Article (Scientific journals)
Impact of repeated short light exposures on sustained pupil responses in an fMRI environment.
Beckers, Elise; Campbell, Islay; Sharifpour, Roya et al.
2023In Journal of Sleep Research, p. 14085
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Keywords :
functional magnetic resonance imaging; melanopic equivalent daylight illuminance; melanopsin; non-image-forming effect of light; pupil light reflex
Abstract :
[en] Light triggers numerous non-image-forming, or non-visual, biological effects. The brain correlates of these non-image-forming effects have been investigated, notably using magnetic resonance imaging and short light exposures varying in irradiance and spectral quality. However, it is not clear whether non-image-forming responses estimation may be biased by having light in sequential blocks, for example, through a potential carryover effect of one light onto the next. We reasoned that pupil light reflex was an easy readout of one of the non-image-forming effects of light that could be used to address this issue. We characterised the sustained pupil light reflex in 13-16 healthy young individuals under short light exposures during three distinct cognitive processes (executive, emotional and attentional). Light conditions pseudo-randomly alternated between monochromatic orange light (0.16 melanopic equivalent daylight illuminance lux) and polychromatic blue-enriched white light of three different levels (37, 92, 190 melanopic equivalent daylight illuminance lux). As expected, higher melanopic irradiance was associated with larger sustained pupil light reflex in each cognitive domain. This result was stable over the light sequence under higher melanopic irradiance levels compared with lower ones. Exploratory frequency-domain analyses further revealed that sustained pupil light reflex was more variable under lower melanopic irradiance levels. Importantly, sustained pupil light reflex varied across tasks independently of the light condition, pointing to a potential impact of light history and/or cognitive context on sustained pupil light reflex. Together, our results emphasise that the distinct contribution and adaptation of the different retinal photoreceptors influence the non-image-forming effects of light and therefore potentially their brain correlates.
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Beckers, Elise  ;  Université de Liège - ULiège > GIGA ; Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, the Netherlands
Campbell, Islay  ;  Université de Liège - ULiège > GIGA
Sharifpour, Roya  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques
Paparella, Ilenia  ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Berger, Alexandre ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology ; Institute of Neuroscience (IoNS), Université Catholique de Louvain (UCLouvain), Woluwe-Saint-Lambert, Belgium ; Synergia Medical SA, Mont-Saint-Guibert, Belgium
Balda Aizpurua, Fermin  ;  Université de Liège - ULiège > GIGA
Koshmanova, Ekaterina ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques
Mortazavi, Nasrin ;  Université de Liège - ULiège > GIGA
Talwar, Puneet ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques
Sherif, Siya ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Sleep and chronobiology
Jacobs, Heidi I L;  Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, the Netherlands ; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Vandewalle, Gilles  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques
Language :
English
Title :
Impact of repeated short light exposures on sustained pupil responses in an fMRI environment.
Publication date :
30 October 2023
Journal title :
Journal of Sleep Research
ISSN :
0962-1105
eISSN :
1365-2869
Publisher :
Wiley, Oxford, Gb
Pages :
e14085
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 02 December 2023

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