Heart transplantation in adults with congenital heart disease: a 17-year single center experience.

Heart transplantation; adulthood; congenital heart disease; heart failure; paediatric; survival; Adult; Humans; Middle Aged; Retrospective Studies; Heart Transplantation; Heart Defects, Congenital/surgery; Heart Defects, Congenital; Cardiology and Cardiovascular Medicine; General Medicine

Abstract :

[en] [en] BACKGROUND: Heart transplantation (HTx) in adults with congenital heart disease (ACHD) remains challenging because of structural anomalies and often previous procedure. The aim of this retrospective study was to describe the outcomes of heart transplantation (HTx) in a cohort of ACHD patients at our tertiary centre. PATIENTS AND METHODS: Between January 1993 and December 2010, 223 consecutive adult patients (age > 18 years) underwent HTx at our institution. Fifteen (6.7%) were ACHD patients. Outcomes were reviewed using our institution's HTx database. We looked at 30-day, 1, 5 and 10-years survival, as well as post-transplantation complications. RESULTS: The mean age at HTx of the groups of ACHD was 42 ± 14.4 years, vs 54.2 ± 9.8 years for the non-CHD patients. Prior to transplant, thirteen of the fifteen ACHD had undergone one or more surgical procedures including palliative or corrective open-heart procedures in 66.6% of them. Seven of the fifteen ACHD (47%) required additional surgical procedures at transplantation. The mean follow-up was 95,44 ± 84.3 months. There was no significant difference in survival (ACHD vs non-CHD) at 30 days (87% vs. 90%), 1 year (73% vs. 74.5%) or 5 years (53% vs. 55%). Survival at 10 years was respectively 53% and 41% for ACHD patients and non-CHD patients. CONCLUSION: Despite the surgical challenge, HTx in ACHD has a good long-term result. However, the small sample size of our cohort limits any definitive conclusions.

Disciplines :

Cardiovascular & respiratory systems
Surgery

Author, co-author :

Brüls, Samuel ; Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie cardio-vasculaire et thoracique

Tchana-Sato, Vincent ; Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie cardio-vasculaire et thoracique

Ancion, Arnaud ; Centre Hospitalier Universitaire de Liège - CHU > > Service de cardiologie

DESIRON, Quentin ; Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie cardio-vasculaire et thoracique

LAVIGNE, Jean-Paul ; Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie cardio-vasculaire et thoracique

Defraigne, Jean-Olivier ; Université de Liège - ULiège > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique

Language :

English

Title :

Heart transplantation in adults with congenital heart disease: a 17-year single center experience.

Publication date :

April 2023

Journal title :

Acta Cardiologica

ISSN :

0001-5385

eISSN :

1784-973X

Publisher :

Taylor and Francis Ltd., England

Volume :

Issue :

Pages :

188 - 194

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://www.tandfonline.com/doi/pdf/10.1080/00015385.2021.1973773

Available on ORBi :

since 22 January 2024

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