Theoretical study on conformation-related activity of hypoglycemic sulfonylureas.

Hypoglycemic Agents; Sulfonylurea Compounds; Hypoglycemic Agents/pharmacology; Molecular Conformation; Structure-Activity Relationship; Sulfonylurea Compounds/pharmacology; Pharmacology

Abstract :

[en] Theoretical conformational analysis has been carried out for different hypoglycemic sulfonylurea -Ca complexes. The formed complex has an hydrophobic external surface and a low amphiphilic character. Our results suggest that Calcium may effectively be transported across membranes of Langerhans B cells and that the different biological potencies of the drugs may be due in part to the shape of the different complexes.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Brasseur, Robert ; Laboratories of Macromolecules, Faculty of Sciences, Brussels Free University, Belgium

Deleers, M; Laboratories of Macromolecules at Interfaces and Experimental Medicine, Faculty of Sciences, School of Medicine, 1050 Brussels, Belgium

Language :

English

Title :

Theoretical study on conformation-related activity of hypoglycemic sulfonylureas.

Publication date :

November 1983

Journal title :

Pharmacological Research Communications

ISSN :

0031-6989

Publisher :

Elsevier BV, United States

Volume :

Issue :

Pages :

901 - 907

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:S0031698983800204?httpAccept=text/xml

Available on ORBi :

since 08 February 2024

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Bibliography

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