Article (Scientific journals)
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors.
Alexander, Stephen P H; Christopoulos, Arthur; Davenport, Anthony P et al.
2023In British Journal of Pharmacology, 180 Suppl 2 (S2), p. 23 - S144
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Keywords :
Receptors, G-Protein-Coupled; Ligands; Ion Channels; Receptors, Cytoplasmic and Nuclear; Humans; Ion Channels/chemistry; Databases, Pharmaceutical; Pharmacology
Abstract :
[en] The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.16177. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
Precision for document type :
Review article
Disciplines :
Pharmacy, pharmacology & toxicology
Biochemistry, biophysics & molecular biology
Author, co-author :
Alexander, Stephen P H ;  School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK
Christopoulos, Arthur ;  Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, 3052, Australia
Davenport, Anthony P ;  Clinical Pharmacology Unit, University of Cambridge, Cambridge, CB2 0QQ, UK
Kelly, Eamonn;  School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, UK
Mathie, Alistair A ;  School of Engineering, Arts, Science and Technology, University of Suffolk, Ipswich, IP4 1QJ, UK
Peters, John A ;  Neuroscience Division, Medical Education Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK
Veale, Emma L ;  Medway School of Pharmacy, The Universities of Greenwich and Kent at Medway, Anson Building, Central Avenue, Chatham Maritime, Chatham, Kent, ME4 4TB, UK
Armstrong, Jane F ;  Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, EH8 9XD, UK
Faccenda, Elena ;  Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, EH8 9XD, UK
Harding, Simon D ;  Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, EH8 9XD, UK
Davies, Jamie A ;  Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, EH8 9XD, UK
Abbracchio, Maria Pia ;  University of Milan, Milan, Italy
Abraham, George;  Clinical Pharmacology Unit, University of Cambridge, Cambridge, CB2 0QQ, UK
Agoulnik, Alexander;  Florida International University, Miami, USA
Alexander, Wayne;  Emory University, Atlanta, USA
Al-Hosaini, Khaled;  King Saud University, Riyadh, Kingdom of Saudi Arabia
Bäck, Magnus ;  Karolinska University Hospital, Stockholm, Sweden
Baker, Jillian G;  School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK
Barnes, Nicholas M;  University of Birmingham, Birmingham, UK
Bathgate, Ross ;  Florey Institute of Neuroscience and Mental Health, Melbourne, Australia
Beaulieu, Jean-Martin ;  University of Toronto, Toronto, Canada
Beck-Sickinger, Annette G ;  Leipzig University, Leipzig, Germany
Behrens, Maik ;  Technical University of Munich, Freising, Germany
Bernstein, Kenneth E ;  Cedars-Sinai Medical Center, Los Angeles, USA
Bettler, Bernhard ;  University of Basel, Basel, Switzerland
Birdsall, Nigel J M;  The Francis Crick Institute, London, UK
Blaho, Victoria ;  Sanford Burnham Prebys Medical Discovery Institute, La Jolla, USA
Boulay, Francois;  University of Grenoble Alpes, Grenoble, France
Bousquet, Corinne ;  French Institute of Health and Medical Research (INSERM), Toulouse, France
Bräuner-Osborne, Hans ;  University of Copenhagen, Copenhagen, Denmark
Burnstock, Geoffrey ;  University College London, London, UK
Caló, Girolamo;  University of Padova, Padova, Italy
Castaño, Justo P;  University of Córdoba, Córdoba, Spain
Catt, Kevin J;  National Institute of Health, Bethesda, USA
Ceruti, Stefania ;  University of Milan, Milan, Italy
Chazot, Paul ;  Durham University, Durham, UK
Chiang, Nan ;  Harvard University, Boston, USA
Chini, Bice ;  University of Milan Bicocca, Vedano al Lambro, Italy
Chun, Jerold ;  University of California San Diego, La Jolla, USA
Cianciulli, Antonia;  University of Bari, Bari, Italy
Civelli, Olivier;  University of California Irvine, Irvine, USA
Clapp, Lucie H ;  University College London, London, UK
Couture, Réjean;  University of Montréal, Montréal, Canada
Cox, Helen M ;  King's College London, London, UK
Csaba, Zsolt;  French Institute of Health and Medical Research (INSERM), Paris, France
Dahlgren, Claes;  University of Gothenburg, Gothenburg, Sweden
Dent, Gordon ;  Keele University, Keele, UK
Douglas, Steven D;  University of Pennsylvania, Pennsylvania, USA
Dournaud, Pascal;  French Institute of Health and Medical Research (INSERM), Paris, France
Eguchi, Satoru;  Temple University, Philadelphia, USA
Escher, Emanuel;  University of Sherbrooke, Sherbrooke, Canada
Filardo, Edward J;  University of Iowa, Iowa City, USA
Fong, Tung;  Labcorp Drug Development, Somerset, USA
Fumagalli, Marta ;  University of Milan, Milan, Italy
Gainetdinov, Raul R ;  Saint Petersburg State University, Saint-Petersburg, Russia
Garelja, Michael L ;  University of Otago, Dunedin, New Zealand
de Gasparo, Marc;  MG Consulting Co, Basel, Switzerland
Gerard, Craig;  Harvard University, Boston, USA
Gershengorn, Marvin;  National Institute of Health, Bethesda, USA
Gobeil, Fernand;  University of Sherbrooke, Sherbrooke, Canada
Goodfriend, Theodore L;  University of Wisconsin, Madison, USA
Goudet, Cyril ;  French National Centre for Scientific Research, Montpellier, France
Grätz, Lukas;  Karolinska Institute, Stockholm, Sweden
Gregory, Karen J ;  Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, 3052, Australia
Gundlach, Andrew L ;  Florey Institute of Neuroscience and Mental Health, Melbourne, Australia
Hamann, Jörg ;  Amsterdam University, Amsterdam, The Netherlands
Hanson, Julien  ;  Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique
Hauger, Richard L;  University of California San Diego, La Jolla, USA
Hay, Debbie L ;  University of Otago, Dunedin, New Zealand
Heinemann, Akos ;  Medical University of Graz, Graz, Austria
Herr, Deron ;  San Diego State University, San Diego, USA
Hollenberg, Morley D;  University of Calgary, Calgary, Canada
Holliday, Nicholas D ;  School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK
Horiuchi, Mastgugu;  Ehime University, Ehime, Japan
Hoyer, Daniel ;  University of Melbourne, Melbourne, Australia
Hunyady, László;  Semmelweis University, Budapest, Hungary
Husain, Ahsan;  Emory University, Atlanta, USA
IJzerman, Adriaan P ;  Leiden University, Leiden, The Netherlands
Inagami, Tadashi;  Vanderbilt University, Nashville, USA
Jacobson, Kenneth A ;  National Institute of Health, Bethesda, USA
Jensen, Robert T;  National Institute of Health, Bethesda, USA
Jockers, Ralf ;  French Institute of Health and Medical Research (INSERM), Paris, France
Jonnalagadda, Deepa ;  Sanford Burnham Prebys Medical Discovery Institute, La Jolla, USA
Karnik, Sadashiva ;  Lerner Research Institute, Cleveland, USA
Kaupmann, Klemens ;  Novartis, Basel, Switzerland
Kemp, Jacqueline;  Cleveland Clinic Lerner Research Institute, Cleveland, USA
Kennedy, Charles ;  Strathclyde University, Glasgow, UK
Kihara, Yasuyuki ;  Sanford Burnham Prebys Medical Discovery Institute, La Jolla, USA
Kitazawa, Takio;  Rakuno Gakuen University, Ebetsu, Japan
Kozielewicz, Pawel ;  Karolinska Institute, Stockholm, Sweden
Kreienkamp, Hans-Jürgen;  University of Hamburg, Hamburg, Germany
Kukkonen, Jyrki P ;  University of Helsinki, Helsinki, Finland
Langenhan, Tobias ;  Leipzig University, Leipzig, Germany
Larhammar, Dan ;  Uppsala University, Uppsala, Sweden
Leach, Katie ;  Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, 3052, Australia
Lecca, Davide ;  University of Milan, Milan, Italy
Lee, John D ;  University of Queensland, Brisbane, Australia
Leeman, Susan E;  Boston University, Boston, USA
Leprince, Jérôme ;  University of Rouen, Rouen, France
Li, Xaria X ;  University of Queensland, Queensland, Australia
Lolait, Stephen J ;  School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, UK
Lupp, Amelie;  Friedrich Schiller University Jena, Jena, Germany
Macrae, Robyn;  University of Cambridge, Cambridge, UK
Maguire, Janet ;  Clinical Pharmacology Unit, University of Cambridge, Cambridge, CB2 0QQ, UK
Malfacini, Davide;  University of Padova, Padova, Italy
Mazella, Jean ;  French National Centre for Scientific Research (CNRS), Valbonne, France
McArdle, Craig A ;  School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, UK
Melmed, Shlomo;  Cedars-Sinai Medical Center, Los Angeles, USA
Michel, Martin C ;  Johannes Gutenberg University Mainz, Mainz, Germany
Miller, Laurence J ;  Mayo Foundation for Medical Education and Research, Scottsdale, USA
Mitolo, Vincenzo;  University of Bari, Bari, Italy
Mouillac, Bernard ;  French National Centre for Scientific Research, Montpellier, France
Müller, Christa E ;  University of Bonn, Bonn, Germany
Murphy, Philip M;  Edge Hill University, Bethesda, USA
Nahon, Jean-Louis ;  French National Centre for Scientific Research (CNRS), Valbonne, France
Ngo, Tony ;  Sanford Burnham Prebys Medical Discovery Institute, La Jolla, USA
Norel, Xavier ;  French Institute of Health and Medical Research (INSERM), Paris, France
Nyimanu, Duuamene;  University of Cambridge, Cambridge, UK
O'Carroll, Anne-Marie ;  School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, UK
Offermanns, Stefan ;  Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
Panaro, Maria Antonietta;  University of Bari, Bari, Italy
Parmentier, Marc;  Free University of Brussels, Brussels, Belgium
Pertwee, Roger G ;  University of Aberdeen, Aberdeen, UK
Pin, Jean-Philippe ;  University of Montpellier, Montpellier, France
Prossnitz, Eric R ;  University of New Mexico, Albuquerque, USA
Quinn, Mark;  Montana State University, Bozeman, USA
Ramachandran, Rithwik ;  University of Calgary, Calgary, Canada
Ray, Manisha ;  Sanford Burnham Prebys Medical Discovery Institute, La Jolla, USA
Reinscheid, Rainer K;  Friedrich Schiller University Jena, Jena, Germany
Rondard, Philippe ;  University of Montpellier, Montpellier, France
Rovati, G Enrico ;  University of Milan, Milan, Italy
Ruzza, Chiara ;  University of Ferrara, Ferrara, Italy
Sanger, Gareth J ;  Queen Mary University of London, London, UK
Schöneberg, Torsten ;  Leipzig University, Leipzig, Germany
Schulte, Gunnar ;  Karolinska Institute, Stockholm, Sweden
Schulz, Stefan;  Friedrich Schiller University Jena, Jena, Germany
Segaloff, Deborah L;  University of Iowa, Iowa City, USA
Serhan, Charles N;  Harvard University, Boston, USA
Singh, Khuraijam Dhanachandra ;  Cleveland Clinic Lerner Research Institute, Cleveland, USA
Smith, Craig M;  Deakin University, Waurn Ponds, Australia
Stoddart, Leigh A ;  School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK
Sugimoto, Yukihiko ;  Kumamoto University, Kumamoto, Japan
Summers, Roger ;  Monash University, Melbourne, Australia
Tan, Valerie P ;  University of California San Diego, La Jolla, USA
Thal, David ;  Monash University, Melbourne, Australia
Thomas, Walter Wally;  University of Queensland, Queensland, Australia
Timmermans, Pieter B M W M;  Kosan Biosciences Inc., San Francisco, USA
Tirupula, Kalyan;  Cleveland Clinic Lerner Research Institute, Cleveland, USA
Toll, Lawrence ;  Florida Atlantic University, Jupiter, USA
Tulipano, Giovanni;  University of Brescia, Brescia, Italy
Unal, Hamiyet;  Cleveland Clinic, Cleveland, USA
Unger, Thomas;  Maastricht University, Maastricht, The Netherlands
Valant, Celine ;  Monash University, Melbourne, Australia
Vanderheyden, Patrick;  Free University of Brussels, Brussels, Belgium
Vaudry, David;  University of Rouen, Rouen, France
Vaudry, Hubert;  University of Rouen, Rouen, France
Vilardaga, Jean-Pierre;  University of Pittsburgh, Pittsburgh, USA
Walker, Christopher S ;  University of Auckland, Auckland, New Zealand
Wang, Ji Ming;  National Institute of Health, Frederick, USA
Ward, Donald T ;  University of Manchester, Manchester, UK
Wester, Hans-Jürgen;  Technical University of Munich, Munich, Germany
Willars, Gary B;  University of Leicester, Leicester, UK
Williams, Tom Lloyd;  University of Cambridge, Cambridge, UK
Woodruff, Trent M ;  University of Queensland, Queensland, Australia
Yao, Chengcan ;  University of Edinburgh, Edinburgh, UK
Ye, Richard D;  The Chinese University of Hong Kong, Shenzhen, China
More authors (156 more) Less
Language :
English
Title :
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors.
Publication date :
October 2023
Journal title :
British Journal of Pharmacology
ISSN :
0007-1188
Publisher :
John Wiley and Sons Inc, England
Volume :
180 Suppl 2
Issue :
S2
Pages :
S23 - S144
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 01 February 2024

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