Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a refined classification from the European society for blood and marrow transplantation (EBMT).
Mohty, Mohamad; Malard, Florent; Alaskar, Ahmed Set al.
2023 • In Bone Marrow Transplantation, 58 (7), p. 749 - 754
[en] Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life-threatening complication that can develop after hematopoietic cell transplantation (HCT). A new definition for diagnosis, and a severity grading system for SOS/VOD in adult patients, was reported a few years ago on behalf of the European Society for Blood and Marrow Transplantation (EBMT). The aim of this work is to update knowledge regarding diagnosis and severity assessment of SOS/VOD in adult patients, and also its pathophysiology and treatment. In particular, we now propose to refine the previous classification and distinguish probable, clinical and proven SOS/VOD at diagnosis. We also provide an accurate definition of multiorgan dysfunction (MOD) for SOS/VOD severity grading based on Sequential Organ Failure Assessment (SOFA) score.
Disciplines :
Hematology
Author, co-author :
Mohty, Mohamad ; Hematology Department, Hôpital Saint-Antoine, and Université Pierre & Marie Curie, Paris, France. mohamad.mohty@inserm.fr
Malard, Florent ; Hematology Department, Hôpital Saint-Antoine, and Université Pierre & Marie Curie, Paris, France
Alaskar, Ahmed S ; King Abdullah International Medical Research Center/King Saud Bin Abdulaziz University for Health Sciences, Dept. of Oncology, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia
Aljurf, Mahmoud ; King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
Bader, Peter ; Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University, Frankfurt/Main, Germany
Baron, Frédéric ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique
Bazarbachi, Ali ; Department of Internal Medicine, American University of Beirut, Beirut, Lebanon
Blaise, Didier ; Aix-Marseille Univ, MSC Lab, Institut Paoli-Calmettes, Department of Hematology, Marseille, France
Brissot, Eolia; Hematology Department, Hôpital Saint-Antoine, and Université Pierre & Marie Curie, Paris, France
Ciceri, Fabio ; San Raffaele Scientific Institute, Hematology and Bone marrow Transplantation Unit, Milan, Italy
Corbacioglu, Selim; Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, University of Regensburg, Regensburg, Germany
Dalle, Jean-Hugues ; Department of Hematology and Immunology, Hospital Robert Debre, Paris 7-Paris Diderot University, Paris, France
Dignan, Fiona; Department of Clinical Haematology, Manchester University NHS Foundation Trust, Manchester, UK
Huynh, Anne; Hematology Department, Institut Universitaire du Cancer Toulouse - Oncopole, Toulouse, France
Kenyon, Michelle ; Department of Haematology, King's College Hospital, London, UK
Nagler, Arnon; Hematology and Bone Marrow Transplantation, Chaim Sheba Medical center, Tel-Hashomer, Israel
Pagliuca, Antonio; Department of Haematology, King's College Hospital, London, UK
Perić, Zinaida; Department of Hematology, University Hospital Centre Zagreb and School of Medicine, University of Zagreb, Zagreb, Croatia
Richardson, Paul G ; Division of Hematology, Mayo Clinic, Rochester, MN, USA
Ruggeri, Annalisa ; San Raffaele Scientific Institute, Hematology and Bone marrow Transplantation Unit, Milan, Italy
Ruutu, Tapani; Clinical Research Institute, Helsinki University Hospital, Helsinki, Finland
Yakoub-Agha, Ibrahim ; CHU de Lille, Univ Lille, INSERM U1286, Infinite, 59000, Lille, France
Duarte, Rafael F; Department of Hematology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain
Carreras, Enric; Josep Carreras Foundation & Leukemia Research Institute, (Hospital Clínic/Barcelona University Campus), Barcelona, Spain
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