TRPA5 encodes a thermosensitive ankyrin ion channel receptor in a triatomine insect

Lienard, Marjorie; Baez-Nieto, David; Tsai, Cheng-Chia; Valencia-Montoya, Wendy A.; Werin, Balder; Johanson, Urban; Lassance, Jean-Marc; Pan, Jen Q.; Yu, Nanfang; Pierce, Naomi E.

doi:10.1016/j.isci.2024.109541

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TRPA5 encodes a thermosensitive ankyrin ion channel receptor in a triatomine insect

Lienard, Marjorie; Baez-Nieto, David; Tsai, Cheng-Chia et al.

2024 • In iScience, 27 (4), p. 109541

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https://hdl.handle.net/2268/315817

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10.1016/j.isci.2024.109541

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Keywords :

TRP; temperature sensing; noxious; Rhodnius prolixus; kissing bug

Abstract :

[en] As ectotherms, insects need heat-sensitive receptors to monitor environmental temperatures and facilitate thermoregulation. We show that TRPA5, a class of ankyrin transient receptor potential (TRP) channels absent in dipteran genomes, may function as insect heat receptors. In the triatomine bug Rhodnius prolixus (order: Hemiptera), a vector of Chagas disease, the channel RpTRPA5B displays a uniquely high thermosensitivity, with biophysical determinants including a large channel activation enthalpy change (72 kcal/mol), a high temperature coefficient (Q10 = 25), and in vitro temperature-induced currents from 53°C to 68°C (T0.5 = 58.6°C), similar to noxious TRPV receptors in mammals. Monomeric and tetrameric ion channel structure predictions show reliable parallels with fruit fly dTRPA1, with structural uniqueness in ankyrin repeat domains, the channel selectivity filter, and potential TRP functional modulator regions. Overall, the finding of a member of TRPA5 as a temperature-activated receptor illustrates the diversity of insect molecular heat detectors.

Disciplines :

Life sciences: Multidisciplinary, general & others

Author, co-author :

Lienard, Marjorie ^✱; Université de Liège - ULiège > GIGA > GIGA Molecular Biology of Diseases

Baez-Nieto, David ^✱

Tsai, Cheng-Chia

Valencia-Montoya, Wendy A.

Werin, Balder

Johanson, Urban

Lassance, Jean-Marc ; Université de Liège - ULiège > Département de gestion vétérinaire des Ressources Animales (DRA) > Génomique animale

Pan, Jen Q.

Yu, Nanfang

Pierce, Naomi E.

^✱ These authors have contributed equally to this work.

Language :

English

Title :

TRPA5 encodes a thermosensitive ankyrin ion channel receptor in a triatomine insect

Publication date :

April 2024

Journal title :

iScience

eISSN :

2589-0042

Publisher :

Elsevier BV

Volume :

Issue :

Pages :

109541

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:S2589004224007636?httpAccept=text/xml

Funders :

KAW - Knut and Alice Wallenberg Foundation [SE]
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
NSF - National Science Foundation [US-VA]
Sverige Vetenskapsrådet [SE]
Carl Tryggers Stiftelse för Vetenskaplig Forskning [SE]

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