Article (Scientific journals)
Preoperative continuation of aspirin before isolated heart valve surgery and postoperative bleeding and transfusion: a single-center retrospective study.
Houben, Alan; Crepy, Margaux; Senard, Marc et al.
2023In Acta Chirurgica Belgica, p. 1 - 7
Peer reviewed
 

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Keywords :
Aspirin; bleeding; transfusion; valve surgery; General Medicine; Surgery
Abstract :
[en] [en] BACKGROUND: The risks and benefits of preoperative aspirin continuation in patients undergoing isolated heart valve replacement surgery are unclear. We investigated the effect of aspirin continuation on the risk of bleeding and transfusion in these patients. METHODS: In this single center, retrospective study, among 474 adult patients who underwent isolated heart valve surgery between April 2013 and June 2018, 269 continued aspirin within 5 days before surgery (aspirin group) and 205 patients did not take or stopped aspirin no later than 5 days before surgery (non-aspirin group). The chi-square test, the Mann-Whitney U-test, and the Student's T-test were used to compare data between the groups. Univariate and Multivariate logistic regressions were used to assess crude and adjusted relationships between outcome and exposure. RESULTS: The primary outcome, red blood cell (RBC) transfusion, occurred in 59 patients (22%) of the aspirin group and in 24 patients (12%) of the non-aspirin group (p = 0.004). After adjustment for confounding factors, continuation of aspirin was no longer associated with RBC transfusion (aOR1.8;95%CI,0.98-3.2;p = 0.06). The amount of allogenic blood products, the incidence of surgical re-exploration for bleeding, the volume of re-transfused cell-saved blood, and the cumulative chest tube drainage during the first 24 postoperative hours were similar between groups. CONCLUSION: Preoperative continuation of aspirin in patients undergoing isolated heart valve surgery is neither associated with a higher incidence of RBC transfusion, nor with larger perioperative blood loss, or more frequent surgical revision for bleeding. TRIAL REGISTRATION: Clinicaltrials.gov (NCT05151796).
Disciplines :
Anesthesia & intensive care
Author, co-author :
Houben, Alan ;  Centre Hospitalier Universitaire de Liège - CHU > > Service d'anesthésie - réanimation
Crepy, Margaux;  Department of Anesthesia and Intensive Care Medicine, Liege University Hospital, Liege, Belgium
Senard, Marc ;  Centre Hospitalier Universitaire de Liège - CHU > > Service d'anesthésie - réanimation
Bonhomme, Vincent  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service d'anesthésie - réanimation
Tchana-Sato, Vincent  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie cardio-vasculaire et thoracique
Hans, Grégory ;  Centre Hospitalier Universitaire de Liège - CHU > > Service d'anesthésie - réanimation
Language :
English
Title :
Preoperative continuation of aspirin before isolated heart valve surgery and postoperative bleeding and transfusion: a single-center retrospective study.
Publication date :
26 December 2023
Journal title :
Acta Chirurgica Belgica
ISSN :
0001-5458
Publisher :
Informa UK Limited, England
Pages :
1 - 7
Peer reviewed :
Peer reviewed
Available on ORBi :
since 29 December 2023

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