Bio-mineralization of virus-like particles by metal–organic framework nanoparticles enhances the thermostability and immune responses of the vaccines.pdf
Metal-Organic Frameworks; Vaccines, Virus-Like Particle; Animals; Immunity; Foot-and-Mouth Disease Virus; Nanoparticles; Bio mineralizations; Cold chain; Core shell; Imidazol; Immune response; Immunogenicity; Metalorganic frameworks (MOFs); Storage and transportations; Virus-like particles; Chemistry (all); Biomedical Engineering; Materials Science (all); General Materials Science; General Chemistry; General Medicine
Abstract :
[en] Virus-like particle (VLPs) vaccines have been extensively studied due to their good immunogenicity and safety; however, they highly rely on cold-chain storage and transportation. Nanotechnology of bio-mineralization as a useful strategy has been employed to improve the thermal stability and immunogenicity of VLPs. A zeolitic imidazole framework (ZIF-8), a core-shell structured nanocomposite, was applied to encapsulate foot-and-mouth disease virus (FMDV) VLPs. It was found that the ZIF-8 shell enhanced the heat resistance of VLPs and promoted their ability to be taken up by cells and escape from lysosomes. The VLPs-ZIF-8 easily activated antigen-presenting cells (APCs), triggered higher secretion levels of cytokines, and elicited stronger immune responses than VLPs alone even after being treated at 37 °C for 7 days. This platform has good potential in the development of VLP-based vaccine products without transportation.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Teng, Zhidong; State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou 730046, Gansu, P. R. China. sunshiqi@caas.cn
Hou, Fengping ; State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou 730046, Gansu, P. R. China. sunshiqi@caas.cn ; Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (Gembloux Agro-Bio Tech), University of Liège (ULg), Avenue de l'Hôpital, 11, 4000 Liège, Belgium
Bai, Manyuan; State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou 730046, Gansu, P. R. China. sunshiqi@caas.cn
Li, Jiajun; State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou 730046, Gansu, P. R. China. sunshiqi@caas.cn
Wang, Jun ; State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou 730046, Gansu, P. R. China. sunshiqi@caas.cn
Wu, Jinen; State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou 730046, Gansu, P. R. China. sunshiqi@caas.cn
Ru, Jiaxi; State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou 730046, Gansu, P. R. China. sunshiqi@caas.cn
Ren, Mei ; Université de Liège - ULiège > TERRA Research Centre ; State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou 730046, Gansu, P. R. China. sunshiqi@caas.cn
Sun, Shiqi; State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou 730046, Gansu, P. R. China. sunshiqi@caas.cn
Guo, Huichen ; State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou 730046, Gansu, P. R. China. sunshiqi@caas.cn ; School of Animal Science, Yangtze University, Jingmi Street, Jingzhou District, Jingzhou 434025, P. R. China ; Yunnan Tropical and Subtropical Animal Virus Diseases Laboratory, Yunnan Animal Science and Veterinary Institute, Kunming, Yunnan, China
Language :
English
Title :
Bio-mineralization of virus-like particles by metal-organic framework nanoparticles enhances the thermostability and immune responses of the vaccines.
NSCF - National Natural Science Foundation of China
Funding text :
This work was supported by grants from the National Key Research and Development Program (2021YFD1800300) and the National Natural Science Foundation of China (32002272, 31873023, 32072847, and 32072859).
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