[en] (1) Background: infective endocarditis (IE) is a significant health concern associated with important morbidity and mortality. Only limited, often monocentric, retrospective data on IE in Belgium are available. This prospective study sought to assess the clinical characteristics and outcomes of Belgian IE patients in the ESC EORP European endocarditis (EURO-ENDO) registry; (2) Methods: 132 IE patients were identified based on the ESC 2015 criteria and included in six tertiary hospitals in Belgium; (3) Results: The average Belgian IE patient was male and 62.8 ± 14.9 years old. The native valve was most affected (56.8%), but prosthetic/repaired valves (34.1%) and intracardiac device-related (5.3%) IE are increasing. The most frequently identified microorganisms were S. aureus (37.2%), enterococci (15.5%), and S. viridans (15.5%). The most frequent complications were acute renal failure (36.2%) and embolic events (23.6%). Cardiac surgery was effectively performed when indicated in 71.7% of the cases. In-hospital mortality occurred in 15.7% of patients. Predictors of mortality in the multivariate analysis were S. aureus (HR = 2.99 [1.07-8.33], p = 0.036) and unperformed cardiac surgery when indicated (HR = 19.54 [1.91-200.17], p = 0.012). (4) Conclusion: This prospective EURO-ENDO ancillary analysis provides valuable contemporary insights into the profile, treatment, and clinical outcomes of IE patients in Belgium.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Roosens, Bram ; Centrum voor Hart-en Vaatziekten (CHVZ), Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), 1090 Brussels, Belgium.
Cosyns, Bernard; Centrum voor Hart-en Vaatziekten (CHVZ), Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), 1090 Brussels, Belgium.
Lancellotti, Patrizio ; Université de Liège - ULiège > Département des sciences cliniques > Cardiologie - Pathologie spéciale et réhabilitation
Laroche, Cécile; EURObservational Research Programme, European Society of Cardiology, 06903 Biot, France.
Selton-Suty, Christine ; EURObservational Research Programme, European Society of Cardiology, 06903 Biot, France. ; Department of Cardiology, Centre Hospitalier Universitaire de Nancy, 54000 Nancy, France.
Pasquet, Agnès ; Divisions of Cardiology and Cardiothoracic Surgery, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium.
De Sutter, Johan; Hartcentrum Gent, Algemeen Ziekenhuis Maria Middelares, 9000 Ghent, Belgium.
Unger, Philippe ; Centrum voor Hart-en Vaatziekten (CHVZ), Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), 1090 Brussels, Belgium. ; Department of Cardiology, Centre Hospitalier Universitaire Saint-Pierre, 1000 Brussels, Belgium.
Paelinck, Bernard; Centrum voor Hart-en Vaatziekten (CHVZ), Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), 1090 Brussels, Belgium. ; Department of Cardiology, Universitair Ziekenhuis (UZ) Antwerpen, 2650 Antwerp, Belgium.
Vermeersch, Paul ; Centrum voor Hart-en Vaatziekten (CHVZ), Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), 1090 Brussels, Belgium. ; Hartcentrum, Ziekenhuis Netwerk Antwerpen (ZNA), 2020 Antwerp, Belgium.
Motoc, Andreea; Centrum voor Hart-en Vaatziekten (CHVZ), Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), 1090 Brussels, Belgium.
Galloo, Xavier ; Centrum voor Hart-en Vaatziekten (CHVZ), Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), 1090 Brussels, Belgium.
Iung, Bernard; Department of Cardiology, Bichat Hospital, APHP, Université Paris-Cité, 75018 Paris, France.
Habib, Gilbert; APHM, La Timone Hospital, Cardiology Department, Marseille, France & Aix Marseille University, IRD, APHM, MEPHI, IHU-Mediterranean Infection, 13005 Marseille, France.
Habib G. Management of Infective Endocarditis Heart 2006 92 124 130 10.1136/hrt.2005.063719
Delgado V. Ajmone Marsan N. De Waha S. Bonaros N. Brida M. Burri H. Caselli S. Doenst T. Ederhy S. Erba P.A. et al. 2023 ESC Guidelines for the Management of Endocarditis Eur. Heart J. 2023 44 3948 4042 10.1093/eurheartj/ehad193 37622656
Momtazmanesh S. Moghaddam S.S. Rad E.M. Azadnajafabad S. Ebrahimi N. Mohammadi E. Rouhifard M. Rezaei N. Masinaei M. Rezaei N. et al. Global, Regional, and National Burden and Quality of Care Index of Endocarditis: The Global Burden of Disease Study 1990–2019 Eur. J. Prev. Cardiol. 2022 29 1287 1297 10.1093/eurjpc/zwab211 34897404
Habib G. Lancellotti P. Antunes M.J. Bongiorni M.G. Casalta J.P. Del Zotti F. Dulgheru R. El Khoury G. Erba P.A. Iung B. et al. 2015 ESC Guidelines for the Management of Infective Endocarditis Eur. Heart J. 2015 36 3075 3123 10.1093/eurheartj/ehv319
Motoc A. Kessels J. Roosens B. Lacor P. Van de Veire N. De Sutter J. Magne J. Droogmans S. Cosyns B. Impact of the Initial Clinical Presentation on the Outcome of Patients with Infective Endocarditis Cardiol. J. 2023 30 385 390 10.5603/CJ.a2021.0075 34240402
Poesen K. Pottel H. Colaert J. De Niel C. Epidemiology of Infective Endocarditis in a Large Belgian Non-Referral Hospital Acta Clin. Belg. 2014 69 183 190 10.1179/0001551214Z.00000000046
Yombi J.C. Yuma S.N. Pasquet A. Astarci P. Robert A. Rodriguez H.V. Staphylococcal versus Streptococcal Infective Endocarditis in a Tertiary Hospital in Belgium: Epidemiology, Clinical Characteristics and Outcome Acta Clin. Belgica Int. J. Clin. Lab. Med. 2017 72 417 423 10.1080/17843286.2017.1309341 28372481
Tahon J. Geselle P.J. Vandenberk B. Hill E.E. Peetermans W.E. Herijgers P. Janssens S. Herregods M.C. Long-Term Follow-up of Patients with Infective Endocarditis in a Tertiary Referral Center Int. J. Cardiol. 2021 331 176 182 10.1016/j.ijcard.2021.01.048
Habib G. Lancellotti P. Erba P.A. Sadeghpour A. Meshaal M. Sambola A. Furnaz S. Citro R. Ternacle J. Donal E. et al. The ESC-EORP EURO-ENDO (European Infective Endocarditis) Registry Eur. Heart J. Qual. Care Clin. Outcomes 2019 5 202 207 10.1093/ehjqcco/qcz018
Habib G. Erba P.A. Iung B. Donal E. Cosyns B. Laroche C. Popescu B.A. Prendergast B. Tornos P. Sadeghpour A. et al. Clinical Presentation, Aetiology and Outcome of Infective Endocarditis. Results of the ESC-EORP EURO-ENDO (European Infective Endocarditis) Registry: A Prospective Cohort Study Eur. Heart J. 2019 40 3222 3232B 10.1093/eurheartj/ehz620
Arora N. Panda P.K. CR P. Uppal L. Saroch A. Angrup A. Sharma N. Sharma Y.P. Vijayvergiya R. Rohit M.K. et al. Changing Spectrum of Infective Endocarditis in India: An 11-Year Experience from an Academic Hospital in North India Indian Heart J. 2021 73 711 717 10.1016/j.ihj.2021.09.008
Liaqat W. Palaiodimos L. Li W. Karamanis D. Tahir A. Tzoumas A. Nagraj S. Tiwari N. Grushko M. Kokkinidis D. et al. Epidemiologic and Clinical Characteristics of Infective Endocarditis: A Single-Center Retrospective Study in the Bronx, New York Infection 2022 50 1349 1361 10.1007/s15010-022-01846-3 35614176
Solari S. Tamer S. Aphram G. Mastrobuoni S. Navarra E. Noirhomme P. Poncelet A. Astarci P. Rubay J. El Khoury G. et al. Aortic Valve Repair in Endocarditis: Scope and Results Indian J. Thorac. Cardiovasc. Surg. 2020 36 104 112 10.1007/s12055-019-00831-0
Hoen B. Alla F. Selton-Suty C. Béguinot I. Bouvet A. Briançon S. Casalta J.P. Danchin N. Delahaye F. Etienne J. et al. Changing Profile of Infective Endocarditis: Results of a 1-Year Survey in France JAMA 2002 288 75 81 10.1001/jama.288.1.75 12090865
Murdoch D.R. Corey R.G. Hoen B. Miró M. Fowler V.G. Bayer A.S. Karchmer A.W. Olaison L. Pappas P.A. Moreillon P. et al. Clinical Presentation, Etiology, and Outcome of Infective Endocarditis in the 21st Century the International Collaboration on Endocarditis-Prospective Cohort Study Arch. Intern. Med. 2009 169 463 473 10.1001/archinternmed.2008.603
Cosyns B. Roosens B. Lancellotti P. Laroche C. Dulgheru R. Scheggi V. Vilacosta I. Pasquet A. Piper C. Reyes G. et al. Cancer and Infective Endocarditis: Characteristics and Prognostic Impact Front. Cardiovasc. Med. 2022 8 766996 10.3389/fcvm.2021.766996
von Kemp B. Belgian Guidelines on Supportive Care: Cardiotoxicity of Cancer Treatments Belgian J. Med. Oncol. 2021 15 367 373
Kong W.K.F. Salsano A. Giacobbe D.R. Popescu B.A. Laroche C. Duval X. Schueler R. Moreo A. Colonna P. Piper C. et al. Outcomes of Culture-Negative vs. Culture-Positive Infective Endocarditis: The ESC-EORP EURO-ENDO Registry Eur. Heart J. 2022 43 2770 2780 10.1093/eurheartj/ehac307
Sambola A. Lozano-Torres J. Boersma E. Olmos C. Ternacle J. Calvo F. Tribouilloy C. Reskovic-Luksic V. Separovic-Hanzevacki J. Park S.-W. et al. Predictors of Embolism and Death in Left-Sided Infective Endocarditis: The European Society of Cardiology EURObservational Research Programme European Infective Endocarditis Registry Eur. Heart J. 2023 44 4566 4575 10.1093/eurheartj/ehad507
Kim K. Kim D. Lee S.E. Cho I.J. Shim C.Y. Hong G.R. Ha J.W. Infective Endocarditis in Cancer Patients: Causative Organisms, Predisposing Procedures, and Prognosis Differ from Infective Endocarditis in Non-Cancer Patients Circ. J. 2019 83 452 460 10.1253/circj.CJ-18-0609
Oliver L. Lavoute C. Giorgi R. Salaun E. Hubert S. Casalta J.P. Gouriet F. Renard S. Saby L. Avierinos J.F. et al. Infective Endocarditis in Octogenarians Heart 2017 103 1602 1609 10.1136/heartjnl-2016-310853 28432160
Fernández-Cruz A. Muñoz P. Sandoval C. Fariñas-Álvarez M.C. Gutiérrez-Cuadra M. Pericás Pulido J.M. Miró J.M. Goenaga-Sánchez M. De Alarcón A. Bonache-Bernal F. et al. Infective Endocarditis in Patients with Cancer: A Consequence of Invasive Procedures or a Harbinger of Neoplasm? A Prospective, Multicenter Cohort Medicine 2017 96 e7913 10.1097/MD.0000000000007913 28930826
Habib G. Badano L. Tribouilloy C. Vilacosta I. Zamorano J.L. Galderisi M. Voigt J.U. Sicari R. Cosyns B. Fox K. et al. Recommendations for the Practice of Echocardiography in Infective Endocarditis Eur. J. Echocardiogr. 2010 11 202 219 10.1093/ejechocard/jeq004 20223755
El Kadi S. van den Buijs D.M.F. Meijers T. Gilbers M.D. Bekkers S.C.A.M. van Melle J.P. Riezebos R.K. Blok W.L. Tanis W. Wahadat A.R. et al. Infective Endocarditis in the Netherlands: Current Epidemiological Profile and Mortality: An Analysis Based on Partial ESC EORP Collected Data Netherlands Heart J. 2020 28 526 536 10.1007/s12471-020-01431-z
Iung B. Baron G. Butchart E.G. Delahaye F. Gohlke-Bärwolf C. Levang O.W. Tornos P. Vanoverschelde J.L. Vermeer F. Boersma E. et al. A Prospective Survey of Patients with Valvular Heart Disease in Europe: The Euro Heart Survey on Valvular Heart Disease Eur. Heart J. 2003 24 1231 1243 10.1016/S0195-668X(03)00201-X
Tornos P. Iung B. Permanyer-Miralda G. Baron G. Delahaye F. Gohlke-Bärwolf C. Butchart E.G. Ravaud P. Vahanian A. Infective Endocarditis in Europe: Lessons from the Euro Heart Survey Heart 2005 91 571 575 10.1136/hrt.2003.032128
Toyoda N. Itagaki S. Egorova N.N. Tannous H. Anyanwu A.C. El-Eshmawi A. Adams D.H. Chikwe J. Real-World Outcomes of Surgery for Native Mitral Valve Endocarditis J. Thorac. Cardiovasc. Surg. 2017 154 1906 1912.e9 10.1016/j.jtcvs.2017.07.077
Charlson M. Szatrowski T.P. Peterson J. Gold J. Validation of a Combined Comorbidity Index J. Clin. Epidemiol. 1994 47 1245 1251 10.1016/0895-4356(94)90129-5
