[en] Metabolic fatty liver disease caused by high-starch diet restricted the intensive and sustainable development of carnivorous fish such as largemouth bass. In this study, the combination liver proteomic and lipidomic approach was employed to investigate the key signaling pathways and identify the critical biomarkers of fatty liver in largemouth bass. Joint analysis of the correlated differential proteins and lipids revealed nine common metabolic pathways; it was determined that FABP1 were significantly up-regulated in terms of transporting more triglycerides into the liver, while ABCA1 and VDAC1 proteins were significantly down-regulated in terms of preventing the transport of lipids and cholesterol out of the liver, leading to triglyceride accumulation in hepatocyte, eventually resulting in metabolic fatty liver disease. The results indicate that FABP1, ABCA1 and VDAC1 could be potential biomarkers for treating metabolic fatty liver disease of largemouth bass.
Disciplines :
Entomology & pest control
Author, co-author :
Xue, Moyong ; Université de Liège - ULiège > TERRA Research Centre ; Feed Research Institute, Chinese Academy of Agricultural Science, Beijing 100081, China ; Institute of Animal Science, Chinese Academy of Agriculture Sciences, Beijing 100193, China
Yao, Ting; Beijing Institute of Feed Control, Beijing 110108, China
Xue, Min ; Feed Research Institute, Chinese Academy of Agricultural Science, Beijing 100081, China
Francis, Frédéric ; Université de Liège - ULiège > TERRA Research Centre > Gestion durable des bio-agresseurs
Qin, Yuchang; Institute of Animal Science, Chinese Academy of Agriculture Sciences, Beijing 100193, China
Jia, Ming; Feed Research Institute, Chinese Academy of Agricultural Science, Beijing 100081, China
Li, Junguo; Feed Research Institute, Chinese Academy of Agricultural Science, Beijing 100081, China
Gu, Xu; Feed Research Institute, Chinese Academy of Agricultural Science, Beijing 100081, China
Language :
English
Title :
Mechanism Analysis of Metabolic Fatty Liver on Largemouth Bass (Micropterus salmoides) Based on Integrated Lipidomics and Proteomics.
This study was supported by the National Key Research and Development Program of China (2018YFD0900400 and 2019YFD0900200); The Agricultural Science and Technology Innovation Program of CAAS, China (CAAS-ASTIP-2017-FRI-08).
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