Article (Scientific journals)
Virus-Specific T-Cell Therapy for Viral Infections of the Central Nervous System: A Review.
Lambert, Nicolas; El Moussaoui, Majdouline; Baron, Frédéric et al.
2023In Viruses, 15 (7), p. 1510
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Keywords :
T-cell transfer; adenovirus; cellular therapy; central nervous system; cytomegalovirus; encephalitis; immune therapy; multiple sclerosis; progressive multifocal leukoencephalopathy; viral infections; virus-specific T-cells; Antiviral Agents; Humans; Central Nervous System; Antiviral Agents/therapeutic use; Cell- and Tissue-Based Therapy; Leukoencephalopathy, Progressive Multifocal; Cytomegalovirus Infections; Opportunistic Infections; Central Nervous System Diseases/therapy; Central Nervous System Diseases; Infectious Diseases; Virology
Abstract :
[en] Opportunistic viral infections of the central nervous system represent a significant cause of morbidity and mortality among an increasing number of immunocompromised patients. Since antiviral treatments are usually poorly effective, the prognosis generally relies on the ability to achieve timely immune reconstitution. Hence, strategies aimed at reinvigorating antiviral immune activity have recently emerged. Among these, virus-specific T-cells are increasingly perceived as a principled and valuable tool to treat opportunistic viral infections. Here we briefly discuss how to develop and select virus-specific T-cells, then review their main indications in central nervous system infections, including progressive multifocal leukoencephalopathy, CMV infection, and adenovirus infection. We also discuss their potential interest in the treatment of progressive multiple sclerosis, or EBV-associated central nervous system inflammatory disease. We finish with the key future milestones of this promising treatment strategy.
Disciplines :
Neurology
Author, co-author :
Lambert, Nicolas ;  Université de Liège - ULiège > Département de géoressources, géotechnologies et matériaux de constructions > Géomécanique et géologie de l'ingénieur
El Moussaoui, Majdouline  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des maladies infectieuses - médecine interne
Baron, Frédéric  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique
Maquet, Pierre  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de neurologie
Darcis, Gilles  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des maladies infectieuses - médecine interne
Language :
English
Title :
Virus-Specific T-Cell Therapy for Viral Infections of the Central Nervous System: A Review.
Publication date :
06 July 2023
Journal title :
Viruses
eISSN :
1999-4915
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Switzerland
Volume :
15
Issue :
7
Pages :
1510
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Fondation Léon Fredericq [BE]
Funding text :
The APC was funded by Fondation Léon Fredericq (FHULF/MEL/2023-2024).
Available on ORBi :
since 20 November 2023

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