leary, E., Gessner, R., Ouellette, A.J., Bonventre, J.V. (1993). Kid-1, a putative renal transcription factor: regulation during ontogeny and in response to ischemia and toxic injury. Mol. Cell. Biol. 13, 1933-1942.
Witzgall, R., O'Leary, E., Leaf, A., Önaldi, D., Bonventre, J.V. (1994). The Krüppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression. Proc. Natl. Acad. Sci. USA 91, 4514-4518.
Wymore, R.S., Korenberg, J.R., Kinoshita, K.D., Aiyar, J., Coyne, C., Chen, X.-N., Hustad, C.M., Copeland, N.G., Gutman, G.A., Jenkins, N.A., Chandy, K.G. (1994). Genomic organization, nucleotide sequence, biophysical properties, and localization of the voltage-gated K+ channel gene KCNA4/Kv1.4 to mouse chromosome 2/human 11p14 and mapping of KCNC1/Kv3.1 to mouse 7/human 11p14.3-p15.2 and KCNA1/Kv1.1 to human 12p13. Genomics 20, 191-202.