Article (Scientific journals)
How well does your E-nose detect cancer? Application of artificial breath analysis for performance assessment.
Martin, Justin; Falzone, Claudia; Romain, Anne-Claude
2024In Journal of Breath Research
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Keywords :
Benchmarking; Breath; Detection; Electronic nose; Lung cancer; Metal oxide; gas sensor; Pulmonary and Respiratory Medicine
Abstract :
[en] Comparing electronic nose performance is a challenging task because of a lack of standardised method. This paper proposes a method for defining and quantifying an indicator of the effectiveness of multi-sensor systems in detecting cancers by artificial breath analysis. To build this method, an evaluation of the performances of an array of metal oxide sensors built for use as a lung cancer screening tool was conducted. Breath from 20 healthy volunteers has been sampled in FEP sampling bags. These healthy samples were analysed with and without the addition of 9 VOC cancer biomarkers, chosen from literature. The concentration of the VOC added was done in increasing amounts. The more VOC were added, the better the discrimination between "healthy" samples (breath without additives) and "cancer" samples (breath with additives) was. By determining at which level of concentration the electronic nose fails to reliably discriminate between the two groups, we estimate its ability to well predict the presence of the disease or not in a realistic situation. In this work, a home-made electronic nose is put to the test. The results underline that the biomarkers need to be about 5.3 times higher in concentration than in real breath for the home-made nose to tell the difference between groups with a sufficient confidence.
Disciplines :
Human health sciences: Multidisciplinary, general & others
Physical, chemical, mathematical & earth Sciences: Multidisciplinary, general & others
Engineering, computing & technology: Multidisciplinary, general & others
Author, co-author :
Martin, Justin  ;  Université de Liège - ULiège > Sphères
Falzone, Claudia  ;  Université de Liège - ULiège > Sphères
Romain, Anne-Claude  ;  Université de Liège - ULiège > Département des sciences et gestion de l'environnement (Arlon Campus Environnement) > Surveillance de l'environnement
Language :
English
Title :
How well does your E-nose detect cancer? Application of artificial breath analysis for performance assessment.
Publication date :
11 January 2024
Journal title :
Journal of Breath Research
ISSN :
1752-7155
eISSN :
1752-7163
Publisher :
IOP Publishing, England
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
Pathacov
Funders :
Interreg France-Wallonie-Vlaanderen
UR Spheres
Available on ORBi :
since 18 January 2024

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