Article (Scientific journals)
Linking clinical and population-based data in older patients with cancer in Belgium: Feasibility and clinical outcomes.
Depoorter, Victoria; Vanschoenbeek, Katrijn; Decoster, Lore et al.
2023In Journal of Geriatric Oncology, 14 (2), p. 101428
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Keywords :
Cancer; Data linkage; Geriatric assessment; Geriatric risk factors; Geriatric screening; Older persons; Overall survival; Population-based data; Aged; Humans; Belgium/epidemiology; Cohort Studies; Feasibility Studies; Prospective Studies; Geriatric Assessment/methods; Neoplasms/epidemiology; Belgium; Neoplasms; Oncology; Geriatrics and Gerontology
Abstract :
[en] [en] INTRODUCTION: Geriatric screening and geriatric assessment (GS/GA) have proven their benefits in the care for older patients with cancer. However, less is known about the predictive value of GS/GA for outcomes. To research this, clinical data on GS/GA can be enriched with population-based data. In this article we describe the methods and feasibility of data linkage, and first clinical outcomes (GS/GA results and overall survival). MATERIALS AND METHODS: A large cohort study consisting of patients aged ≥70 years with a new cancer diagnosis was established using linked data from clinical and population-based databases. Clinical data were derived from a previous prospective study where older patients with cancer were screened with G8, followed by GA in case of an abnormal result (GS/GA study; 2009-2015). These data were linked to cancer registration data from the Belgian Cancer Registry (BCR), reimbursement data of the health insurance companies (InterMutualistic Agency, IMA), and hospital discharge data (Technical Cell, TCT). Cox regression analyses were conducted to evaluate the prognostic value of the G8 geriatric screening tool. RESULTS: Of the 8067 eligible patients with a new cancer diagnosis, linkage of data from the GS/GA study and data from the BCR was successful for 93.7%, resulting in a cohort of 7556 patients available for the current analysis. Further linkage with the IMA and TCT database resulted in a cohort of 7314 patients (96.8%). Based on G8 geriatric screening, 67.9% of the patients had a geriatric risk profile. Malnutrition and functional dependence were the most common GA-identified risk factors. An abnormal baseline G8 score (≤14/17) was associated with lower overall survival (adjusted HR [aHR] = 1.62 [1.50-1.75], p < 0.001). DISCUSSION: Linking clinical and population-based databases for older patients with cancer has shown to be feasible. The GS/GA results at cancer diagnosis demonstrate the vulnerability of this population and the G8 score showed prognostic value for overall survival. The established cohort of almost 8000 patients with long-term follow-up will serve as a basis in the future for detailed analyses on long-term outcomes beyond survival.
Disciplines :
Author, co-author :
Depoorter, Victoria;  KU Leuven, Department of Oncology, Leuven, Belgium
Vanschoenbeek, Katrijn;  Belgian Cancer Registry, Research Department, Brussels, Belgium
Decoster, Lore;  Universitair Ziekenhuis Brussel - Vrije Universiteit Brussel, Oncologisch Centrum - Department of Medical Oncology, Brussels, Belgium
De Schutter, Harlinde;  Belgian Cancer Registry, Research Department, Brussels, Belgium
Debruyne, Philip R;  General Hospital Groeninge, Kortrijk Cancer Centre, Kortrijk, Belgium, Anglia Ruskin University, Medical Technology Research Centre (MTRC), School of Life Sciences, Cambridge, UK, University of Plymouth, School of Nursing & Midwifery, Plymouth, UK
De Groof, Inge;  Iridium Cancer Network Antwerp - Sint-Augustinus, Department of Geriatric Medicine, Wilrijk, Belgium
Bron, Dominique;  ULB Institute Jules Bordet, Department of Hematology, Brussels, Belgium
Cornélis, Frank;  Cliniques Universitaires Saint-Luc - UCLouvain, Department of Medical Oncology, Brussels, Belgium
Luce, Sylvie;  University Hospital Erasme- Université Libre de Bruxelles ULB, Department Medical Oncology, Brussels, Belgium
Focan, Christian;  Clinique CHC-MontLégia, Groupe Santé CHC-Liège, Department of Oncology, Liège, Belgium
Verschaeve, Vincent;  GHDC Grand Hôpital de Charleroi, Department of Medical Oncology, Charleroi, Belgium
Debugne, Gwenaëlle;  Centre Hospitalier de Mouscron, Department of Geriatric Medicine, Mouscron, Belgium
Langenaeken, Christine;  AZ Klina, Department of Medical Oncology, Brasschaat, Belgium
Van Den Bulck, Heidi;  Imelda Hospital, Department of Medical Oncology, Bonheiden, Belgium
Goeminne, Jean-Charles;  CHU-UCL-Namur, Department of Medical Oncology, Namur, Belgium
Teurfs, Wesley;  ZNA Stuivenberg, Department Medical Oncology, Antwerp, Belgium
Jerusalem, Guy  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service d'oncologie médicale
Schrijvers, Dirk;  ZNA Middelheim, Department of Medical Oncology, Antwerp, Belgium
Petit, Bénédicte;  Centre Hospitalier Jolimont, Department of Medical Oncology, La Louvière, Belgium
Rasschaert, Marika;  University Hospital Antwerp, Department of Medical Oncology, Edegem, Belgium
Praet, Jean-Philippe;  CHU St-Pierre - Free Universities Brussels, Department of Geriatric Medicine, Brussels, Belgium
Vandenborre, Katherine;  AZ Vesalius, Department of Medical Oncology, Tongeren, Belgium
Milisen, Koen;  University Hospitals Leuven - KU Leuven, Department of Geriatric Medicine - Department of Public Health and Primary Care, Academic Centre for Nursing and Midwifery, Leuven, Belgium
Flamaing, Johan;  University Hospitals Leuven - KU Leuven, Department of Geriatric Medicine - Department of Public Health and Primary Care, Gerontology and Geriatrics, Leuven, Belgium
Kenis, Cindy;  University Hospitals Leuven, Department of General Medical Oncology - Department of Geriatric Medicine, Leuven, Belgium
Verdoodt, Freija;  Belgian Cancer Registry, Research Department, Brussels, Belgium
Wildiers, Hans;  University Hospitals Leuven - KU Leuven, Department of General Medical Oncology - Department of Oncology, Leuven, Belgium. Electronic address:
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Title :
Linking clinical and population-based data in older patients with cancer in Belgium: Feasibility and clinical outcomes.
Publication date :
March 2023
Journal title :
Journal of Geriatric Oncology
Publisher :
Elsevier Ltd, Netherlands
Volume :
Issue :
Pages :
Peer reviewed :
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Funding text :
The research project received funding from Kom op tegen Kanker (Stand up to Cancer), the Flemish cancer society . HW is a recipient of the Fonds voor Wetenschappelijk Onderzoek – Vlaanderen (funds from The Research Foundation – Flanders). The funders had no involvement in study design, analysis and interpretation of the data, writing of the report, and the decision to submit this article for publication.
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