[en] The mammalian genome contains hundreds if not thousands of zinc finger protein (Zfp) genes. While the function of most of these genes remains to be determined, it is clear that a few of them play important roles in gene regulation and development. In studies described here, we have used an interspecific mouse backcross mapping panel to determine the chromosomal location of 15 KRAB-containing zinc finger loci. These loci map to nine different mouse autosomes and the X Chromosome (Chr). Two Chrs, 7 and 9, contain cosegregating pairs of KRAB-containing Zfp genes, indicating that the KRAB-containing Zfp genes have evolved through processes involving regional as well as genome-wide duplication events.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Marine, J. C.; Université de Liège - ULiège
Gilbert, D. J.; NCI-Frederick Cancer Research and Development Center
Bellefroid, Eric J.; Georg-August Universität Göttingen
Martial, Joseph ; Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Ihle, J. N.; St. Jude Children’s Research Hospital
Copeland, N. G.; NCI-Frederick Cancer Research and Development Center
Jenkins, N. A.; NCI-Frederick Cancer Research and Development Center
Language :
English
Title :
Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci
Publication date :
1996
Journal title :
Mammalian Genome
ISSN :
0938-8990
eISSN :
1432-1777
Publisher :
Springer Verlag, New York, United States - New York
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