Article (Scientific journals)
Clinical practice of hereditary angioedema in Belgium: opportunities for optimized care.
Ebo, D G; Van der Poorten, M M; Van Gasse, A L et al.
2023In Acta Clinica Belgica, 78 (6), p. 431 - 437
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Keywords :
Hereditary angioedema; Medicine (all); General Medicine
Abstract :
[en] [en] INTRODUCTION: Hereditary angioedema (HAE) is a rare disorder characterized by unpredictable painful and potentially life-threatening swelling episodes. The international WAO/EAACI guideline on the diagnosis and management of HAE was recently updated and provides up-to-date guidance for the management of. In this paper, we assessed to what extent the Belgian clinical practice was aligned with the revised guideline, and whether there were opportunities to optimise Belgian clinical practice in HAE. METHODS: We compared the updated international guideline for HAE with information we acquired on Belgian clinical practice, a Belgian patient registry and expert opinion analysis. The Belgian patient registry was developed with the involvement of eight Belgian reference centers for HAE patients. Eight Belgian experts, physicians in the participating centers, included patients in the patient registry and participated in the expert opinion analysis. RESULTS: The main action points to further optimise the Belgian clinical practice of HAE are Work towards total disease control and normalize patients' life by considering the use of new and innovative long-term prophylactic treatment options; (2) inform C1-INH-HAE patients about new long-term prophylactic therapies; (3) assure the availability of on-demand therapy for all C1-INH-HAE patients; (4) implement a more universally used assessment including multiple aspects of the disease (e.g. quality of life assessment) in daily clinical practice; and (5) continue and expand an existing patient registry to assure continued data availability on C1-INH-HAE in Belgium. CONCLUSIONS: In light of the updated WAO/EAACI guideline, five action points were identified and several other suggestions were made to optimise the Belgian clinical practice in C1-INH-HAE.
Disciplines :
Immunology & infectious disease
Author, co-author :
Ebo, D G ;  Faculty of Medicine and Health Science, Department of Immunology - Allergology - Rheumatology, Antwerp University Hospital and the Infla-Med Center of Excellence, University of Antwerp, Antwerp, Belgium
Van der Poorten, M M ;  Faculty of Medicine and Health Science, Department of Immunology - Allergology - Rheumatology, Antwerp University Hospital and the Infla-Med Center of Excellence, University of Antwerp, Antwerp, Belgium ; Faculty of Medicine and Health Science, Department of Paediatrics, University of Antwerp, Antwerp University Hospital, Antwerp, Belgium
Van Gasse, A L ;  Faculty of Medicine and Health Science, Department of Immunology - Allergology - Rheumatology, Antwerp University Hospital and the Infla-Med Center of Excellence, University of Antwerp, Antwerp, Belgium ; Faculty of Medicine and Health Science, Department of Paediatrics, University of Antwerp, Antwerp University Hospital, Antwerp, Belgium
Schrijvers, R ;  Faculty of Medicine, Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, Leuven, KU, Belgium
Hermans, C ;  Faculty of Medicine and Health Science, Department of Hematology, Cliniques universitaires Saint-Lu, Université catholique de Louvain (UCLouvain), Brussels, Belgium
Bartiaux, M;  Faculty of Medicine and Health Science, Department of Urgent Medicine, Hospital Saint-Pierre, Brussels, Belgium
Haerynck, F ;  Faculty of Medicine and Health Science, Department of Internal medicine and Paediatrics, Ghent University Hospital, Ghent, Belgium
Willekens, J;  Faculty of Medicine and Health Science, Department of Internal medicine and Paediatrics, Ghent University Hospital, Ghent, Belgium
Lapeere, H;  Faculty of Medicine and Health Science, Department of Dermatology, Ghent University Hospital, Ghent, Belgium
Moutschen, Michel  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des maladies infectieuses - médecine interne
Michel, O ;  Faculty of Medicine, Department of Immunology and Allergology, C.H.U. Brugmann, Brussels, Belgium
Sabato, V ;  Faculty of Medicine and Health Science, Department of Immunology - Allergology - Rheumatology, Antwerp University Hospital and the Infla-Med Center of Excellence, University of Antwerp, Antwerp, Belgium
Language :
English
Title :
Clinical practice of hereditary angioedema in Belgium: opportunities for optimized care.
Publication date :
December 2023
Journal title :
Acta Clinica Belgica
ISSN :
1784-3286
eISSN :
2295-3337
Publisher :
Taylor and Francis Ltd., England
Volume :
78
Issue :
6
Pages :
431 - 437
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
FWO - Fonds Wetenschappelijk Onderzoek Vlaanderen [BE]
Funding text :
Rik Schrijvers, Didier Ebo and Vito Sabato are supported by the Fonds Wetenschappelijk Onderzoek - Vlaanderen National Fund for Scientific Research (FWO) senior clinical investigator fellowship (Project numbers 1805518N, 1804518N and 1800614N respectively). The authors have nothing else to declare. The authors have no competing interests.
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