Article (Scientific journals)
In vivo marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men.
Talwar, Puneet; Deantoni, Michele; Van Egroo, Maxime et al.
2023In Scientific Reports, 13 (1), p. 20873
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Keywords :
Male; Humans; Adult; Aged; Sleep/physiology; Brain/physiology; Aging; Magnetic Resonance Imaging/methods; Myelin Sheath; Brain Stem/diagnostic imaging; Multidisciplinary
Abstract :
[en] The regional integrity of brain subcortical structures has been implicated in sleep-wake regulation, however, their associations with sleep parameters remain largely unexplored. Here, we assessed association between quantitative Magnetic Resonance Imaging (qMRI)-derived marker of the myelin content of the brainstem and the variability in the sleep electrophysiology in a large sample of 18-to-31 years healthy young men (N = 321; ~ 22 years). Separate Generalized Additive Model for Location, Scale and Shape (GAMLSS) revealed that sleep onset latency and slow wave energy were significantly associated with MTsat estimates in the brainstem (pcorrected ≤ 0.03), with overall higher MTsat value associated with values reflecting better sleep quality. The association changed with age, however (MTsat-by-age interaction-pcorrected ≤ 0.03), with higher MTsat value linked to better values in the two sleep metrics in the younger individuals of our sample aged ~ 18 to 20 years. Similar associations were detected across different parts of the brainstem (pcorrected ≤ 0.03), suggesting that the overall maturation and integrity of the brainstem was associated with both sleep metrics. Our results suggest that myelination of the brainstem nuclei essential to regulation of sleep is associated with inter-individual differences in sleep characteristics during early adulthood. They may have implications for sleep disorders or neurological diseases related to myelin.
Disciplines :
Human health sciences: Multidisciplinary, general & others
Author, co-author :
Talwar, Puneet ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Deantoni, Michele ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Van Egroo, Maxime;  GIGA-Institute, CRC-In Vivo Imaging Unit, Bâtiment B30, Université de Liège, 4000, Liège, Belgium ; Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, The Netherlands
Muto, Vincenzo  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology ; Walloon Excellence in Life Sciences and Biotechnology (WELBIO), Wallonia, Belgium
Chylinski, Daphné ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Koshmanova, Ekaterina ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Jaspar, Mathieu ;  Université de Liège - ULiège > Unités de recherche interfacultaires > GIGA-CRC In vivo Imaging (Centre de Recherche du Cyclotron) ; Walloon Excellence in Life Sciences and Biotechnology (WELBIO), Wallonia, Belgium
Meyer, Christelle ;  Université de Liège - ULiège > Unités de recherche interfacultaires > GIGA-CRC In vivo Imaging (Centre de Recherche du Cyclotron) ; Walloon Excellence in Life Sciences and Biotechnology (WELBIO), Wallonia, Belgium
Degueldre, Christian ;  Université de Liège - ULiège > Unités de recherche interfacultaires > GIGA-CRC In vivo Imaging (Centre de Recherche du Cyclotron)
Berthomier, Christian;  Physip, Paris, France
Luxen, André ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging
Salmon, Eric  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de neurologie ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging
Collette, Fabienne  ;  Université de Liège - ULiège > Département de Psychologie ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging
Dijk, D-J;  Sleep Research Centre, University of Surrey, Guildford, UK ; UK Dementia Research Institute, University of Surrey, Guildford, UK
Schmidt, Christina  ;  Université de Liège - ULiège > Département de Psychologie > Neuropsychologie de l'adulte ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Phillips, Christophe  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Neuroimaging, data acquisition and processing ; ULiège - University of Liège [BE] > GIGA-In Silico Medicine
Maquet, Pierre  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de neurologie ; Walloon Excellence in Life Sciences and Biotechnology (WELBIO), Wallonia, Belgium
Sherif, Siya ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Vandewalle, Gilles  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
More authors (9 more) Less
Language :
English
Title :
In vivo marker of brainstem myelin is associated to quantitative sleep parameters in healthy young men.
Publication date :
27 November 2023
Journal title :
Scientific Reports
eISSN :
2045-2322
Publisher :
Nature Research, England
Volume :
13
Issue :
1
Pages :
20873
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
UK DRI - UK Dementia Research Institute [GB]
FWB - Fédération Wallonie-Bruxelles [BE]
WELBIO - Walloon Excellence in Life Sciences and Biotechnology [BE]
FRA - Fondation pour la Recherche sur la Maladie d'Alzheimer [FR]
ULiège - Université de Liège [BE]
Fondation Pierre et Simone Clerdent [BE]
ERDF - European Regional Development Fund [BE]
Fonds Léon Fredericq [BE]
Funding text :
PT, MD, MVE, EK, FC, CS, CP and GV are/were supported by the Fonds de la Recherche Scientifique—FNRS-Belgium. The study was supported by the Wallonia-Brussels Federation (Actions de Recherche Concertées—ARC—09/14-03), WELBIO/Walloon Excellence in Life Sciences and Biotechnology Grant (WELBIOCR-2010-06E), FNRS-Belgium (FRS-FNRS, F.4513.17 and T.0242.19 and 3.4516.11), Fondation Recherche Alzheimer (SAO-FRA 2019/0025), University of Liège (ULiège), Fondation Simone et Pierre Clerdent, European Regional Development Fund (Radiomed project), Fonds Léon Fredericq. D.J.D. is supported by the UK Dementia Research Institute (DRI). We acknowledge Christian Lambert for providing the scripts to perform the brainstem segmentation.
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