Thromboxanes; Thromboxane A2; Calcium; Calcium/metabolism; Chemical Phenomena; Chemistry, Physical; Molecular Conformation; Stereoisomerism; Thromboxane A2/metabolism; Thromboxanes/metabolism; X-Ray Diffraction; Pathology and Forensic Medicine; Toxicology; Pharmacology; Pharmacology, Toxicology and Pharmaceutics (all)
Abstract :
[en] Thromboxane A2 has been proposed as an ionophore capable to transport calcium from the platelet dense tubular system to the cytoplasm to activate the contractile proteins. However the half-life (30 sec.) of this compound limits considerably the experimental approach. The conformational analysis is proposed here as a possible way to identify such transient conformations. We bring evidence of the existence of two Ca2+-thromboxane A2 isomeric complexes: one structure responsible for the complexation-decomplexation process at the interface and one lipophilic structure able to cross the lipid membrane.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Brasseur, Robert ; ULB - Université Libre de Bruxelles [BE] > Laboratoire de chimie physique des macromolécules aux interfaces
Ruysschaert, Jean-Marie; ULB - Université Libre de Bruxelles [BE] > Laboratoire de chimie physique des macromolécules aux interfaces
Language :
English
Title :
Evidence of a thromboxane A2-Ca2+ complex: a conformational approach.
Publication date :
November 1984
Journal title :
Research Communications in Chemical Pathology and Pharmacology
