[en] Short-chain fatty acids (SCFAs) play an important role in the host system. Among SCFAs, butyrate has received particular attention for its large effect on host immunity, particularly in supplying energy to enterocytes and producing immune cells. Butyrate enters the cells through the Solute Carrier Family 5 Member 8 (SLC5A8) transporters, then works as a histone deacetylase inhibitor (HDAC) that inhibits the activation of Nuclear factor-κB (NF-κB), which down-regulates the expression of IL-1β, IL-6, TNF-α. Meanwhile, butyrate acts as a ligand to activate G protein-coupled receptors GPR41, GPR43, and GPR109, promoting the expression of anti-inflammatory factors. Besides, it inhibits the proinflammatory factors. Further, it can also suppress the expression of chemokines and reduce inflammation to maintain host homeostasis. This paper reviews the research progress highlighting the potential function of butyrate as a factor impacting intestinal health, obesity and brain disorders.
Disciplines :
Animal production & animal husbandry
Author, co-author :
Dang, Guoqi ; Université de Liège - ULiège > TERRA Research Centre ; State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, China. zhanghongfu@caas.cn
Wu, Weida; Institute of Quality Standard & Testing Technology for Agro-Products, Key Laboratory of Agro-product Quality and Safety, Chinese Academy of Agricultural Sciences, Beijing 100081, PR China
Zhang, Hongfu; State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, China. zhanghongfu@caas.cn
Everaert, Nadia ; Université de Liège - ULiège > TERRA Research Centre > Animal Sciences (AS)
Language :
English
Title :
A new paradigm for a new simple chemical: butyrate & immune regulation.
A. Takakuwa K. Nakamura M. Kikuchi R. Sugimoto S. Ohira Y. Yokoi T. Ayabe Butyric Acid and Leucine Induce alpha-Defensin Secretion from Small Intestinal Paneth Cells Nutrients 2019 11 11
Y. Du X. Li C. Su M. Xi X. Zhang Z. Jiang L. Wang B. Hong Butyrate protects against high-fat diet-induced atherosclerosis via up-regulating ABCA1 expression in apolipoprotein E-deficiency mice Br. J. Pharmacol. 2020 177 1754 1772
Y. Fan O. Pedersen Gut microbiota in human metabolic health and disease Nat. Rev. Microbiol. 2021 19 55 71
A. Bedford J. Gong Implications of butyrate and its derivatives for gut health and animal production Anim. Nutr. 2018 4 151 159
P. A. Gill M. C. van Zelm J. G. Muir P. R. Gibson Review article: short chain fatty acids as potential therapeutic agents in human gastrointestinal and inflammatory disorders Aliment. Pharmacol. Ther. 2018 48 15 34
B. K. E. Knudsen H. N. Laerke M. S. Hedemann T. S. Nielsen A. K. Ingerslev D. S. Gundelund Nielsen P. K. Theil S. Purup S. Hald A. G. Schioldan M. L. Marco S. Gregersen K. Hermansen Impact of Diet-Modulated Butyrate Production on Intestinal Barrier Function and Inflammation Nutrients 2018 10 10
N. Singh A. Gurav S. Sivaprakasam E. Brady R. Padia H. Shi M. Thangaraju P. D. Prasad S. Manicassamy D. H. Munn J. R. Lee S. Offermanns V. Ganapathy Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis Immunity 2014 40 128 139
S. Sivaprakasam A. Gurav A. V. Paschall G. L. Coe K. Chaudhary Y. Cai R. Kolhe P. Martin D. Browning L. Huang H. Shi H. Sifuentes M. Vijay-Kumar S. A. Thompson D. H. Munn A. Mellor T. L. McGaha P. Shiao C. W. Cutler K. Liu V. Ganapathy H. Li N. Singh An essential role of Ffar2 (Gpr43) in dietary fibre-mediated promotion of healthy composition of gut microbiota and suppression of intestinal carcinogenesis Oncogenesis 2016 5 e238
H. Shimizu Y. Masujima C. Ushiroda R. Mizushima S. Taira R. Ohue-Kitano I. Kimura 4 Sci. Rep. 2019 9 16574
W. Feng H. Ao C. Peng Gut Microbiota, Short-Chain Fatty Acids, and Herbal Medicines Front. Pharmacol. 2018 9 1354
H. Liu J. Wang T. He S. Becker G. Zhang D. Li X. Ma Butyrate: A Double-Edged Sword for Health? Adv. Nutr. 2018 9 21 29
J. Perez-Escuredo V. F. Van Hee M. Sboarina J. Falces V. L. Payen L. Pellerin P. Sonveaux Monocarboxylate transporters in the brain and in cancer Biochim. Biophys. Acta 2016 1863 2481 2497
M. A. Cuff D. W. Lambert S. P. Shirazi-Beechey Substrate-induced regulation of the human colonic monocarboxylate transporter, MCT1 J. Physiol. 2002 539 361 371
S. Saksena S. Theegala N. Bansal R. K. Gill S. Tyagi W. A. Alrefai K. Ramaswamy P. K. Dudeja Mechanisms underlying modulation of monocarboxylate transporter 1 (MCT1) by somatostatin in human intestinal epithelial cells Am. J. Physiol.: Gastrointest. Liver Physiol. 2009 297 G878 G885
N. Gupta P. M. Martin P. D. Prasad V. Ganapathy SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter Life Sci. 2006 78 2419 2425
L. Rohrbeck M. Adori S. Wang C. He C. A. Tibbitt M. Chernyshev M. Sirel U. Ribacke B. Murrell Y. M. Bohlooly M. C. Karlsson G. B. K. Hedestam J. M. Coquet GPR43 regulates marginal zone B-cell responses to foreign and endogenous antigens Immunol. Cell Biol. 2021 99 234 243
B. Zhou Y. Yuan S. Zhang C. Guo X. Li G. Li W. Xiong Z. Zeng Intestinal Flora and Disease Mutually Shape the Regional Immune System in the Intestinal Tract Front. Immunol. 2020 11 575
K. M. Maslowski A. T. Vieira A. Ng J. Kranich F. Sierro D. Yu H. C. Schilter M. S. Rolph F. Mackay D. Artis R. J. Xavier M. M. Teixeira C. R. Mackay Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43 Nature 2009 461 1282 1286
Y. H. Hong Y. Nishimura D. Hishikawa H. Tsuzuki H. Miyahara C. Gotoh K. C. Choi D. D. Feng C. Chen H. G. Lee K. Katoh S. G. Roh S. Sasaki Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43 Endocrinology 2005 146 5092 5099
M. Li B. van Esch P. A. J. Henricks G. Folkerts J. Garssen The Anti-inflammatory Effects of Short Chain Fatty Acids on Lipopolysaccharide-or Tumor Necrosis Factor alpha-Stimulated Endothelial Cells via Activation of GPR41/43 and Inhibition of HDACs Front. Pharmacol. 2018 9 533
A. Koh F. De Vadder P. Kovatcheva-Datchary F. Bäckhed From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites Cell 2016 165 1332 1345
E. Le Poul C. Loison S. Struyf J. Y. Springael V. Lannoy M. E. Decobecq S. Brezillon V. Dupriez G. Vassart J. Van Damme M. Parmentier M. Detheux Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation J. Biol. Chem. 2003 278 25481 25489
M. H. Kim S. G. Kang J. H. Park M. Yanagisawa C. H. Kim Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice Gastroenterology 2013 145 396 406
K. Zhan X. Gong Y. Chen M. Jiang T. Yang G. Zhao Short-Chain Fatty Acids Regulate the Immune Responses via G Protein-Coupled Receptor 41 in Bovine Rumen Epithelial Cells Front. Immunol. 2019 10 2042
Y. D. Bhutia J. Ogura S. Sivaprakasam V. Ganapathy Gut Microbiome and Colon Cancer: Role of Bacterial Metabolites and Their Molecular Targets in the Host Curr. Colorectal. Cancer Rep. 2017 13 111 118
S. K. Mazmanian J. L. Round D. L. Kasper A microbial symbiosis factor prevents intestinal inflammatory disease Nature 2008 453 620 625
P. Diefenhardt A. Nosko M. A. Kluger J. V. Richter C. Wegscheid Y. Kobayashi G. Tiegs S. Huber R. A. Flavell R. A. K. Stahl O. M. Steinmetz Il-10 receptor signaling empowers regulatory T cells to control Th17 responses and protect from GN J. Am. Soc. Nephrol. 2018 29 1825 1837
E. Larsson V. Tremaroli Y. S. Lee O. Koren I. Nookaew A. Fricker J. Nielsen R. E. Ley F. Backhed Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through MyD88 Gut 2012 61 1124 1131
V. Khatri R. Kalyanasundaram Therapeutic implications of inflammasome in inflammatory bowel disease FASEB J. 2021 35 e21439
R. L. Sabado S. Balan N. Bhardwaj Dendritic cell-based immunotherapy Cell Res. 2017 27 74 95
L. Liu L. Li J. Min J. Wang H. Wu Y. Zeng S. Chen Z. Chu Butyrate interferes with the differentiation and function of human monocyte-derived dendritic cells Cell. Immunol. 2012 277 66 73
C. Nastasi S. Fredholm A. Willerslev-Olsen M. Hansen C. M. Bonefeld C. Geisler M. H. Andersen N. Ødum A. Woetmann Butyrate and propionate inhibit antigen-specific CD8+ T cell activation by suppressing IL-12 production by antigen-presenting cells Sci. Rep. 2017 7 14516
H. Dai G. Wei Y. Wang N. Ma G. Chang X. Shen Guangjun Chang and Xiangzhen Shen, Sodium butyrate promotes lipopolysaccharide-induced innate immune responses by enhancing mitogen-activated protein kinase activation and histone acetylation in bovine mammary epithelial cells J. Dairy Sci. 2020 11636 11652 10.3168/jds.2020-18198
Z. Zhao B. Ciric S. Yu G. X. Zhang A. Rostami Targeting ganglioside epitope 3G11 on the surface of CD4+ T cells suppresses EAE by altering the Treg/Th17 cell balance Int. Immunol. 2010 22 817 826
M. Li B. C. A. M. van G. T. M. Wagenaar J. Garssen G. Folkerts P. A. J. Henricks Pro-and anti-inflammatory effects of short chain fatty acids on immune and endothelial cells Eur. J. Pharmacol. 2018 831 52 59
A. C. Roy G. Chang N. Ma Y. Wang S. Roy J. Liu Z.-U. Aabdin X. Shen Sodium butyrate suppresses NOD1-mediated inflammatory molecules expressed in bovine hepatocytes during iE-DAP and LPS treatment J. Cell Physiol. 2019 234 19602 19620
A. L. Millard P. M. Mertes D. Ittelet F. Villard P. Jeannesson J. Bernard U. Médian Butyrate affects differentiation, maturation and function of human monocyte-derived dendritic cells and macrophages Clin. Exp. Immunol. 2002 130 245 255
A. M. Dudek S. Martin A. D. Garg P. Agostinis Immature, Semi-Mature, and Fully Mature Dendritic Cells: Toward a DC-Cancer Cells Interface That Augments Anticancer Immunity Front. Immunol. 2013 4 438
S. Z. Josefowicz R. E. Niec H. Y. Kim P. Treuting T. Chinen Y. Zheng D. T. Umetsu A. Y. Rudensky Extrathymically generated regulatory T cells control mucosal TH2 inflammation Nature 2012 482 395 399
N. Arpaia C. Campbell X. Fan S. Dikiy J. van der Veeken P. deRoos H. Liu J. R. Cross K. Pfeffer P. J. Coffer A. Y. Rudensky Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation Nature 2013 504 451 455
A. Haghikia S. Jorg A. Duscha J. Berg A. Manzel A. Waschbisch A. Hammer D. H. Lee C. May N. Wilck A. Balogh A. I. Ostermann N. H. Schebb D. A. Akkad D. A. Grohme M. Kleinewietfeld S. Kempa J. Thone S. Demir D. N. Muller R. Gold R. A. Linker Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine Immunity 2015 43 817 829
W. Wu M. Sun F. Chen S. Yao Z. Liu Y. Cong Microbiota Metabolite Short Chain Fatty Acid Acetate Promotes Intestinal IgA Response to Microbiota which is Mediated by GPR43 Gastroenterology 2017 10 946 956
A. Wilcock R. Bahri S. Bulfone-Paus P. D. Arkwright Mast cell disorders: From infancy to maturity Allergy 2019 74 53 63
M. Albert-Bayo I. Paracuellos A. M. Gonzalez-Castro A. Rodriguez-Urrutia M. J. Rodriguez-Lagunas C. Alonso-Cotoner J. Santos M. Vicario Intestinal Mucosal Mast Cells: Key Modulators of Barrier Function and Homeostasis Cells 2019 8 135
C. Diakos E. E. Prieschl M. D. Saemann G. A. Bohmig R. Csonga Y. Sobanov T. Baumruker G. J. Zlabinger n-Butyrate inhibits Jun NH(2)-terminal kinase activation and cytokine transcription in mast cells Biochem. Biophys. Res. Commun. 2006 349 863 868
J. Ji D. Shu M. Zheng J. Wang C. Luo Y. Wang F. Guo X. Zou X. Lv Y. Li T. Liu H. Qu Microbial metabolite butyrate facilitates M2 macrophage polarization and function Sci. Rep. 2016 6 24838
C. C. Wang H. Wu F. H. Lin R. Gong F. Xie Y. Peng J. Feng C. H. Hu Sodium butyrate enhances intestinal integrity, inhibits mast cell activation, inflammatory mediator production and JNK signaling pathway in weaned pigs Innate Immun. 2018 24 40 46
J. Folkerts F. Redegeld G. Folkerts B. Blokhuis M. P. M. van den Berg M. J. W. de Bruijn W. F. J. van IJcken T. Junt S. Y. Tam S. J. Galli R. W. Hendriks R. Stadhouders M. Maurer Butyrate inhibits human mast cell activation via epigenetic regulation of FcepsilonRI-mediated signaling Allergy 2020 75 1966 1978
H. Y. Liao L. Tao J. Zhao J. Qin G. C. Zeng S. W. Cai Y. Li J. Zhang H. G. Chen Clostridium butyricum in combination with specific immunotherapy converts antigen-specific B cells to regulatory B cells in asthmatic patients Sci. Rep. 2016 6 20481
Y. Shi L. Z. Xu K. Peng W. Wu R. Wu Z. Q. Liu G. Yang X. R. Geng J. Liu Z. G. Liu Z. Liu P. C. Yang Specific immunotherapy in combination with Clostridium butyricum inhibits allergic inflammation in the mouse intestine Sci. Rep. 2015 5 17651
E. C. Rosser C. J. M. Piper D. E. Matei et al., Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells Cell Metab. 2020 31 837 851
V. J. Sindhava S. Bondada Multiple regulatory mechanisms control B-1 B cell activation Front. Immunol. 2012 3 372
S. Mrozinska P. Kapusta T. Gosiewski A. Sroka-Oleksiak A. H. Ludwig-Slomczynska B. Matejko B. Kiec-Wilk M. Bulanda M. T. Malecki P. P. Wolkow T. Klupa The Gut Microbiota Profile According to Glycemic Control in Type 1 Diabetes Patients Treated with Personal Insulin Pumps Microorganisms 2021 9 1
P. Guilloteau R. Zabielski J. C. David J. W. Blum J. A. Morisset M. Biernat J. Wolinski D. Laubitz Y. Hamon Sodium-butyrate as a growth promoter in milk replacer formula for young calves J. Dairy Sci. 2009 92 1038 1049
J. Chen L. Vitetta Inflammation-Modulating Effect of Butyrate in the Prevention of Colon Cancer by Dietary Fiber Clin. Colorectal Cancer 2018 17 e541 e544
V. Ganapathy M. Thangaraju P. D. Prasad P. M. Martin N. Singh Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host Curr. Opin. Pharmacol. 2013 13 869 874
J. Zhang Q. Zhong Histone deacetylase inhibitors and cell death Cell. Mol. Life Sci. 2014 71 3885 3901
J. Park M. Kim S. G. Kang A. H. Jannasch B. Cooper J. Patterson C. H. Kim Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6 K pathway Mucosal Immunol. 2015 8 80 93
C. Martin-Gallausiaux F. Beguet-Crespel L. Marinelli A. Jamet F. Ledue H. M. Blottiere N. Lapaque Butyrate produced by gut commensal bacteria activates TGF-beta1 expression through the transcription factor SP1 in human intestinal epithelial cells Sci. Rep. 2018 8 9742
S. Khan G. B. Jena Protective role of sodium butyrate, a HDAC inhibitor on beta-cell proliferation, function and glucose homeostasis through modulation of p38/ERK MAPK and apoptotic pathways: study in juvenile diabetic rat Chem.-Biol. Interact. 2014 213 1 12
T. H. Chen W. M. Chen K. H. Hsu C. D. Kuo S. C. Hung Sodium butyrate activates ERK to regulate differentiation of mesenchymal stem cells Biochem. Biophys. Res. Commun. 2007 355 913 918
F. Zou Y. Qiu Y. Huang H. Zou X. Cheng Q. Niu A. Luo J. Sun Effects of short-chain fatty acids in inhibiting HDAC and activating p38 MAPK are critical for promoting B10 cell generation and function Cell Death Dis. 2021 12 582
P. V. Chang L. Hao S. Offermanns R. Medzhitov The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition Proc. Natl. Acad. Sci. U. S. A. 2014 111 2247 2252
X. Wang G. He Y. Peng W. Zhong Y. Wang B. Zhang Sodium butyrate alleviates adipocyte inflammation by inhibiting NLRP3 pathway Sci. Rep. 2015 5 12676
Y. Chen A. L. Pitzer X. Li P. L. Li L. Wang Y. Zhang Instigation of endothelial Nlrp3 inflammasome by adipokine visfatin promotes inter-endothelial junction disruption: role of HMGB1 J. Cell. Mol. Med. 2015 19 2715 2727
A. Sandstrom P. S. Mitchell L. Goers E. W. Mu C. F. Lesser R. E. Vance Functional degradation A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes Science 2019 364 6435
X. Yuan L. Wang O. M. Bhat H. Lohner P. L. Li Differential effects of short chain fatty acids on endothelial Nlrp3 inflammasome activation and neointima formation: Antioxidant action of butyrate Redox Biol. 2018 16 21 31
L. Maroni L. Agostinelli S. Saccomanno C. Pinto D. M. Giordano C. Rychlicki S. De Minicis L. Trozzi J. M. Banales E. Melum T. H. Karlsen A. Benedetti G. S. Baroni M. Marzioni Nlrp3 Activation Induces Il-18 Synthesis and Affects the Epithelial Barrier Function in Reactive Cholangiocytes Am. J. Pathol. 2017 187 366 376
Y. Feng Y. Wang P. Wang Y. Huang F. Wang Short-Chain Fatty Acids Manifest Stimulative and Protective Effects on Intestinal Barrier Function Through the Inhibition of NLRP3 Inflammasome and Autophagy Cell. Physiol. Biochem. 2018 49 190 205
H. W. Chiu C. H. Chen J. N. Chang C. H. Chen Y. H. Hsu Far-infrared promotes burn wound healing by suppressing NLRP3 inflammasome caused by enhanced autophagy J. Mol. Med. 2016 94 809 819
L. Macia J. Tan A. T. Vieira K. Leach D. Stanley S. Luong M. Maruya C. I. McKenzie A. Hijikata C. Wong L. Binge A. N. Thorburn N. Chevalier C. Ang E. Marino R. Robert S. Offermanns M. M. Teixeira R. J. Moore R. A. Flavell S. Fagarasan C. R. Mackay Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome Nat. Commun. 2015 6 6734
N. Roshanravan N. M. Alamdari M. A. Jafarabadi A. Mohammadi B. R. Shabestari N. Nasirzadeh S. Asghari B. Mansoori M. Akbarzadeh A. Ghavami S. Ghaffari A. Ostadrahimi Effects of oral butyrate and inulin supplementation on inflammation-induced pyroptosis pathway in type 2 diabetes: A randomized, double-blind, placebo-controlled trial Cytokine 2020 131 155101
W. Yip M. R. Hughes Y. Li A. Cait M. Hirst W. W. Mohn K. M. McNagny Butyrate Shapes Immune Cell Fate and Function in Allergic Asthma Front. Immunol. 2021 12 628453
M. Kinoshita Y. Suzuki Y. Saito Butyrate reduces colonic paracellular permeability by enhancing PPARgamma activation Biochem. Biophys. Res. Commun. 2002 293 827 831
M. X. Byndloss E. E. Olsan F. Rivera-Chavez C. R. Tiffany S. A. Cevallos K. L. Lokken T. P. Torres A. J. Byndloss F. Faber Y. Gao Y. Litvak C. A. Lopez G. Xu E. Napoli C. Giulivi R. M. Tsolis A. Revzin C. B. Lebrilla A. J. Baumler Microbiota-activated PPAR-gamma signaling inhibits dysbiotic Enterobacteriaceae expansion Science 2017 357 570 575
L. Wu C. Guo J. Wu Therapeutic potential of PPARgamma natural agonists in liver diseases J. Cell. Mol. Med. 2020 24 2736 2748
P. P. Tak G. S. Firestein NF-kappaB: a key role in inflammatory diseases J. Clin. Invest. 2001 107 7 11
J. Jia L. Nie Y. Liu Butyrate alleviates inflammatory response and NF-kappaB activation in human degenerated intervertebral disc tissues Int. Immunopharmacol. 2020 78 106004
L. Jiang J. Wang Z. Liu A. Jiang S. Li D. Wu Y. Zhang X. Zhu E. Zhou Z. Wei Z. Yang Sodium Butyrate Alleviates Lipopolysaccharide-Induced Inflammatory Responses by Down-Regulation of NF-kappaB, NLRP3 Signaling Pathway, and Activating Histone Acetylation in Bovine Macrophages Front. Vet. Sci. 2020 7 579674
Y. L. Qiao J. M. Qian F. R. Wang Z. Y. Ma Q. W. Wang Butyrate protects liver against ischemia reperfusion injury by inhibiting nuclear factor kappa B activation in Kupffer cells J. Surg. Res. 2014 187 653 659
Y. Yamamoto R. B. Gaynor IkappaB kinases: key regulators of the NF-kappaB pathway Trends Biochem. Sci. 2004 29 72 79
W. Bo J. Zhou K. Wang Sodium butyrate abolishes the degradation of type II collagen in human chondrocytes Biomed. Pharmacother. 2018 102 1099 1104
M. J. Jang U. H. Park J. W. Kim H. Choi S. J. Um E. J. Kim CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPARgamma and inhibit adipogenesis Cell Death Dis. 2017 8 3201
J. M. Monk D. Lepp C. P. Zhang W. Wu L. Zarepoor J. T. Lu K. P. Pauls R. Tsao G. A. Wood L. E. Robinson K. A. Power Diets enriched with cranberry beans alter the microbiota and mitigate colitis severity and associated inflammation J. Nutr. Biochem. 2016 28 129 139
P. Vernia G. Monteleone G. Grandinetti G. Villotti E. Di Giulio G. Frieri A. Marcheggiano F. Pallone R. Caprilli A. Torsoli Combined oral sodium butyrate and mesalazine treatment compared to oral mesalazine alone in ulcerative colitis: randomized, double-blind, placebo-controlled pilot study Dig. Dis. Sci. 2000 45 976 981
C. Hallert I. Björck M. Nyman A. Pousette C. Grännö H. Svensson Increasing fecal butyrate in ulcerative colitis patients by diet: controlled pilot study Inflamm. Bowel Dis. 2003 9 116 121
E. Hijova J. Kuzma L. Strojný A. Bomba I. Bertková A. Chmelárová Z. Hertelyová V. Benetinová J. Štofilová L. Ambro Ability of Lactobacillus plantarum LS/07 to modify intestinal enzymes activity in chronic diseases prevention Acta Biochim. Pol. 2017 64 113 116
T. M. Ferreira A. J. Leonel M. A. Melo R. R. Santos D. C. Cara V. N. Cardoso M. I. Correia J. I. Alvarez-Leite Oral supplementation of butyrate reduces mucositis and intestinal permeability associated with 5-Fluorouracil administration Lipids 2012 47 669 678
M. Zhang Q. Zhou R. G. Dorfman X. Huang T. Fan H. Zhang J. Zhang C. Yu Butyrate inhibits interleukin-17 and generates Tregs to ameliorate colorectal colitis in rats BMC Gastroenterol. 2016 16 84
J. R. Sim S. S. Kang D. Lee C. H. Yun S. H. Han Killed Whole-Cell Oral Cholera Vaccine Induces CCL20 Secretion by Human Intestinal Epithelial Cells in the Presence of the Short-Chain Fatty Acid, Butyrate Front. Immunol. 2018 9 55
T. L. Roy E. M. D. Hase M. V. Hul A. Paquot R. Pelicaen M. Regnier C. Depommier C. Druart A. Everard D. Maiter N. M. Delzenne L. B. Bindels M. de Barsy A. Loumaye M. P. Hermans J. P. Thissen S. Vieira-Silva G. Falony J. Raes G. G. Muccioli P. D. Cani Dysosmobacter welbionis is a newly isolated human commensal bacterium preventing diet-induced obesity and metabolic disorders in mice Gut 2021 0 1 10
J. Chen L. Vitetta The Role of Butyrate in Attenuating Pathobiont-Induced Hyperinflammation Immune Netw. 2020 20 e15
C. Luceri A. P. Femia M. Fazi C. Di Martino F. Zolfanelli P. Dolara F. Tonelli Effect of butyrate enemas on gene expression profiles and endoscopic/histopathological scores of diverted colorectal mucosa: A randomized trial Dig. Liver Dis. 2016 48 27 33
Z. Li L. Li S. Katiraei S. Kooijman E. Zhou C. K. Chung Y. Gao H. J. K. van den O. C. Meijer J. F. P. Berbée M. Heijink M. Giera K. W. van Dijk A. K. Groen P. C. N. Rensen Y. Wang Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit Gut 2018 67 1269 1279
B. Li L. Li M. Li S. M. Lam G. Wang Y. Wu H. Zhang C. Niu X. Zhang X. Liu C. Hambly W. Jin G. Shui J. R. Speakman Microbiota Depletion Impairs Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue Cell Rep. 2019 26 2720 2737
C. L. Dan Wang H. Li M. Tian J. Pan G. Shu Q. Jiang Y. Yin L. Zhang LSD1 mediates microbial metabolite butyrate-induced thermogenesis in brown and white adipose tissue Metabolism 2020 102 1 9
J. Hong Y. Jia S. Pan L. Jia H. Li Z. Han D. Cai R. Zhao Butyrate alleviates high fat diet-induced obesity through activation of adiponectin-mediated pathway and stimulation of mitochondrial function in the skeletal muscle of mice Oncotarget 2016 7 56071 56082
H. W. F. Katrien C. K. Poelaert J. Van Cleemput H. J. Nauwynck Beyond Gut Instinct: Metabolic Short-Chain Fatty Acids Moderate the Pathogenesis of Alphaherpesviruses Front. Microbiol. 2019 10 723
L. Hoyles T. Snelling U. K. Umlai J. K. Nicholson S. R. Carding R. C. Glen S. McArthur Microbiome-host systems interactions: protective effects of propionate upon the blood-brain barrier Microbiome 2018 6 55
P. Strandwitz Neurotransmitter modulation by the gut microbiota Brain Res. 2018 15 128 133
I. Paiva R. Pinho M. A. Pavlou M. Hennion P. Wales A. L. Schuütz A. Rajput E. M. Szego C. Kerimoglu E. Gerhardt A. C. Rego A. Fischer S. Bonn T. F. Outeiro Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage Hum. Mol. Genet. 2017 26 2231 2246
A. Salama W. Ibrahim E. Tousson S. Sakr A. Masoud M. A. Akela E. R. M. A. Abd Epigenetic Study of Parkinson's Disease in Experimental Animal Model Pharmacologia 2015 3 11 20
M. Lorente-Picon A. Laguna New Avenues for Parkinson's Disease Therapeutics: Disease-Modifying Strategies Based on the Gut Microbiota Biomolecules 2021 11 433
M. Agata A controversy on the role of short-chain fatty acids in the pathogenesis of Parkinson's disease Mov. Disord. 2018 33 398 401
J. W. D. Timothy R. Sampson T. Thron S. Janssen G. G. Shastri Z. E. Ilhan C. Challis C. E. Schretter S. Rocha V. Gradinaru M. F. Chesselet A. Keshavarzian K. M. Shannon R. Krajmalnik-Brown P. W. Stafshede R. Knight S. K. Mazmanian Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease Cell 2016 167 1469 1480
J. Sun Z. Ling F. Wang W. Chen H. Li J. Jin H. Zhang M. Pang J. Yu J. Liu Clostridium butyricum pretreatment attenuates cerebral ischemia/reperfusion injury in mice via anti-oxidation and anti-apoptosis Neurosci. Lett. 2016 613 30 35
A. Bertacco C. A. Dehner G. Caturegli F. D'Amico R. Morotti M. I. Rodriguez D. C. Mulligan M. A. Kriegel J. P. Geibel Modulation of Intestinal Microbiome Prevents Intestinal Ischemic Injury Front. Physiol. 2017 8 1064
L. Mohle D. Mattei M. M. Heimesaat S. Bereswill A. Fischer M. Alutis T. French D. Hambardzumyan P. Matzinger I. R. Dunay S. A. Wolf Ly6C(hi) Monocytes Provide a Link between Antibiotic-Induced Changes in Gut Microbiota and Adult Hippocampal Neurogenesis Cell Rep. 2016 15 1945 1956
T. Yonezawa Y. Kobayashi Y. Obara Short-chain fatty acids induce acute phosphorylation of the p38 mitogen-activated protein kinase/heat shock protein 27 pathway via GPR43 in the MCF-7 human breast cancer cell line Cell Signal 2007 19 185 193
