Article (Scientific journals)
The Endometrial Microbiota: Challenges and Prospects.
Kaluanga Bwanga, Pauline; TREMBLAY LEMOINE, Pierre Luc; Timmermans, Marie et al.
2023In Medicina, 59 (9), p. 1540
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Keywords :
chronic endometritis; endometrial microbiota; endometriosis; fertility; microbiome; oncology; reproductive outcomes; uterus; Female; Humans; Uterus; Carcinogenesis; Inflammation; Lactobacillus; Endometrium; Microbiota; Medicine (all); General Medicine
Abstract :
[en] Contrary to popular belief, we have known for many years that the endometrium is not a sterile environment and is considered to be a low-biomass milieu compared to the vagina. Numerous trials and studies have attempted to establish a valid sampling method and assess its physiological composition, but no consensus has been reached. Many factors, such as ethnicity, age and inflammation, can influence the microbiome. Moreover, it possesses a higher alpha-diversity and, therefore, contains more diverse bacteria than the vagina. For instance, Lactobacillus has been shown to be a predominant genus in the vaginal microbiome of healthy women. Consequently, even if a majority of scientists postulate that a predominance of Lactobacillus inside the uterus improves reproductive outcomes, vaginal contamination by these bacteria during sampling cannot be ruled out. Certain pathologies, such as chronic endometritis, have been identified as inflammation perpetrators that hinder the embryo implantation process. This pro-inflammatory climate created by dysbiosis of the endometrial microbiota could induce secondary inflammatory mediators via Toll-like receptors, creating an environment conducive to the development of endometriosis and even promoting carcinogenesis. However, studies to this day have focused on small populations. In addition, there is no clearly defined healthy uterine composition yet. At most, only a few taxa have been identified as pathogenic. As sampling and analysis methods become increasingly precise, we can expect the endometrial microbiota to be incorporated into future diagnostic tools and treatments for women's health.
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
Kaluanga Bwanga, Pauline ;  Faculty of Medicine, University of Liège, 4000 Liège, Belgium
TREMBLAY LEMOINE, Pierre Luc ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de gynécologie-obstétrique
Timmermans, Marie ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de gynécologie-obstétrique (CHR)
RAVET, Stéphanie ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de gynécologie-obstétrique (CHR)
Munaut, Carine  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques
Nisolle, Michelle ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Henry, Laurie  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de gynécologie-obstétrique (CHR)
Language :
English
Title :
The Endometrial Microbiota: Challenges and Prospects.
Publication date :
25 August 2023
Journal title :
Medicina
ISSN :
1010-660X
eISSN :
1648-9144
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Switzerland
Volume :
59
Issue :
9
Pages :
1540
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 13 January 2024

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