Article (Scientific journals)
The uptake of [18F]-fluorodeoxyglucose by the renal allograft correlates with the acute Banff scores of cortex inflammation but not with the 1-year graft outcomes
Fank, Hélène; Weekers, Laurent; Lovinfosse, Pierre et al.
2023In Frontiers in Transplantation, 2
Peer reviewed
 

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Keywords :
[18F]FDG PET-CT; Kidney Transplantation; Biopsy proven acute rejection
Abstract :
[en] Introduction[18F]FDG PET/CT noninvasively disproves acute kidney allograft rejection (AR) in kidney transplant recipients (KTRs) with suspected AR. However, the correlation of biopsy-based Banff vs. PET/CT-based scores of acute inflammation remains unknown, as does the prognostic performance of [18F]FDG PET/CT at one year post suspected AR.MethodsFrom 2012 to 2019, 114 [18F]FDG-PET/CTs were prospectively performed in 105 adult KTRs who underwent per cause transplant biopsies. Ordinal logistic regression assessed the correlation between the extent of histological inflammation and the mean standardized [18F]FDG uptake values (mSUVmean). Functional outcomes of kidney allografts were evaluated at one year post per cause biopsy and correlated to mSUVmean.ResultsA significant correlation between mSUVmean and acute Banff score was found, with an adjusted R2 of 0.25. The mSUVmean was significantly different between subgroups of “total i”, with 2.30 ± 0.71 in score 3 vs. 1.68 ± 0.24 in score 0. Neither the function nor the survival of the graft at one year was statistically related to mSUVmean.Discussion[18F]FDG-PET/CT may help noninvasively assess the severity of kidney allograft inflammation in KTRs with suspected AR, but it does not predict graft outcomes at one year.
Disciplines :
Urology & nephrology
Author, co-author :
Fank, Hélène  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de néphrologie
Weekers, Laurent   ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de néphrologie
Lovinfosse, Pierre  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service médical de médecine nucléaire et imagerie onco
Pottel, Hans ;  Université de Liège - ULiège > Département des sciences cliniques
Seidel, Laurence  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des informations médico économiques (SIME)
Jadoul, Alexandre ;  Centre Hospitalier Universitaire de Liège - CHU > > Service médical de médecine nucléaire et imagerie onco
Bouquegneau, Antoine  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de néphrologie
BONVOISIN, Catherine ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de néphrologie
Bovy, Christophe ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de néphrologie
GROSCH, Stéphanie ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de néphrologie
Erpicum, Pauline ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de néphrologie
Hustinx, Roland  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service médical de médecine nucléaire et imagerie onco
Jouret, François  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de néphrologie
More authors (3 more) Less
 These authors have contributed equally to this work.
Language :
English
Title :
The uptake of [18F]-fluorodeoxyglucose by the renal allograft correlates with the acute Banff scores of cortex inflammation but not with the 1-year graft outcomes
Publication date :
25 August 2023
Journal title :
Frontiers in Transplantation
ISSN :
2813-2440
Publisher :
Frontiers Media SA
Volume :
2
Peer reviewed :
Peer reviewed
Funders :
CHU Liège - Central University Hospital of Liege [BE]
Funding text :
ULiège Academic Hospital (Fonds d’Investissement pour la Recherche Scientifique, FIRS)
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since 28 January 2024

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