Article (Scientific journals)
Estimating Glomerular Filtration Rate in China: Is the European Kidney Function Consortium (EKFC) Equation the Solution?
Delanaye, Pierre; Pottel, Hans
2024In Nephron journals, 148 (2), p. 74 - 77
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Keywords :
Creatinine; Estimating equation; Glomerular filtration rate; Cystatin C; Adolescent; Young Adult; Humans; Child, Preschool; Child; Adult; Middle Aged; Aged; Aged, 80 and over; Glomerular Filtration Rate; China; Kidney; Renal Insufficiency, Chronic; Physiology; Nephrology; Urology; Physiology (medical)
Abstract :
[en] The new European Kidney Function Consortium (EKFC) creatinine-based equation has been developed to be applicable over the entire age range (from 2 to 100 years) without any loss of performance in young adults and without loss of continuity in estimating glomerular filtration rate (GFR) between adolescents and adults. This goal is obtained by better taking into account the relationship between serum creatinine (SCr) and age in the estimating GFR model. This is accomplished by rescaling SCr, namely, dividing SCr by so-called Q value which is the median normal value of SCr concentration in a given healthy population. The better performance of the EKFC equation, compared to the current equations, has been shown in large European and African cohorts. Such good results are also suggested in cohorts from China, including in the current issue of Nephron. The good performance of the EKFC equation is observed, especially when the authors used a specific Q value for their populations notwithstanding GFR was measured by a controversial method. Using a population-specific Q value could make the EFKC equation universally applicable.
Disciplines :
Urology & nephrology
Author, co-author :
Delanaye, Pierre  ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale ; Department of Nephrology-Dialysis-Apheresis, Hôpital Universitaire Carémeau, Nîmes, France
Pottel, Hans ;  Université de Liège - ULiège > Département des sciences cliniques ; Department of Public Health and Primary Care, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium
Language :
English
Title :
Estimating Glomerular Filtration Rate in China: Is the European Kidney Function Consortium (EKFC) Equation the Solution?
Publication date :
2024
Journal title :
Nephron journals
ISSN :
1660-8151
eISSN :
2235-3186
Publisher :
S. Karger AG, Switzerland
Volume :
148
Issue :
2
Pages :
74 - 77
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 20 February 2024

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