Emulsifiers during gestation: The risks of ultra-processed food revealed in mice.

[en] Several dietary components disrupt the control of energy balance. A new study in PLOS Biology shows that, in mice, maternal consumption of emulsifiers induces a rewiring of the hypothalamic feeding circuits and causes neuropsychological impairment in the offspring.

Disciplines :

Endocrinology, metabolism & nutrition
Pediatrics

Author, co-author :

Franssen, Delphine ; Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie ; Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.

Parent, Anne-Simone ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pédiatrie

Language :

English

Title :

Emulsifiers during gestation: The risks of ultra-processed food revealed in mice.

Publication date :

August 2023

Journal title :

PLoS Biology

ISSN :

1544-9173

eISSN :

1545-7885

Publisher :

Public Library of Science, Us ca

Volume :

Issue :

Pages :

e3002265

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Copyright: © 2023 Franssen, Parent. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Available on ORBi :

since 15 February 2024

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Bibliography

Katzmarzyk PT, Broyles ST, Champagne CM, Chaput JP, Fogelholm M, Hu G, et al. Relationship between Soft Drink Consumption and Obesity in 9–11 Years Old Children in a Multi-National Study. Nutrients. 2016; 8:770. https://doi.org/10.3390/nu8120770 PMID: 27916866
Sylvetsky AC, Jin Y, Mathieu K, DiPietro L, Rother KI, Talegawkar SA. Low-Calorie Sweeteners: Disturbing the Energy Balance Equation in Adolescents? Obesity. 2017; 25:2049–2054. https://doi.org/10.1002/oby.22005 PMID: 29086493
Buckley JP, Kim H, Wong E, Rebholz CM. Ultra-processed food consumption and exposure to phthalates and bisphenols in the US National Health and Nutrition Examination Survey, 2013–2014. Environ Int. 2019; 131:105057. https://doi.org/10.1016/j.envint.2019.105057 PMID: 31398592
Park S, Belfoul AM, Rastelli M, Jang A, Monnoye M, Bae H, et al. Maternal low-calorie sweetener consumption rewires hypothalamic melanocortin circuits via a gut microbial co-metabolite pathway. JCI Insight. 2023; 8:e156397. https://doi.org/10.1172/jci.insight.156397 PMID: 37014702
Milà-Gausch M, Ramírez S, Llana SR, Fos-Domènech J, Dropmann LM, Pozo M, et al. Maternal emulsifier consumption programs offspring metabolic and neuropsychological health. PLoS Biol. 2023; 21(8):e3002171. https://doi.org/10.1371/journal.pbio.3002171
Barker DJ, Winter PD, Osmond C, Margetts B, Simmonds SJ. Weight in infancy and death from ischaemic heart disease. Lancet. 1989; 2(8663):577–580. https://doi.org/10.1016/s0140-6736(89)90710-1 PMID: 2570282
Heindel JJ. History of the Obesogen Field: Looking Back to Look Forward. Front Endocrinol (Lausanne). 2019; 10:14.
Bouret SG. Development of Hypothalamic Circuits That Control Food Intake and Energy Balance. In: Harris RBS, editor. Appetite and Food Intake: Central Control. 2nd ed. Boca Raton (FL): CRC Press/ Taylor & Francis; 2017. p. 135–154.
Egusquiza RJ, Blumberg B. Environmental Obesogens and Their Impact on Susceptibility to Obesity: New Mechanisms and Chemicals. Endocrinology. 2020; 161:bqaa024. https://doi.org/10.1210/endocr/ bqaa024 PMID: 32067051
Mackay H, Patterson ZR, Khazall R, Patel S, Tsirlin D, Abizaid A. Organizational effects of perinatal exposure to bisphenol-A and diethylstilbestrol on arcuate nucleus circuitry controlling food intake and energy expenditure in male and female CD-1 mice. Endocrinology. 2013; 154:1465–1475. https://doi.org/10.1210/en.2012-2044 PMID: 23493373
Marraudino M, Ponti G, Moussu C, Farinetti A, Macchi E, Accornero P, et al. Early Postnatal Genistein Administration Affects Mice Metabolism and Reproduction in a Sexually Dimorphic Way. Metabolites. 2021; 11:449. https://doi.org/10.3390/metabo11070449 PMID: 34357343
Patisaul HB. Achieving CLARITY on bisphenol A, brain and behaviour. J Neuroendocrinol. 2020; 32: e12730. https://doi.org/10.1111/jne.12730 PMID: 31063678