3 Manley, Q.W.; Quast, U. J. Med. Chem. 1992, 35, 2327-2340
4 Takemoto, T.; Eda, M.; Okada, T.; Sakashita, H.; Matzno, S.; Gohda, M.; Ebisu, H.; Nakamura, M.; Fukaya, C.; Hihara, M.; Eikaku, M.; Yamanoushi, K.; Yokoyama, K. J. Med. Chem. 1994, 37, 18-25
5 Arndt, F.; Martius, C. Justus Liebigs Ann. Chem. 1932, 499, 228-287
6 Weber, H.; Aumüller, W.; Muth, K.; Weyer, R.; Heerdt, R.; Fauland, E.; Bänder, A.; Pfaff, W.; Schmidt, F.H.; Stork, H. Drug Research / Arz. Forschung 1969, 19, 1326-1346
7 Hantzsch, A.; Wolvekamp, M. Justus Liebigs Ann. Chem. 1904, 331, 264-297
8 Marchetti P.; Navalesi, R. Clinical Pharmacokinetics 1989, 16, 100-128
9 The elemental analyses for C,H,N,S are within 0.4% of the theorical values and were performed on a Carlo Erba 1108 analyzer. All new compounds gave IR and 1H-NMR spectra in accordance with their proposed structure. 7: 1H-NMR (80 MHz, d6-DMSO) δ 7.65 (2H, d, J=8Hz), 7.30 (2H, d, J=8Hz), 5.60 (2H, m), 3.15 (2H, br s), 2.30 (3H, s), 1.65-1.25 (4H, m), 0.8 (3H, t). IR (KBr) 2199 cm-1 (C≡N st). 16: 1H-NMR (80 MHz, d6-DMSO) δ 8.18 (1H, m), 7.75 (2H, d), 7.58 (1H, d), 7.4 (3H, dd), 7.05 (1H, d), 4.70 (2H, br s), 3.72 (3H, s), 3.25-3.65 (3H, m), 2.95 (2H, m), 1.80-0.95 (10H, m). IR (KBr) 2188 cm-1 (C≡N st).
10 Häussler, A.; Hajdù, P. Arch. Pharm. 1958, 291, 531-535
11 Hajdù, P.; Kohler, K.F.; Schmidt, F.M.; Spingler, H. Drug Research/ Arz. Forschung 1969, 19, 1381-1386
