Alzheimer’s disease; asymmetry; autopsy; brainstem; locus coeruleus; neurons; tangles; Psychiatry and Mental health; Geriatrics and Gerontology; Clinical Psychology; General Medicine; General Neuroscience
Abstract :
[en] Tau accumulation in and neurodegeneration of locus coeruleus (LC) neurons is observed in Alzheimer's disease (AD). We investigated whether tangle and neuronal density in the rostral and caudal LC is characterized by an asymmetric pattern in 77 autopsy cases of the Rush Memory and Aging Project. We found left-right equivalence for tangle density across individuals with and without AD pathology. However, neuronal density, particularly in the caudal-rostral axis of the LC, is asymmetric among individuals with AD pathology. Asymmetry in LC neuronal density may signal advanced disease progression and should be considered in AD neuroimaging studies of LC neurodegeneration.
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Beckers, Elise ; Université de Liège - ULiège > GIGA ; Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, The Netherlands
Riphagen, Joost M; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA ; Harvard Medical School, Boston, MA, USA
Van Egroo, Maxime; Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, The Netherlands
Bennett, David A; Rush Alzheimer's Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
Jacobs, Heidi I L; Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, The Netherlands ; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA ; Harvard Medical School, Boston, MA, USA
Language :
English
Title :
Sparse Asymmetry in Locus Coeruleus Pathology in Alzheimer's Disease.
