[en] We demonstrate how the progressive passage through an interface simulated by a linear increase in dielectric constant may mediate a reversible transconformation of Na+/X537A (lasalocid A) from a cyclic to an extended structure. During the passage through the interface, the complex adopts progressively a more extended conformation favorable to the Na+ complexation or decomplexation at the interface.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Brasseur, Robert ; Laboratoire de Chimie Physique des Macromolecules aux Interfaces, et Laboratoire de Medecine, CP 206/2, Université Libre de Bruxelles, Bruxelles, 1050, Belgium
Deleers, Michel; Laboratoire de Chimie Physique des Macromolecules aux Interfaces, et Laboratoire de Medecine, CP 206/2, Université Libre de Bruxelles, Bruxelles, 1050, Belgium
Ruysschaert, Jean-Marie; Laboratoire de Chimie Physique des Macromolecules aux Interfaces, et Laboratoire de Medecine, CP 206/2, Université Libre de Bruxelles, Bruxelles, 1050, Belgium
Language :
English
Title :
Sequence of ionophore conformational changes induced by a simulated membrane/water interface.
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