Cartilaginous endplates: A comprehensive review on a neglected structure in intervertebral disc research

Crump, Katherine B.; Alminnawi, Ahmad; Bermudez-Lekerika, Paola; Compte, Roger; Gualdi, Francesco; McSweeney, Terence; Muñoz-Moya, Estefano; Nüesch, Andrea; Geris, Liesbet; Dudli, Stefan; Karppinen, Jaro; Noailly, Jérôme; Le Maitre, Christine; Gantenbein, Benjamin

doi:10.1002/jsp2.1294

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Cartilaginous endplates: A comprehensive review on a neglected structure in intervertebral disc research

Crump, Katherine B.; Alminnawi, Ahmad; Bermudez-Lekerika, Paola et al.

2023 • In JOR Spine

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https://hdl.handle.net/2268/311598

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10.1002/jsp2.1294

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Keywords :

biologic therapies; biomechanics; degeneration; pre-clinical models; Orthopedics and Sports Medicine

Abstract :

[en] The cartilaginous endplates (CEP) are key components of the intervertebral disc (IVD) necessary for sustaining the nutrition of the disc while distributing mechanical loads and preventing the disc from bulging into the adjacent vertebral body. The size, shape, and composition of the CEP are essential in maintaining its function, and degeneration of the CEP is considered a contributor to early IVD degeneration. In addition, the CEP is implicated in Modic changes, which are often associated with low back pain. This review aims to tackle the current knowledge of the CEP regarding its structure, composition, permeability, and mechanical role in a healthy disc, how they change with degeneration, and how they connect to IVD degeneration and low back pain. Additionally, the authors suggest a standardized naming convention regarding the CEP and bony endplate and suggest avoiding the term vertebral endplate. Currently, there is limited data on the CEP itself as reported data is often a combination of CEP and bony endplate, or the CEP is considered as articular cartilage. However, it is clear the CEP is a unique tissue type that differs from articular cartilage, bony endplate, and other IVD tissues. Thus, future research should investigate the CEP separately to fully understand its role in healthy and degenerated IVDs. Further, most IVD regeneration therapies in development failed to address, or even considered the CEP, despite its key role in nutrition and mechanical stability within the IVD. Thus, the CEP should be considered and potentially targeted for future sustainable treatments.

Disciplines :

Orthopedics, rehabilitation & sports medicine

Author, co-author :

Crump, Katherine B. ^✱; Tissue Engineering for Orthopaedics & Mechanobiology, Bone & Joint Program, Department for BioMedical Research (DBMR), Medical Faculty, University of Bern, Bern, Switzerland ; Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, Medical Faculty, University of Bern, Bern, Switzerland ; Graduate School for Cellular and Biomedical Sciences (GCB), University of Bern, Bern, Switzerland

Alminnawi, Ahmad ^✱; Université de Liège - ULiège > Aérospatiale et Mécanique (A&M) ; Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium ; Biomechanics Research Unit, KU Leuven, Leuven, Belgium

Bermudez-Lekerika, Paola ; Tissue Engineering for Orthopaedics & Mechanobiology, Bone & Joint Program, Department for BioMedical Research (DBMR), Medical Faculty, University of Bern, Bern, Switzerland ; Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, Medical Faculty, University of Bern, Bern, Switzerland ; Graduate School for Cellular and Biomedical Sciences (GCB), University of Bern, Bern, Switzerland

Compte, Roger ; Twin Research & Genetic Epidemiology, St. Thomas' Hospital, King's College London, London, United Kingdom

Gualdi, Francesco ; Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain

McSweeney, Terence ; Research Unit of Health Sciences and Technology, University of Oulu, Oulu, Finland

Muñoz-Moya, Estefano ; BCN MedTech, Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Spain

Nüesch, Andrea ; Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom

Geris, Liesbet ; Université de Liège - ULiège > Département d'aérospatiale et mécanique > Génie biomécanique ; Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium ; Biomechanics Research Unit, KU Leuven, Leuven, Belgium

Dudli, Stefan ; Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland ; Department of Physical Medicine and Rheumatology, Balgrist University Hospital, Balgrist Campus, University of Zurich, Zurich, Switzerland

More authors (4 more)

^✱ These authors have contributed equally to this work.

Language :

English

Title :

Cartilaginous endplates: A comprehensive review on a neglected structure in intervertebral disc research

Publication date :

21 October 2023

Journal title :

JOR Spine

eISSN :

2572-1143

Publisher :

John Wiley and Sons Inc

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jsp2.1294

European Projects :

H2020 - 955735 - Disc4All - Training network to advance integrated computational simulations in translational medicine, applied to intervertebral disc degeneration

Funders :

EU - European Union [BE]

Funding text :

This research review was financed by the Marie Skłodowska Curie International Training Network (ITN) “disc4all” ( https://disc4all.upf.edu , accessed on 3 September 2023) grant agreement #955735 ( https://cordis.europa.eu/project/id/955735 , accessed on 3 September 2023).

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