The effect of organ preservation solutions on short-term outcomes after liver transplantation: a single-center retrospective study

Van den Eynde, Jef; Achtergaele, Jannick; Fieuws, Steffen; Jochmans, Ina; Sainz-Barriga, Mauricio; Monbaliu, Diethard; Pirenne, Jacques; Gilbo, NICHOLAS

doi:10.1111/tri.13799

Article (Scientific journals)

The effect of organ preservation solutions on short-term outcomes after liver transplantation: a single-center retrospective study

Van den Eynde, Jef; Achtergaele, Jannick; Fieuws, Steffen et al.

2021 • In Transplant International, 34 (2), p. 327 - 338

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https://hdl.handle.net/2268/311960

DOI
10.1111/tri.13799

PubMed
33280170

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Keywords :

Histidine–Tryptophan–Ketoglutarate; IGL-1; liver transplantation; preservation solutions; University of Wisconsin; Adenosine; Glucose; Glutathione; Graft Survival; Humans; Insulin; Liver; Liver Transplantation; Mannitol; Organ Preservation; Organ Preservation Solutions; Potassium Chloride; Raffinose; Retrospective Studies; aspartate aminotransferase; HTK solution; Institute George Lopez 1 preservation solution; preservation solution; unclassified drug; University of Wisconsin solution; adenosine; glucose; glutathione; insulin; mannitol; potassium chloride; raffinose; adult; aged; allograft; Article; cholestasis; comparative study; controlled study; female; graft dysfunction; graft recipient; graft survival; human; liver injury; major clinical study; male; priority journal; retrospective study; treatment outcome; liver; organ preservation

Abstract :

[en] The effect of preservation solutions on outcomes has been subject of many debates but the relative benefits of the various solutions remain unclear. We retrospectively compared short-term outcomes of 885 liver transplantations performed between 1/2000 and 12/2017 and preserved with either Histidine–Tryptophan–Ketoglutarate (HTK, n = 190), University of Wisconsin (UW, n = 557), or Institute George Lopez 1 preservation solution (IGL-1, n = 139). Inverse probability of treatment weighting (IPTW) was performed to account for baseline differences between groups and analyses were adjusted for confounders. In the IPTW analyses, peak AST within 7 days was 44% higher (95% CI 15–81%, P < 0.001) in HTK than in UW. Mean model of early allograft function (MEAF) score was 0.61 points (95% CI 0.12–1.10, P = 0.01) higher in HTK than in UW. Early allograft dysfunction (EAD) was more likely to occur with HTK compared to IGL-1 (IPTW OR = 2.87, 95% CI = 1.00–8.19, P = 0.049) and UW (IPTW OR = 1.75, 95% CI = 1.06–2.88, P = 0.023). The type of preservation solution had no impact on hospital stay, ICU stay, incidence of biliary strictures, or graft and recipient survival. HTK was the least effective on reducing graft injury and increased the probability of graft dysfunction after transplantation. UW and IGL-1 were equally effective in reducing graft injury and dysfunction. © 2020 Steunstichting ESOT. Published by John Wiley & Sons Ltd.

Disciplines :

Surgery

Author, co-author :

Van den Eynde, Jef; Department of Abdominal Transplantation Surgery, University Hospitals Leuven, Leuven, Belgium ; Laboratory of Abdominal Transplant Surgery, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium

Achtergaele, Jannick; Department of Abdominal Transplantation Surgery, University Hospitals Leuven, Leuven, Belgium ; Laboratory of Abdominal Transplant Surgery, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium

Fieuws, Steffen; Leuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat), KU Leuven, Leuven, Belgium

Jochmans, Ina; Department of Abdominal Transplantation Surgery, University Hospitals Leuven, Leuven, Belgium ; Laboratory of Abdominal Transplant Surgery, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium

Sainz-Barriga, Mauricio; Department of Abdominal Transplantation Surgery, University Hospitals Leuven, Leuven, Belgium ; Laboratory of Abdominal Transplant Surgery, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium

Monbaliu, Diethard; Department of Abdominal Transplantation Surgery, University Hospitals Leuven, Leuven, Belgium ; Laboratory of Abdominal Transplant Surgery, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium

Pirenne, Jacques; Department of Abdominal Transplantation Surgery, University Hospitals Leuven, Leuven, Belgium ; Laboratory of Abdominal Transplant Surgery, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium

Gilbo, NICHOLAS ; Université de Liège - ULiège > Département des sciences cliniques > Pathologie chirurgicale abdominale et endocrinienne ; Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie abdo, sénologique, endocrine et de transplantation

Language :

English

Title :

The effect of organ preservation solutions on short-term outcomes after liver transplantation: a single-center retrospective study

Publication date :

2021

Journal title :

Transplant International

ISSN :

0934-0874

eISSN :

1432-2277

Publisher :

Blackwell Publishing Ltd

Volume :

Issue :

Pages :

327 - 338

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 25 January 2024

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